Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(51)
Published: Nov. 8, 2023
The
exploration
of
value-added
conversions
naturally
abundant
amino
acids
has
received
considerable
attention
from
the
synthetic
community.
Compared
with
well-established
asymmetric
decarboxylative
transformation,
deaminative
transformation
still
remains
a
formidable
challenge,
mainly
due
to
lack
effective
strategies
for
C-N
bond
activation
and
potential
incompatibility
chiral
catalysts.
Here,
we
disclose
photoinduced
Cu-catalyzed
coupling
reaction
arylboronic
acids.
This
new
protocol
provides
series
significant
phenylacetamides
in
generally
good
yields
excellent
stereoselectivity
under
mild
green
conditions
(42-85
%
yields,
up
97
ee).
Experimental
investigations
theoretical
calculations
were
performed
reveal
crucial
role
additional
phenols
improving
catalytic
efficiency
enantiocontrol.
ACS Catalysis,
Journal Year:
2021,
Volume and Issue:
11(6), P. 3614 - 3619
Published: March 7, 2021
Thiocarbonylation
of
alkenes
offers
an
ideal
procedure
for
the
synthesis
thioesters.
However,
thiocarbonylation
alkenes,
especially
styrenes,
to
produce
valuable
linear
thioesters
has
remained
a
challenge.
In
this
Letter,
general
palladium-catalyzed
been
achieved.
Moderate
good
yields
desired
can
be
produced
from
readily
available
in
straightforward
manner.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(51)
Published: Oct. 27, 2022
In
contrast
to
previous
approaches
chiral
α-aryl
carboxylic
acids
that
based
on
reactions
using
hazardous
gases,
pressurized
setup
and
mostly
noble
metal
catalysts,
in
this
work,
a
nickel-catalyzed
general,
efficient
highly
enantioselective
carboxylation
reaction
of
racemic
benzylic
(pseudo)halides
under
mild
conditions
atmospheric
CO2
has
been
developed.
A
unique
2,2'-bipyridine
ligand
named
Me-SBpy
featuring
compact
polycyclic
skeleton
enabled
both
high
reactivity
stereoselectivity.
The
utility
method
demonstrated
by
synthesis
various
(30
examples,
up
95
%
yield
99
:
1
er),
including
profen
family
anti-inflammatory
drugs
transformations
the
as
key
intermediates.
Based
mechanistic
experimental
results,
plausible
catalytic
cycle
involving
Ni-complex/radical
equilibrium
Lewis
acid-assisted
activation
proposed.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: May 31, 2023
Novel
strategy
for
acid
chlorides
formation
that
do
not
use
carboxylic
acids
is
particularly
attractive
in
chemical
synthesis
but
remains
challenging.
Herein,
we
reported
the
development
of
a
highly
effective
Pd-catalyzed
hydrochlorocarbonylation
alkenes
with
CO
alkyl
chlorides.
Chlorosilane
and
AcOH
were
found
as
mild
HCl
source
reaction.
The
reaction
shows
broad
substrate
scope
produces
both
branched
linear
good
to
high
yields
upon
different
ligands
solvents.
Cooperating
follow-up
acylation
reactions,
offers
complementary
platform
diverse
carbonyl
compounds
from
alkenes.
Mechanistic
investigations
suggested
proceeded
though
palladium
hydride
pathway,
prompted
reductive
elimination
acyl-Pd-Cl
intermediate.
European Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(43)
Published: Sept. 8, 2023
Abstract
Palladium‐catalyzed
asymmetric
hydrofunctionalization
of
alkenes
is
one
the
most
powerful
and
straightforward
methods
to
forge
a
new
C−H
bond
C−X
(X=C,
N,
O,
F,
Si
etc)
bond,
which
provides
an
efficient
way
obtain
valuable
enantioenriched
molecules
from
cheap
readily
available
feedstocks.
Catalytic
simple
challenging
but
still
highly
sought
after.
This
review
will
mainly
focus
on
recent
advances
in
Palladium
catalyzed
over
past
decade,
including
hydroamination,
hydrooxygenation,
hydrofluorination,
hydrosilylation,
hydroarylation,
hydroalkenylation
hydrocarbonylation.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(51)
Published: Nov. 8, 2023
The
exploration
of
value-added
conversions
naturally
abundant
amino
acids
has
received
considerable
attention
from
the
synthetic
community.
Compared
with
well-established
asymmetric
decarboxylative
transformation,
deaminative
transformation
still
remains
a
formidable
challenge,
mainly
due
to
lack
effective
strategies
for
C-N
bond
activation
and
potential
incompatibility
chiral
catalysts.
Here,
we
disclose
photoinduced
Cu-catalyzed
coupling
reaction
arylboronic
acids.
This
new
protocol
provides
series
significant
phenylacetamides
in
generally
good
yields
excellent
stereoselectivity
under
mild
green
conditions
(42-85
%
yields,
up
97
ee).
Experimental
investigations
theoretical
calculations
were
performed
reveal
crucial
role
additional
phenols
improving
catalytic
efficiency
enantiocontrol.
