Deep Eutectic Solvents: A Review of Fundamentals and Applications

Chemical Reviews, Journal Year: 2020, Volume and Issue: 121(3), P. 1232 - 1285

Published: Dec. 14, 2020

Deep eutectic solvents (DESs) are an emerging class of mixtures characterized by significant depressions in melting points compared to those the neat constituent components. These materials promising for applications as inexpensive "designer" exhibiting a host tunable physicochemical properties. A detailed review current literature reveals lack predictive understanding microscopic mechanisms that govern structure–property relationships this solvents. Complex hydrogen bonding is postulated root cause their point and properties; understand these bonded networks, it imperative study systems dynamic entities using both simulations experiments. This emphasizes recent research efforts order elucidate next steps needed develop fundamental framework deeper DESs. It covers developments DES research, frames outstanding scientific questions, identifies thrusts aligned with advancement field toward models

Language: Английский

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Phenolic hydrogen bond donors in the formation of non-ionic deep eutectic solvents: the quest for type V DES

Chemical Communications, Journal Year: 2019, Volume and Issue: 55(69), P. 10253 - 10256

Published: Jan. 1, 2019

Mixtures of non-ionic compounds have been reported as DES but most are just ideal mixtures. In the thymol-menthol system, an abnormal strong interaction was identified stemming from acidity difference phenolic and aliphatic hydroxyl groups. This type is found to be key prepare DES, that may classified V.

Language: Английский

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Hydrophobic deep eutectic solvents in microextraction techniques–A review

Microchemical Journal, Journal Year: 2019, Volume and Issue: 152, P. 104384 - 104384

Published: Nov. 1, 2019

Over the past decade, deep eutectic solvents (DES) have been widely studied and applied in sample preparation techniques. Until recently, most of synthesized DES were hydrophilic, which prevented their use extraction aqueous samples. However, after 2015 studies on synthesis application hydrophobic (HDES) has rapidly expanded. Due to unique properties HDES i.e. density, viscosity, acidity or basicity, polarity volatility, good extractabilities for various target analytes, could be altered by careful selection hydrogen bond donor (HBD) acceptor (HBA) components, are promising alternatives traditional organic employed preparation. Moreover, possibility non-toxic ingredients, makes meet all standards green analytical chemistry. Practical applications include conventional liquid-liquid extraction, several types liquid-phase microextraction, as well solid phase extraction. The present review covers a comprehensive summarizing available literature data important physicochemical playing key role methods, limitations challenges this area, perspective future described.

Language: Английский

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Revisiting greenness of ionic liquids and deep eutectic solvents

Green Chemical Engineering, Journal Year: 2021, Volume and Issue: 2(2), P. 174 - 186

Published: Feb. 6, 2021

Green solvents are one of the hot topics green chemistry. Ionic liquids (ILs) and deep eutectic (DESs) deemed as to a certain extent, they have been applied in many areas, such dissolution, separation, catalysis, electrochemistry material synthesis. However, greenness ILs DESs should be revisited because more evidences shown that not always green. In this perspective, besides reported merits, disadvantages problems some DESs, instability, volatility, hygroscopicity, toxicity, flammability, regenerability, cost, energy consumption impurities discussed. Moreover, 13 strategies avoid increase proposed. Comparison is further conducted. This perspective provides new viewpoints on DESs.

Language: Английский

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Physicochemical properties of deep eutectic solvents: A review

Journal of Molecular Liquids, Journal Year: 2022, Volume and Issue: 360, P. 119524 - 119524

Published: June 3, 2022

Language: Английский

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Ionic Liquids Toxicity—Benefits and Threats

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(17), P. 6267 - 6267

Published: Aug. 29, 2020

Ionic liquids (ILs) are solvents with salt structures. Typically, they contain organic cations (ammonium, imidazolium, pyridinium, piperidinium or pyrrolidinium), and halogen, fluorinated anions. While ILs considered to be environmentally-friendly compounds, only a few reasons support this claim. This is because of high thermal stability, negligible pressure at room temperature which makes them non-volatile, therefore preventing the release into atmosphere. The expansion range applications in many chemical industry fields has led growing threat contamination aquatic terrestrial environments by these compounds. As possibility environment s grow systematically, there an increasing urgent obligation determine their toxic antimicrobial influence on environment. Many bioassays were carried out evaluate (eco)toxicity biodegradability ILs. Most have questioned "green" features as turned towards organisms from varied trophic levels. Therefore, need for new biodegradable, less "greener" review presents potential risks linked application These following: cytotoxicity evaluated use human cells, toxicity manifesting aqueous environments. studies proving relation between structures versus special emphasis directions suitable designing safer synthesized renewable sources also presented. representants generation easily biodegradable derivatives amino acids, sugars, choline, bicyclic monoterpene moiety collected. Some benefits using medicine, agriculture, bio-processing

Language: Английский

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The perspectives of natural deep eutectic solvents in agri-food sector

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(15), P. 2564 - 2592

Published: Aug. 13, 2019

The principles of ‘green chemistry’ are gaining importance in agri-food sector due to the need reduce pollution from toxic chemicals, make industrial processes safer and more sustainable, offer ‘clean-labeled products’ required by consumers. application natural deep eutectic solvents (NADES) – product-based green liquids is considered promising alternative conventional organic solvents. This review intended summarize discuss recent advances related physicochemical properties NADES, their applications, compatibility with analytic techniques toxicological profile, pointing out challenges necessary improvements for wider utilization sector. NADES allow extraction wide range food compounds they proven be convenient food-related applications. However, potential scale-up not completely investigated. Examined readily biodegradable, but only preliminary studies on toxicity which include limited number molecules available. Apart fundamental research dealing formation nature interactions structure underpinning liquid phase formation, question purity obtained different synthetic methodologies addressed future. Data synthetized still needed as relevant

Language: Английский

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The Curious Case of Hydrophobic Deep Eutectic Solvents: A Story on the Discovery, Design, and Applications

ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: unknown

Published: June 2, 2020

Hydrophobic deep eutectic solvents (DESs) are a new generation of water immiscible that have been presented in the literature for first time 2015. These used many applications. Here, an overview is given regarding hydrophobic DESs with their physicochemical properties, applications, and challenges limitations field currently experiencing. First, general introduction to explain more about DESs, origin, ones. also, all given. After introduction, properties such as density, viscosity, melting point, degradation temperature, volatilities, solvatochromic discussed. It continued discussion 21 different applications DESs. In general, related liquid–liquid extractions, microextractions, formation two three phase systems, removal components from leaves, gas–liquid hydrogels, membrane formation, centrifugal partition chromatography, ferrofluid, coating, photoluminescence, dye-sensitized solar cells, catalysis investigated. Finally,

Language: Английский

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Hydrophobic deep eutectic solvents: the new generation of green solvents for diversified and colorful applications in green chemistry

Journal of Cleaner Production, Journal Year: 2021, Volume and Issue: 314, P. 127965 - 127965

Published: June 18, 2021

Language: Английский

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Type V deep eutectic solvents: Design and applications

Current Opinion in Green and Sustainable Chemistry, Journal Year: 2022, Volume and Issue: 35, P. 100612 - 100612

Published: March 18, 2022

Type V deep eutectic solvents are a novel class of sustainable solvents. They prepared by physically mixing solid, non-ionic components and characterized strong negative deviations from thermodynamic ideality. This work provides guidelines for the rational design these reviews some their recent applications. Emphasis is given on choice hydrogen bond donors acceptors to achieve necessary liquid phase non-ideality, namely use pairs molecules with high polarity asymmetry, stresses importance assessing solid–liquid diagrams. Polymorphism cocrystal formation also briefly addressed, together predictive methodologies that have been developed estimate properties.

Language: Английский

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