Recent Advances in Ni-Catalyzed Asymmetric Reductive Difunctionalization of Alkenes

Chinese Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 42(10), P. 3302 - 3302

Published: Jan. 1, 2022

Alkenes are cheap and easily available bulk industrial feedstocks.Difunctionalization of alkenes can rapidly construct complex molecules, which have broad applications in organic synthesis.Compared with traditional redox-neutral alkene difunctionalization, the reductive difunctionalization introduce two different electrophiles to both sides carbon-carbon double bond, has advantages mild reaction conditions, high functional group tolerance, no need for pre-prepared organometallic reagents.The latest research progress nickel-catalyzed is summarized.The development prospect prospected.

Language: Английский

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Nickel-Catalyzed Asymmetric Cross-Electrophile trans-Aryl-Benzylation of α-Naphthyl Propargylic Alcohols

ACS Catalysis, Journal Year: 2023, Volume and Issue: 13(10), P. 6795 - 6803

Published: May 3, 2023

Herein, we report a nickel-catalyzed asymmetric three-component trans-dicarbofunctionalization of β-substituted α-naphthyl propargylic alcohols using readily available aryl and benzyl halides as the coupling partners under reductive conditions. This cross-electrophile strategy enables synthesis various axially chiral allylic bearing tetrasubstituted olefinic unit in complete regio- E selectivity, well high enantiocontrol. Relying on hydroxyl group functional handle, such structural motifs are successfully derivatized into diverse functional-group-rich alkenes.

Language: Английский

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Advancing Heterogeneous Organic Synthesis With Coordination Chemistry‐Empowered Single‐Atom Catalysts

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract For traditional metal complexes, intricate chemistry is required to acquire appropriate ligands for controlling the electron and steric hindrance of active centers. Comparatively, preparation single‐atom catalysts much easier with more straightforward effective accesses arrangement control The presence coordination atoms or neighboring functional on supports' surface ensures stability single‐atoms their interactions individual substantially regulate performance Therefore, collaborative interaction between surrounding environment enhances initiation reaction substrates formation transformation crucial intermediate compounds, which imparts significant catalytic efficacy, rendering them a valuable framework investigating correlation structure activity, as well mechanism in organic reactions. Herein, comprehensive overviews both homogeneous complexes reactions are provided. Additionally, reflective conjectures about advancement synthesis also proposed present reference later development.

Language: Английский

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Synthesis of Multisubstituted Allenes via Nickel-Catalyzed Cross-Electrophile Coupling

ACS Catalysis, Journal Year: 2021, Volume and Issue: 11(21), P. 13355 - 13362

Published: Oct. 19, 2021

In this context, we report the successful application of a cross-electrophile strategy in synthesis multisubstituted allenes. Under catalysis nickel, reductive cross-coupling between propargyl carbonates and organoiodides provides an entry to prepare tri- or tetrasubstituted allenes without employing any pregenerated organometallics. Furthermore, also prove be suitable allenylating agents nickel-catalyzed asymmetric aryl-allenylation aryl-iodide-tethered unactivated alkenes, furnishing variety chiral benzene-fused cyclic compounds bearing quaternary allenyl-substituted stereogenic center highly enantioselective manner.

Language: Английский

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Nickel-catalyzed reductive cross-coupling of polyfluoroarenes with alkyl electrophiles by site-selective C–F bond activation

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 33(9), P. 4287 - 4292

Published: Feb. 3, 2022

Language: Английский

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