Ni-catalyzed propargylic substitution reaction: A general and versatile tool to assemble axially chiral phosphorus-containing allenes

Chem Catalysis, Journal Year: 2024, Volume and Issue: 4(3), P. 100903 - 100903

Published: Feb. 1, 2024

Language: Английский

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Kinetic Resolution of α,β-Unsaturated Tertiary Phosphine Oxides via Alkene E → Z Isomerization Catalyzed by a Photoexcited Chiral Copper Complex

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 4541 - 4549

Published: March 3, 2025

Language: Английский

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Ni-Catalyzed Enantioselective Allylic Alkylation of H-Phosphinates

Organic Letters, Journal Year: 2021, Volume and Issue: 23(22), P. 8683 - 8687

Published: Nov. 4, 2021

The asymmetric synthesis of P-stereogenic phosphinates through allylic alkylation H-phosphinates has been developed. With and acetates as the starting materials, a variety P-chiral were accessed in high enantioselectivities up to 92% ee generally yields. In addition, further study demonstrated applicability this protocol, including scale-up facile transformation chiral products from phosphine oxides with organolithium reagents under mild reaction conditions.

Language: Английский

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Manganese(i)-catalyzed access to 1,2-bisphosphine ligands

Chemical Science, Journal Year: 2022, Volume and Issue: 13(5), P. 1307 - 1312

Published: Jan. 1, 2022

Chiral bisphosphine ligands are of key importance in transition-metal-catalyzed asymmetric synthesis optically active products. However, the transition metals typically used scarce and expensive noble metals, while synthetic routes to access chiral phosphine cumbersome lengthy. To make homogeneous catalysis more sustainable, progress must be made on both fronts. Herein, we present first catalytic hydrophosphination α,β-unsaturated oxides presence a complex earth-abundant manganese(i). This system offers short two-step, one-pot sequence easily accessible structurally tunable 1,2-bisphosphines high yields enantiomeric excess. The resulting bidentate were successfully as part metal based organometallic catalysts.

Language: Английский

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Palladium-catalyzed diastereo- and enantioselective desymmetric hydrophosphination of cyclopropenes

Chem Catalysis, Journal Year: 2022, Volume and Issue: 2(11), P. 3163 - 3173

Published: Sept. 8, 2022

Language: Английский

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