Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(32), P. 6006 - 6012
Published: Aug. 5, 2022
A
novel
four-component
reaction
of
alkynes,
amines,
azides,
and
2H-azirines
has
been
developed
for
the
first
time
by
efficient
formation
four
C–N
bonds
in
one
step
under
mild
conditions,
rapidly
preparing
polyfunctionalized
triazoles
with
molecular
diversity
involving
three
different
intermediates
copper–acetylide,
copper–allenylidene,
copper–vinyl
nitrene.
Propargylic
ester
is
disclosed
as
a
"three-in-one"
building
block
possessing
triplicate
cycloaddition
nucleophilic
electrophilic
properties,
which
could
enable
such
transformation
high
yields,
broad
substrate
scope,
functionalization.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(21), P. 8156 - 8162
Published: Jan. 1, 2024
The
first
straightforward
strategy
for
the
synthesis
of
1,4-dicarbonyl
Z-alkenes
has
been
developed
via
an
electrochemical
cross-coupling
reaction
sulfoxonium
ylides
and
alkynes
with
water.
metal-free
protocol
showed
easy-to-handle
nature,
good
functional
group
tolerance,
high
Z-stereoselectivity,
which
is
rare
in
previous
cases.
proposed
mechanism
was
convincingly
established
by
carrying
out
a
series
control
experiments,
cyclic
voltammetry
density
theory
(DFT)
studies.
Unprecedented
diazoacetate
N
-heteroarenium
salts
are
synthesized
and
participate
in
catalytic
[2
+
1]
cycloadditions
[2,3]-sigmatropic
rearrangements,
providing
facile
access
to
otherwise
difficult-to-obtain
multi-functionalized
-heterocycles.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(43), P. 8036 - 8040
Published: Oct. 26, 2022
A
Ru-catalyzed
reaction
of
difluoroalkyl
diazo
compounds
with
Hantzsch
ester
under
visible
light
to
achieve
the
formation
α-fluorovinylphosphonates
via
a
radical
process
has
been
developed.
Mechanistic
experiments
and
density
functional
theory
calculations
reveal
that
generation
carbon
is
directly
through
hydrogen
atom
transfer
(HAT)
by
ester.
This
system
represents
first
example
radicals
from
Hantzsch-ester-assisted
HAT
also
demonstrates
new
radical-involved
pathway
for
compounds.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
11(2), P. 358 - 363
Published: Nov. 22, 2023
Herein,
we
present
a
versatile
approach
for
the
photoredox-catalyzed
deoxydisulfuration
of
primary,
secondary,
and
tertiary
alcohols,
utilizing
tetrasulfides
to
facilitate
efficient
synthesis
unsymmetrical
disulfides.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(32), P. 6006 - 6012
Published: Aug. 5, 2022
A
novel
four-component
reaction
of
alkynes,
amines,
azides,
and
2H-azirines
has
been
developed
for
the
first
time
by
efficient
formation
four
C–N
bonds
in
one
step
under
mild
conditions,
rapidly
preparing
polyfunctionalized
triazoles
with
molecular
diversity
involving
three
different
intermediates
copper–acetylide,
copper–allenylidene,
copper–vinyl
nitrene.
Propargylic
ester
is
disclosed
as
a
"three-in-one"
building
block
possessing
triplicate
cycloaddition
nucleophilic
electrophilic
properties,
which
could
enable
such
transformation
high
yields,
broad
substrate
scope,
functionalization.
