Cited by Absence of a Causal Link between Elemental Carbon Exposure and Short-Term Respiratory Toxicity in Human-Derived Organoids and Cellular Models

Absence of a Causal Link between Elemental Carbon Exposure and Short-Term Respiratory Toxicity in Human-Derived Organoids and Cellular Models DOI

et al.

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

Black carbon or elemental (EC) in the atmosphere plays an ambiguous role acute respiratory toxic effects. Here, we evaluate contribution of EC to short-term toxicity (including cytotoxicity and oxidative stress potency) fine particulate matter (PM2.5) on human tract using vitro airway organoids cell lines. The potency per unit mass, including char soot, is more than 2 orders magnitude lower that polycyclic aromatic hydrocarbons (PAHs), which are coemitted from incomplete combustion. contributes approximately 1 order less PM2.5 PAHs, despite its positive associations with PM2.5-induced (p < 0.0001). Furthermore, PAHs contribute 71.9 ± 12.2% 61.9 32.8% overall emitted typical burning solid liquid fuels, respectively, while significantly correlates content (r = 0.94, p 0.002). Hence, not a cause inducing toxicity, likely attributed PAHs. These findings provide causal evidence for understanding health risks associated exposure further benefit establishing efficient air pollution control policies.

Language: Английский

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