Mitochondrial toxicity of triclosan on mammalian cells DOI Creative Commons

Charmaine Ajao,

Maria A. Andersson, В. В. Теплова

et al.

Toxicology Reports, Journal Year: 2015, Volume and Issue: 2, P. 624 - 637

Published: Jan. 1, 2015

Effects of triclosan (5-chloro-2′-(2,4-dichlorophenoxy)phenol) on mammalian cells were investigated using human peripheral blood mono nuclear (PBMC), keratinocytes (HaCaT), porcine spermatozoa and kidney tubular epithelial (PK-15), murine pancreatic islets (MIN-6) neuroblastoma (MNA) as targets. We show that (1–10 μg ml−1) depolarised the mitochondria, upshifted rate glucose consumption in PMBC, HaCaT, PK-15 MNA, subsequently induced metabolic acidosis. Triclosan a regression insulin producing into tiny pycnotic necrotic death. Short exposure to low concentrations (30 min, ≤1 μg/ml) paralyzed high amplitude tail beating progressive motility spermatozoa, within 30 min exposure, depolarized spermatozoan mitochondria hyperpolarised acrosome region sperm head flagellar fibrous sheath (distal part flagellum). Experiments with isolated rat liver showed impaired oxidative phosphorylation, downshifted ATP synthesis, uncoupled respiration provoked excessive oxygen uptake. These are 100–1000 fold lower those permitted consumer goods. The mitochondriotoxic mechanism differs from valinomycin, cereulide enniatins by not involving potassium ionophoric activity.

Language: Английский

Expanded Target-Chemical Analysis Reveals Extensive Mixed-Organic-Contaminant Exposure in U.S. Streams DOI Creative Commons
Paul M. Bradley, Celeste A. Journey, Kristin M. Romanok

et al.

Environmental Science & Technology, Journal Year: 2017, Volume and Issue: 51(9), P. 4792 - 4802

Published: April 12, 2017

Surface water from 38 streams nationwide was assessed using 14 target-organic methods (719 compounds). Designed-bioactive anthropogenic contaminants (biocides, pharmaceuticals) comprised 57% of 406 organics detected at least once. The 10 most-frequently anthropogenic-organics included eight pesticides (desulfinylfipronil, AMPA, chlorpyrifos, dieldrin, metolachlor, atrazine, CIAT, glyphosate) and two pharmaceuticals (caffeine, metformin) with detection frequencies ranging 66–84% all sites. Detected contaminant concentrations varied less than 1 ng L–1 to greater μg L–1, 77 278 having median 100 respectively. Cumulative detections ranged 4–161 compounds (median 70) 8.5–102 847 respectively, correlated significantly wastewater discharge, watershed development, toxic release inventory metrics. Log10 widely monitored HHCB, triclosan, carbamazepine explained 71–82% the variability in total number (linear regression; p-values: < 0.001–0.012), providing a statistical inference tool for unmonitored contaminants. Due multiple modes action, high bioactivity, biorecalcitrance, direct environment application (pesticides), designed-bioactive 41 per site cumulative concentrations) developed watersheds present aquatic health concerns, given their acknowledged potential sublethal effects sensitive species lifecycle stages low L–1.

Language: Английский

Citations

299
Laccases and peroxidases: The smart, greener and futuristic biocatalytic tools to mitigate recalcitrant emerging pollutants DOI
Rana Morsi, Muhammad Bilal, Hafiz M.N. Iqbal

et al.

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 714, P. 136572 - 136572

Published: Jan. 10, 2020

Language: Английский

Citations

275
Role of Environmental Contaminants in the Etiology of Alzheimer&#8217;s Disease: A Review DOI
Manivannan Yegambaram, Bhagyashree Manivannan, Thomas G. Beach

et al.

Current Alzheimer Research, Journal Year: 2015, Volume and Issue: 12(2), P. 116 - 146

Published: Feb. 24, 2015

Alzheimer’s dis ease (AD) is a leading cause of mortality in the developed world with 70% risk attributable to genetics. The remaining 30% AD hypothesized include environmental factors and human lifestyle patterns. Environmental possibly inorganic organic hazards, exposure toxic metals (aluminium, copper), pesticides (organochlorine organophosphate insecticides), industrial chemicals (flame retardants) air pollutants (particulate matter). Long term exposures these contaminants together bioaccumulation over an individual’s life-time are speculated induce neuroinflammation neuropathology paving way for developing AD. Epidemiologic associations between contaminant still limited. However, many vitro animal studies have identified effects at cellular level, revealing alterations pathways metabolisms associated that warrant further investigations. This review provides overview vitro, epidemiological on etiology AD, highlighting available data supportive long link development pathology. Keywords: Adult-onset disease, endocrine disruptors, contaminants, metals, neuropathology, Parkinson's pesticides, synergistic effects, toxins.

Language: Английский

Citations

234
The impact of triclosan on the spread of antibiotic resistance in the environment DOI Creative Commons

Daniel E. Carey,

Patrick J. McNamara

Frontiers in Microbiology, Journal Year: 2015, Volume and Issue: 5

Published: Jan. 15, 2015

Triclosan (TCS) is a commonly used antimicrobial agent that enters wastewater treatment plants (WWTPs) and the environment. An estimated 1.1x105 to 4.2x105 kg of TCS are discharged from these WWTPs per year in United States. The abundance along with its properties have given rise concern regarding impact on antibiotic resistance objective this review assess state knowledge multidrug environmental settings, including engineered environments such as anaerobic digesters. Pure culture studies reviewed paper gain insight into substantially smaller body research surrounding impacts microbial communities. studies, mainly pathogenic strains bacteria, demonstrate often associated resistance. Research lacking quantify current discharge environment, but it known can increase communities exposed TCS. plans proposed quantitatively define conditions under which selects for

Language: Английский

Citations

226
The Florence Statement on Triclosan and Triclocarban DOI Creative Commons
Rolf U. Halden,

Avery E. Lindeman,

Allison E. Aiello

et al.

Environmental Health Perspectives, Journal Year: 2017, Volume and Issue: 125(6)

Published: June 20, 2017

The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists medical professionals the hazards lack demonstrated benefit from common uses triclosan triclocarban. These chemicals may be used in thousands personal care consumer products as well building materials. Based extensive peer-reviewed research, this statement concludes that triclocarban are environmentally persistent endocrine disruptors bioaccumulate toxic to aquatic other organisms. Evidence humans ecosystems is presented along with recommendations intended prevent future harm triclosan, triclocarban, antimicrobial substances similar properties effects. Because antimicrobials can have unintended adverse health environmental impacts, they should only when provide an evidence-based benefit. Greater transparency needed product formulations, before incorporated into product, long-term ecological impacts evaluated. https://doi.org/10.1289/EHP1788.

Language: Английский

Citations

195
Triclocarban enhances short-chain fatty acids production from anaerobic fermentation of waste activated sludge DOI
Yali Wang, Dongbo Wang, Yiwen Liu

et al.

Water Research, Journal Year: 2017, Volume and Issue: 127, P. 150 - 161

Published: Oct. 11, 2017

Language: Английский

Citations

179
Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis DOI
Peng Zhang,

Liyang Zheng,

Yitao Duan

et al.

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 421, P. 126707 - 126707

Published: July 21, 2021

Language: Английский

Citations

114
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract DOI Creative Commons
Jianan Zhang, Morgan E. Walker, Katherine Z. Sanidad

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 10, 2022

Emerging research supports that triclosan (TCS), an antimicrobial agent found in thousands of consumer products, exacerbates colitis and colitis-associated colorectal tumorigenesis animal models. While the intestinal toxicities TCS require presence gut microbiota, molecular mechanisms involved have not been defined. Here we show commensal microbes mediate metabolic activation colon drive its toxicology. Using a range vitro, ex vivo, vivo approaches, identify specific microbial β-glucuronidase (GUS) enzymes pinpoint motifs required to metabolically activate gut. Finally, targeted inhibition bacterial GUS abolishes colitis-promoting effects TCS, supporting essential role proteins toxicity. Together, our results define mechanism by which contribute toxicity highlight importance considering contributions microbiota evaluating toxic potential environmental chemicals.

Language: Английский

Citations

80
Biochar-based composites for removing chlorinated organic pollutants: Applications, mechanisms, and perspectives DOI Creative Commons

Qingqing Song,

Fanying Kong,

Bing-Feng Liu

et al.

Environmental Science and Ecotechnology, Journal Year: 2024, Volume and Issue: 21, P. 100420 - 100420

Published: April 12, 2024

Chlorinated organic pollutants constitute a significant category of persistent due to their widespread presence in the environment, which is primarily attributed expansion agricultural and industrial activities. These are characterized by persistence, potent toxicity, capability for long-range dispersion, emphasizing importance eradication mitigate environmental pollution. While conventional methods removing chlorinated encompass advanced oxidation, catalytic bioremediation, utilization biochar has emerged as prominent green efficacious method recent years. Here we review biochar's role remediating typical organics, including polychlorinated biphenyls (PCBs), triclosan (TCS), trichloroethene (TCE), tetrachloroethylene (PCE), organochlorine pesticides (OCPs), chlorobenzenes (CBs). We focus on impact material properties adsorption mechanisms organics. This highlights use sustainable eco-friendly pollutants, especially when combined with biological or chemical strategies. Biochar facilitates electron transfer efficiency between microorganisms, promoting growth dechlorinating bacteria mitigating toxicity organics through adsorption. Furthermore, can activate processes such oxidation nano zero-valent iron, generating free radicals decompose compounds. observe broader application bioprocesses treating soil, reducing impacts. Conversely, water-based integrating proved more effective, leading superior purification results. contributes theoretical practical pollutants.

Language: Английский

Citations

66
Human Fetal Exposure to Triclosan and Triclocarban in an Urban Population from Brooklyn, New York DOI Creative Commons

Benny F. G. Pycke,

Laura A. Geer, Mudar Dalloul

et al.

Environmental Science & Technology, Journal Year: 2014, Volume and Issue: 48(15), P. 8831 - 8838

Published: June 27, 2014

Triclosan (TCS) and triclocarban (TCC) are antimicrobial agents formulated in a wide variety of consumer products (including soaps, toothpaste, medical devices, plastics, fabrics) that regulated by the U.S. Food Drug Administration (FDA) Environmental Protection Agency. In late 2014, FDA will consider regulating use both chemicals, which under scrutiny regarding lack effectiveness, potential for endocrine disruption, contribution to bacterial resistance antibiotics. Here, we report on body burdens TCS TCC resulting from real-world exposures during pregnancy. Using liquid chromatography tandem mass spectrometry, determined concentrations TCS, TCC, its human metabolites (2'-hydroxy-TCC 3'-hydroxy-TCC) as well manufacturing byproduct (3'-chloro-TCC) total (Σ-) after conjugate hydrolysis maternal urine cord blood plasma cohort 181 expecting mother/infant pairs an urban multiethnic population Brooklyn, NY recruited 2007-09. was detected 100% 51% samples hydrolysis. The interquartile range (IQR) highly similar IQR reported previously age-matched National Health Nutrition Examination Survey (NHANES) 2003 2004, but typically higher than general (detection frequency = 74.6%). Urinary levels here first time pregnancy, showing median concentration 0.21 μg/L. correlated with phase-I metabolite ∑-2'-hydroxy-TCC (r 0.49) ∑-3'-chloro-TCC C 0.79), strongly ∑-3'-hydroxy-TCC 0.99). This biomonitoring study presents burden data occurring pregnancy provides additional composite exposure (i.e., consumer-product environmental sources) maternal-fetal unit United States.

Language: Английский

Citations

165