Towards a Better Understanding of the Human Health Risk of Per- and Polyfluoroalkyl Substances Using Organoid Models

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 393 - 393

Published: April 7, 2025

The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in the environment has garnered global public concern. Epidemiological studies have proved that exposure to PFAS is associated with human health risks. Although evidence demonstrated toxic mechanisms based on animal models traditional cell cultures, their limitations inter-species differences lack human-relevant microenvironments hinder understanding risks from exposure. There an increasing necessity explore alternative methodologies can effectively evaluate Human organoids derived stem cells accurately mimic sophisticated multicellular structures native organs, providing promising for toxicology research. Advanced combined innovative technologies are expected improve breadth depth toxicity.

Language: Английский

---

Diet quality in relation to serum perfluoroalkyl substance concentrations in Canadian preadolescents

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121790 - 121790

Published: May 1, 2025

Language: Английский

---

PFCs exposure and atherogenic risk characteristics in a high-fat diet condition: In vitro/in vivo models and population panel study

PNAS Nexus, Journal Year: 2025, Volume and Issue: 4(5)

Published: April 30, 2025

Abstract Perfluorinated compounds (PFCs) are a well-recognized environmental risk factor for atherosclerosis. However, corresponding atherogenic in susceptible populations consuming high-fat diets (HFDs) remains unclear. Here, we found that perfluorooctane sulfonic acid (PFOS), canonical PFCs, elevated the mice fed with HFD, which was characterized by an increased number of pro-inflammatory phenotype macrophages. We also macrophages exhibited metabolic reprogramming to glycolysis, attributed intracellular Fe2+ level. Mechanistic investigation revealed PFOS directly bound iron-storage site on ferritin heavy chain, subsequently weakening function. Notably, PFCs acidic substituents and short chains had higher risk, as evidenced crucial indicators observed population high triglyceride These findings highlight potential posed exposure HFD provide intervention target.

Language: Английский

---

PFOS impairs cardiac function and energy metabolism under high-fat diet: Insights into role of circulating macrophage emphasized by exposure distribution

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175139 - 175139

Published: July 30, 2024

Language: Английский

---

Enhanced selective photocatalytic reduction and oxidation of perfluorooctanoic acid on Bi/Bi5O7I decorated with poly (triazine imide)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136257 - 136257

Published: Oct. 22, 2024

Language: Английский

---