Applications of Carbon Nanotubes in Drug Delivery

Elsevier eBooks, Journal Year: 2018, Volume and Issue: unknown, P. 113 - 135

Published: Oct. 12, 2018

Language: Английский

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Red‐Emissive Carbon Dots for Fluorescent, Photoacoustic, and Thermal Theranostics in Living Mice

Advanced Materials, Journal Year: 2015, Volume and Issue: 27(28), P. 4169 - 4177

Published: June 5, 2015

Novel red-emissive carbon-dots (C-dots) with broad absorption in the region from 400 to 750 nm are prepared polythiophene phenylpropionic acid. Upon near infrared laser irradiation, C-dots show strong photoacoustic response and high photothermal conversion efficiency (η ≈ 38.5%). These unique properties enable act as multifunctional fluorescent, photoacoustic, thermal theranostics for simultaneous diagnosis therapy of cancer. As a service our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising (other than missing files) should addressed Please note: The publisher is responsible content functionality any Any queries content) directed corresponding author article.

Language: Английский

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Sol–gel based materials for biomedical applications

Progress in Materials Science, Journal Year: 2016, Volume and Issue: 77, P. 1 - 79

Published: Jan. 17, 2016

Sol–gel chemistry offers a flexible approach to obtaining diverse range of materials. It allows differing chemistries be achieved as well offering the ability produce wide nano-/micro-structures. The paper commences with generalized description various sol–gel methods available and how these control bulk properties end products. Following this, more detailed biomedical areas where materials have been explored found hold significant potential. One interesting fields that has developed recently relates hybrid utilize achieve unusual composite properties. Another intriguing feature sol–gels is morphologies are achievable at micro- nano-scale. Subsequently pore number different length scales geometries proven fruitful area exploitation, provides excellent bioactivity attracts cellular responses enables entrapment biologically active molecules their controllable release for therapeutic action. approaches fine-tuning surface combination other nanomaterials also enabled targeting specific cell tissue types drug delivery imaging capacity.

Language: Английский

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Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future

Chemical Society Reviews, Journal Year: 2017, Volume and Issue: 46(22), P. 7021 - 7053

Published: Jan. 1, 2017

Chemotherapy is currently one of the most effective ways to treat cancer. However, traditional chemotherapy faces several obstacles clinical trials, such as poor solubility/stability, non-targeting capability and uncontrollable release drugs, greatly limiting their anticancer efficacy causing severe side effects towards normal tissues. Supramolecular integrating non-covalent interactions a highly promising candidate in this regard can be appropriately used for targeted drug delivery. By taking advantage supramolecular chemistry, some limitations impeding applications solved effectively. Therefore, we present here review summarizing progress cancer treatment based on host-guest recognition provide guidance design new targeting combining diagnostic therapeutic functions. Based large number state-of-the-art studies, our will advance basis promote translational applications.

Language: Английский

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Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Chemical Reviews, Journal Year: 2015, Volume and Issue: 115(19), P. 11012 - 11042

Published: Aug. 5, 2015

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMolecular Interactions in Organic Nanoparticles for Phototheranostic ApplicationsKenneth K. Ng†∥ and Gang Zheng*†‡§∥View Author Information† ‡ § †Institute of Biomaterials Biomedical Engineering, ‡Department Medical Biophysics, §Department Pharmaceutical Sciences, Leslie Dan Faculty Pharmacy, University Toronto, Ontario M5S, Canada∥ Princess Margaret Cancer Centre Techna Institute, Health Network, M5G 2C4, Canada*E-mail: [email protected]Cite this: Chem. Rev. 2015, 115, 19, 11012–11042Publication Date (Web):August 5, 2015Publication History Received9 March 2015Published online5 August inissue 14 October 2015https://doi.org/10.1021/acs.chemrev.5b00140Copyright © 2015 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views17220Altmetric-Citations397LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (22 MB) Get e-AlertsSUBJECTS:Conjugated polymers,Dyes pigments,Fluorescence,Molecules,Nanoparticles e-Alerts

Language: Английский

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Nanocatalytic Medicine

Advanced Materials, Journal Year: 2019, Volume and Issue: 31(39)

Published: July 22, 2019

Abstract Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such nanozymes, photocatalysts, electrocatalysts, have been applied vivo to initiate catalytic reactions modulate biological microenvironments for generating therapeutic effects. The rapid growth biomedical applications nanocatalysts has led the concept “nanocatalytic medicine,” which is expected promote further advance a subdiscipline nanomedicine. high efficiency selectivity catalysis that chemists strived achieve past century can be ingeniously translated into efficacy mitigated side effects theranostics using medicine” steer optimized outcomes. Here, rationale behind construction nanocatalytic eludicated based on essential reaction factors (catalysts, energy input, reactant). Recent this burgeoning field then comprehensively presented mechanisms nanosystems conferred theranostic functions discussed detail. It believed an emerging modality will play more important role

Language: Английский

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Two-photon excitation nanoparticles for photodynamic therapy

Chemical Society Reviews, Journal Year: 2016, Volume and Issue: 45(24), P. 6725 - 6741

Published: Jan. 1, 2016

Integration of the two-photon excitation (TPE) technique and nanomaterials to construct TPE nanoparticle-based photosensitizers for PDT is summarized reviewed.

Language: Английский

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Self-Targeting Fluorescent Carbon Dots for Diagnosis of Brain Cancer Cells

ACS Nano, Journal Year: 2015, Volume and Issue: 9(11), P. 11455 - 11461

Published: Oct. 12, 2015

A new type of carbon dots (CD-Asp) with targeting function toward brain cancer glioma was synthesized via a straightforward pyrolysis route by using D-glucose and L-aspartic acid as starting materials. The as-prepared CD-Asp exhibits not only excellent biocompatibility tunable full-color emission, but also significant capability C6 cells without the aid any extra molecules. In vivo fluorescence images showed high-contrast biodistribution 15 min after tail vein injection. much stronger fluorescent signal detected in site than that normal brain, indicating their ability to freely penetrate blood-brain barrier precisely tissue. However, its counterparts, CDs from (CD-G), L-asparic (CD-A), or L-glutamic (CD-Glu) have no low selectivity for glioma. Therefore, could act imaging agent noninvasive diagnosis. This work highlights potential application constructing an intelligent nanomedicine integration diagnostic, targeting, therapeutic functions.

Language: Английский

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Recent progress of nanomaterials for microwave absorption

Journal of Materiomics, Journal Year: 2019, Volume and Issue: 5(4), P. 503 - 541

Published: July 15, 2019

Microwave absorbing materials have received considerable interest over the years for their applications in stealth, communications, and information processing technologies. These often require functionalization at nanoscale so to achieve desirable dielectric magnetic properties which induce interaction with incident electromagnetic radiation. This article presents a comprehensive review on recent research progress of nanomaterials microwave absorption, including basic mechanism absorption (e.g., loss, dielectric/magnetic loss coupling), measurement principle fundamentals analysis, performance evaluation, common pathways: Debye relaxation, Eddy current natural resonance, size shape factors), advances bandwidth, reflection values, peak position) using various nanomaterials, such as carbon nanotubes, fibers, graphenes, oxides, sulfides, phosphides, carbides, polymers metal organic frameworks. Overall, this not only provides an introduction research, but also timely update nanomaterials.

Language: Английский

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Near‐Infrared‐Light‐Activatable Nanomaterial‐Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

Advanced Materials, Journal Year: 2018, Volume and Issue: 30(23)

Published: March 25, 2018

Abstract Cancer is one of the most deadly diseases threatening lives humans. Although many treatment methods have been developed to tackle cancer, each modality cancer has its own limitations and drawbacks. The development minimally invasive modalities for cancers remains a great challenge. Near‐infrared (NIR) light‐activated nanomaterial‐mediated phototherapies, including photothermal photodynamic therapies, provide an alternative means spatially temporally controlled treatments cancers. Nanomaterials can serve as nanocargoes delivery chemo‐drugs, diagnostic contrast reagents, organic photosensitizers, be used directly generate heat or reactive oxygen species tumors without need photosensitizers with NIR‐light irradiation. Here, current progress in NIR‐light‐activated therapy summarized. Furthermore, effects size, shape, surface functionalities nanomaterials on intracellular uptake, macrophage clearance, biodistribution, cytotoxicities, biomedical efficacies are discussed. use various types nanomaterials, such gold nanoparticles, carbon nanotubes, graphene, other inorganic nanostructures, combination therapeutic solid tumors, briefly reviewed.

Language: Английский

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