Photo-transformation of pharmaceutically active compounds in the aqueous environment: a review

Environmental Science Processes & Impacts, Journal Year: 2014, Volume and Issue: 16(4), P. 697 - 720

Published: Jan. 1, 2014

In the past few years, fate and transportation of pharmaceutically active compounds (PhACs) in aqueous environments have raised significant concerns among public, scientists regulatory groups. Photodegradation is an important removal process surface waters. This review summarizes last 10 years (2003-2013) studies on solar or solar-simulated photodegradation PhACs environments. The covered include: beta-blockers, antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), histamine H₂-receptor antagonists, lipid regulators, carbamazepine, steroid hormones, X-ray contrast media compounds. Kinetic studies, degradation mechanisms toxicity are three major topics involved this review. quantum yield for direct photolysis bimolecular reaction rate constants with reactive oxygen species (ROS), such as ˙OH radical singlet oxygen, also summarized. information not only to predict PhAC fate, but very useful advanced treatment technologies, ozone oxidation processes.

Language: Английский

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Annihilation luminescent Eu-MOF as a near-infrared electrochemiluminescence probe for trace detection of trenbolone

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 434, P. 134691 - 134691

Published: Jan. 15, 2022

Language: Английский

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Environmental Designer Drugs: When Transformation May Not Eliminate Risk

Environmental Science & Technology, Journal Year: 2014, Volume and Issue: 48(20), P. 11737 - 11745

Published: Oct. 2, 2014

ADVERTISEMENT RETURN TO ISSUEFeatureNEXTEnvironmental Designer Drugs: When Transformation May Not Eliminate RiskDavid M. Cwiertny*†, Shane A. Snyder‡§, Daniel Schlenk∥, and Edward P. Kolodziej*⊥#View Author Information† Civil Environmental Engineering, University of Iowa, 4105 Seamans Center, Iowa City, 52242, United States‡ Chemical Arizona, 1133 E. James Rogers Way, Tucson, Arizona 85721, States§ NUS Research Institute (NERI), National Singapore, 5A Engineering Drive 1, T-Lab Building, Singapore 117411∥ Department Sciences, California, Riverside, California 92521, States⊥ Interdisciplinary Arts Washington, Tacoma, 1900 Commerce Street, Washington 98402, States# 201 More Hall, Seattle, 98195, States*(D.M.C.) Phone: +1-319-335-1401; fax: +1-319-335-5660; e-mail: [email protected]*(E.P.K.) +1-253-692-5659; +1-253-692-5718; protected]Cite this: Environ. Sci. Technol. 2014, 48, 20, 11737–11745Publication Date (Web):September 12, 2014Publication History Published online2 October 2014Published inissue 21 2014https://doi.org/10.1021/es503425wCopyright © 2014 American SocietyRIGHTS & PERMISSIONSACS AuthorChoiceArticle Views17733Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit (2 MB) Get e-AlertsSUBJECTS:Bioactivity,Impurities,Physical chemical processes,Receptors,Steroids e-Alerts

Language: Английский

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Product-to-Parent Reversion of Trenbolone: Unrecognized Risks for Endocrine Disruption

Science, Journal Year: 2013, Volume and Issue: 342(6156), P. 347 - 351

Published: Sept. 27, 2013

Return of the Steroid Trace levels organic contaminants enter aquatic ecosystems from a variety sources, including runoff agricultural lands. When these compounds and their metabolites break down, it is generally assumed that they become inert pose less ecological risk. Qu et al. (p. 347 , published online 26 September) tracked sunlight-mediated transformation trenbolone acetate (TBA)—a common growth-promoting steroid given to beef cattle—across number conditions in laboratory field. degradation products were exposed dark following photodegradation, surprisingly reverted back TBA metabolites, analog steroidal similar with unknown biological effects.

Language: Английский

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Transformation of acesulfame in water under natural sunlight: Joint effect of photolysis and biodegradation

Water Research, Journal Year: 2014, Volume and Issue: 64, P. 113 - 122

Published: July 10, 2014

Language: Английский

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Occurrence, spatiotemporal distribution, and ecological risks of steroids in a large shallow Chinese lake, Lake Taihu

The Science of The Total Environment, Journal Year: 2016, Volume and Issue: 557-558, P. 68 - 79

Published: March 17, 2016

Language: Английский

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Multigenerational and Transgenerational Effects of Environmentally Relevant Concentrations of Endocrine Disruptors in an Estuarine Fish Model

Environmental Science & Technology, Journal Year: 2020, Volume and Issue: 54(21), P. 13849 - 13860

Published: Sept. 29, 2020

Many pollutants cause endocrine disruption in aquatic organisms. While studies of the direct effects toxicants on exposed organisms are commonplace, little is known about potential for toxicant exposures a parental (F0) generation to affect unexposed F1 or F2 generations (multigenerational and transgenerational effects, respectively), particularly estuarine fishes. To investigate this possibility, we inland silversides (Menidia beryllina) environmentally relevant (low ng/L) concentrations ethinylestradiol, bifenthrin, trenbolone, levonorgestrel from 8 hpf 21 dph. We then measured development, immune response, reproduction, gene expression, DNA methylation two subsequent following exposure. Larval exposure each compound resulted negative F0 generations, ethinylestradiol levonorgestrel, also. The specific endpoints that were responsive varied, but included increased incidence larval deformities, reduced growth survival, impaired function, skewed sex ratios, ovarian atresia, egg production, altered expression. Additionally, fish exhibited differences selected genes, across all three indicating epigenetic transfer effects. These findings suggest assessments multiple key determining full magnitude adverse contaminant early life.

Language: Английский

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Zinc-Based Metal–Organic Framework with MLCT Properties as an Efficient Electrochemiluminescence Probe for Trace Detection of Trenbolone

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(40), P. 14054 - 14060

Published: Sept. 29, 2022

In this work, we utilized polycyclic aromatic hydrocarbon (PAH) derivatives as ligands to develop a zinc-based metal–organic framework (Zn-MOF) an effective detection probe construct electrochemiluminescence (ECL) sensor for trenbolone detection. As traditional ECL emitters, PAHs and their have limited luminescence efficiency because of the aggregation-induced quenching (ACQ) effect. Therefore, Zn-PTC was designed by coordination 3,4,9,10-perylenetetracarboxylic (PTC) in MOF eliminate ACQ Meanwhile, formed based on ligand possessed metal-to-ligand charge-transfer (MLCT) effect, which could transfer energy Zn2+ strong luminescence. The calculated be approximately 2.2 times that (K4PTC). Second, Ag@Fe core–shell bimetallic nanocrystal prepared efficient activation persulfate (S2O82–), thereby generating more sulfate radicals (SO4•–) further promote emission. According characterizations, UV–vis fluorescence spectra, density functional theory calculations, signal amplification mechanisms were investigated. addition, NKFRGKYKC (NKF) introduced affinity directionally immobilize target antibodies, thus releasing specific sites Fab fragment enhance binding activity. Based above strategies, constructed biosensor exhibited high sensitivity, realizing trace TBE with wide range (10 fg/mL–100 ng/mL) low limit (3.28 fg/mL). This study provided important reference sensitive monitoring steroid pollutants environment.

Language: Английский

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A Portable Microfluidic-Based Electrochemiluminescence Sensor for Trace Detection of Trenbolone in Natural Water

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(36), P. 12531 - 12537

Published: Aug. 31, 2022

In this study, a portable electrochemiluminescence sensor chip was designed for trenbolone (TBE) trace detection in environmental water. First, stable ECL signal obtained with low-toxicity 3,4,9,10-perylenetetracarboxylic acid (PTCA) as luminophore and persulfate (S2O82-) coreactant. Second, hollow-structured Cu2MoS4 introduced coreaction accelerator to catalyze S2O82- reduction. The reversible conversion of the mixed-valence transition metal ions (Cu+/Cu2+ Mo4+/Mo6+) greatly promoted generation sulfate radical (SO4•-). Meanwhile, special porous structure possessed large specific surface area, thus enhancing its catalytic performance. Based on these enhancement mechanisms, strong acquired, which improved sensitivity constructed sensor. Importantly, microfluidic sensing detection, thereby improving practicality developed miniature portable, exhibiting high TBE wide linear range (10 fg/mL-100 ng/mL) lower limit (3.32 fg/mL). This great significance timely rapid analysis steroid pollutants natural

Language: Английский

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Abiotic transformation of kresoxim-methyl in aquatic environments: Structure elucidation of transformation products by LC-HRMS and toxicity assessment

Water Research, Journal Year: 2023, Volume and Issue: 233, P. 119723 - 119723

Published: Feb. 10, 2023

Language: Английский

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