The interaction between metals and catecholamines: oxidative stress, DNA damage, and implications for human health DOI Creative Commons
Elena Cassera, Emanuele Ferrari, Davide A.L. Vignati

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111366 - 111366

Published: April 1, 2025

The interaction between metals and catecholamines plays a pivotal role in the generation of reactive oxygen species (ROS), leading to oxidative stress DNA damage. ROS are linked several diseases, including neurodegenerative disorders such as Parkinson's Alzheimer's diseases. This review examines how essential (iron, copper, zinc, manganese) few non-essential metal(loid)s (mercury, chromium, arsenic, aluminum, cadmium, nickel) contribute presence catecholamines. In metals, can cause modification, possibly resulting cell apoptosis, by taking part redox reactions oxidizing corresponding aminochrome with simultaneous production. Essential vital for physiological functions, but imbalances their homeostasis be harmful. Furthermore, commonly encountered through environmental or occupational exposure, exhibit significant toxicity. Previous studies on catecholamine-induced focused copper iron, this emphasizes need investigate other neurotoxic expand existing knowledge interactions catecholamines, Results from research could help prioritizing development new assessment methods associated adverse outcome pathways, reliably predict harmful effects human health, aiding therapeutical strategies. present work will shed light interplay damage different diseases hopefully fostering still understudied topic. Future should molecular mechanisms which these affect neuronal health disease pathogenesis.

Language: Английский

The interaction between metals and catecholamines: oxidative stress, DNA damage, and implications for human health DOI Creative Commons
Elena Cassera, Emanuele Ferrari, Davide A.L. Vignati

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111366 - 111366

Published: April 1, 2025

The interaction between metals and catecholamines plays a pivotal role in the generation of reactive oxygen species (ROS), leading to oxidative stress DNA damage. ROS are linked several diseases, including neurodegenerative disorders such as Parkinson's Alzheimer's diseases. This review examines how essential (iron, copper, zinc, manganese) few non-essential metal(loid)s (mercury, chromium, arsenic, aluminum, cadmium, nickel) contribute presence catecholamines. In metals, can cause modification, possibly resulting cell apoptosis, by taking part redox reactions oxidizing corresponding aminochrome with simultaneous production. Essential vital for physiological functions, but imbalances their homeostasis be harmful. Furthermore, commonly encountered through environmental or occupational exposure, exhibit significant toxicity. Previous studies on catecholamine-induced focused copper iron, this emphasizes need investigate other neurotoxic expand existing knowledge interactions catecholamines, Results from research could help prioritizing development new assessment methods associated adverse outcome pathways, reliably predict harmful effects human health, aiding therapeutical strategies. present work will shed light interplay damage different diseases hopefully fostering still understudied topic. Future should molecular mechanisms which these affect neuronal health disease pathogenesis.

Language: Английский

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