G-protein Coupled Receptors (GPCRs): A Potential Target of Apigenin as a Novel hACE2 Receptor Specific Therapeutic for Impeding Lung Cancer Considering a Group of Missense and Nonsense Mutations in COVID-19 Patients DOI Creative Commons
Rasel Ahmed, Sharmin Akter,

Fnu Nurunnahar

et al.

European Journal of Pharmaceutical Research, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 15

Published: May 13, 2025

This research investigates the role of mutation cascades in enhancing COVID-19-related lung cancer fatalities, specifically through analyzing mutations ACE2 gene associated with SARS-CoV-2 infections. Notably, a natural flavonoid, apigenin, has been identified as promising hACE2-specific therapeutic. The study involved detailed examinations 27 (23 missense and four nonsense) molecular interactions between apigenin hACE2, revealing binding energy -8.1 Kcal/mol. Various dynamics parameters suggested stable interactions, while drug-gene interaction analysis demonstrated that 18 GPCR genes could metabolize effectively blocking hACE2 thereby inhibiting S-protein attachment. findings propose serve targeted therapy for COVID-19-induced cancer.

Language: Английский

G-protein Coupled Receptors (GPCRs): A Potential Target of Apigenin as a Novel hACE2 Receptor Specific Therapeutic for Impeding Lung Cancer Considering a Group of Missense and Nonsense Mutations in COVID-19 Patients DOI Creative Commons
Rasel Ahmed, Sharmin Akter,

Fnu Nurunnahar

et al.

European Journal of Pharmaceutical Research, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 15

Published: May 13, 2025

This research investigates the role of mutation cascades in enhancing COVID-19-related lung cancer fatalities, specifically through analyzing mutations ACE2 gene associated with SARS-CoV-2 infections. Notably, a natural flavonoid, apigenin, has been identified as promising hACE2-specific therapeutic. The study involved detailed examinations 27 (23 missense and four nonsense) molecular interactions between apigenin hACE2, revealing binding energy -8.1 Kcal/mol. Various dynamics parameters suggested stable interactions, while drug-gene interaction analysis demonstrated that 18 GPCR genes could metabolize effectively blocking hACE2 thereby inhibiting S-protein attachment. findings propose serve targeted therapy for COVID-19-induced cancer.

Language: Английский

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