A Review of the Development of Biopolymer Hydrogel-Based Scaffold Materials for Drug Delivery and Tissue Engineering Applications DOI Creative Commons
Madhappan Santhamoorthy, Seong‐Cheol Kim

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 178 - 178

Published: March 1, 2025

Biopolymer hydrogel-based scaffold materials have received a lot of interest in tissue engineering and regenerative medicine because their unique characteristics, which include biocompatibility, biodegradability, the ability to replicate natural extracellular matrix (ECM). These hydrogels are three-dimensional biopolymer networks that highly hydrated provide supportive, wet environment conducive cell growth, migration, differentiation. They especially useful applications involving wound healing, cartilage, bone, soft regeneration. Natural biopolymers such as collagen, chitosan, hyaluronic acid, alginate frequently employed foundation for hydrogel fabrication, providing benefits low toxicity improved adherence. Despite potential, scaffolds various difficulties prevent broad clinical implementation. Key challenge balancing mechanical strength flexibility meet needs tissues, managing degradation rates line up with regeneration, assuring large-scale manufacturing while retaining uniformity quality. Furthermore, fostering appropriate vascularization infiltration larger tissues remains significant optimal integration function. Future developments likely concentrate on addressing these obstacles. Strategies creation hybrid combine synthetic materials, smart stimulus-responsive features, 3D bioprinting technologies accurate production show potential. integrating bioactive compounds growth factors into matrices promote regeneration is critical enhancing therapeutic results.

Language: Английский

A Review of the Development of Biopolymer Hydrogel-Based Scaffold Materials for Drug Delivery and Tissue Engineering Applications DOI Creative Commons
Madhappan Santhamoorthy, Seong‐Cheol Kim

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 178 - 178

Published: March 1, 2025

Biopolymer hydrogel-based scaffold materials have received a lot of interest in tissue engineering and regenerative medicine because their unique characteristics, which include biocompatibility, biodegradability, the ability to replicate natural extracellular matrix (ECM). These hydrogels are three-dimensional biopolymer networks that highly hydrated provide supportive, wet environment conducive cell growth, migration, differentiation. They especially useful applications involving wound healing, cartilage, bone, soft regeneration. Natural biopolymers such as collagen, chitosan, hyaluronic acid, alginate frequently employed foundation for hydrogel fabrication, providing benefits low toxicity improved adherence. Despite potential, scaffolds various difficulties prevent broad clinical implementation. Key challenge balancing mechanical strength flexibility meet needs tissues, managing degradation rates line up with regeneration, assuring large-scale manufacturing while retaining uniformity quality. Furthermore, fostering appropriate vascularization infiltration larger tissues remains significant optimal integration function. Future developments likely concentrate on addressing these obstacles. Strategies creation hybrid combine synthetic materials, smart stimulus-responsive features, 3D bioprinting technologies accurate production show potential. integrating bioactive compounds growth factors into matrices promote regeneration is critical enhancing therapeutic results.

Language: Английский

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