Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways

Cell chemical biology, Journal Year: 2017, Volume and Issue: 24(6), P. 712 - 724.e7

Published: May 25, 2017

Language: Английский

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Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays

Environment International, Journal Year: 2013, Volume and Issue: 55, P. 109 - 118

Published: March 28, 2013

Language: Английский

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Comparison of in vitro estrogenic activity and estrogen concentrations in source and treated waters from 25 U.S. drinking water treatment plants

The Science of The Total Environment, Journal Year: 2016, Volume and Issue: 579, P. 1610 - 1617

Published: Feb. 28, 2016

Language: Английский

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Microbial degradation of steroid sex hormones: implications for environmental and ecological studies

Microbial Biotechnology, Journal Year: 2019, Volume and Issue: 13(4), P. 926 - 949

Published: Oct. 30, 2019

Summary Steroid hormones modulate development, reproduction and communication in eukaryotes. The widespread occurrence persistence of steroid have attracted public attention due to their endocrine‐disrupting effects on both wildlife human beings. Bacteria are responsible for mineralizing steroids from the biosphere. Aerobic degradation relies O 2 as a co‐substrate oxygenases activate cleave recalcitrant steroidal core ring. To date, two oxygen‐dependent pathways – 9,10‐ seco pathway androgens 4,5‐ oestrogens been characterized. Under anaerobic conditions, denitrifying bacteria adopt 2,3‐ degrade different structures. Recent meta‐omics revealed that microorganisms able highly diverse ubiquitous ecosystems. This review also summarizes culture‐independent approaches using characteristic metabolites catabolic genes monitor biodegradation various

Language: Английский

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Polyamide 6/chitosan nanofibers as support for the immobilization of Trametes versicolor laccase for the elimination of endocrine disrupting chemicals

Enzyme and Microbial Technology, Journal Year: 2016, Volume and Issue: 89, P. 31 - 38

Published: March 8, 2016

Language: Английский

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Estrogens in municipal wastewater and receiving waters in the Beijing-Tianjin-Hebei region, China: Occurrence and risk assessment of mixtures

Journal of Hazardous Materials, Journal Year: 2019, Volume and Issue: 389, P. 121891 - 121891

Published: Dec. 12, 2019

Language: Английский

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Occurrence of emerging contaminants in highly anthropogenically influenced river Yamuna in India

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 782, P. 146741 - 146741

Published: March 30, 2021

Language: Английский

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The State of the Art and Emerging Trends in the Wastewater Treatment in Developing Nations

Water, Journal Year: 2022, Volume and Issue: 14(16), P. 2537 - 2537

Published: Aug. 18, 2022

Water is the founding fundamental of life and hence a basic need life. However, due to ever-rising population, industrialization has emerged as global issue. This problem notably escalated in developing countries. Their citizens face problems such floods, drought, poor water quality. Due quality sanitation problems, most health issues are caused by water-borne infections. In countries, untreated wastewater released into bodies or ground, thereby polluting natural resources. lack sufficient infrastructure, planning, funding, technologies overcome these problems. Additionally, urbanization megacities countries highly accelerated, but it disproportionate required resources for treating wastewater. this biological oxygen demand (BOD): chemical (COD) ratio increasing exponentially compared developed ones. Spreading awareness, education supporting relevant research, making stringent rules industries can alone solve

Language: Английский

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Review of endocrine disruptors on male and female reproductive systems

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2021, Volume and Issue: 244, P. 109002 - 109002

Published: Feb. 21, 2021

Language: Английский

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Bacterial estrogenesis without oxygen: Wood–Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(10)

Published: March 7, 2025

Androgen and estrogen, key sex hormones, were long thought to be exclusively produced by vertebrates. The O2-dependent aromatase that converts androgen estrogen (estrogenesis) has never been identified in any prokaryotes. Here, we report the finding of anaerobic estrogenesis a Peptococcaceae bacterium (Phosphitispora sp. strain TUW77) isolated from gut great blue-spotted mudskipper (Boleophthalmus pectinirostris). This exhibits testosterone fermentation pathways, transforming into estrogens androstanediol under conditions. Physiological experiments revealed TUW77 grows on testosterone, utilizing androgenic C-19 methyl group as both carbon source electron donor. genomic analysis three copies polycistronic gene cluster, abeABC (anaerobic bacterial estrogenesis), encoding components classic cobalamin-dependent methyltransferase system. These genes, highly expressed testosterone-fed conditions, show up 57% protein identity characterized EmtAB denitrifying Denitratisoma spp., known for methylating (the reverse reaction). Tiered transcriptomic proteomic analyses suggest removed is completely oxidized CO2 via oxidative Wood-Ljungdahl pathway (WLP), while reducing equivalents (NADH) fully reduce remaining androstanediol. Consistently, addition anthraquinone-2,6-disulfonate, an extracellular acceptor, cultures enabled complete conversion without accumulation oxidation). aromatase-independent bacteria suggests ancient WLP may have contributed emergence early biosphere.

Language: Английский

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