Aggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging

ACS Nano, Journal Year: 2025, Volume and Issue: 19(1), P. 281 - 306

Published: Jan. 2, 2025

A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome limitations traditional fluorescent probes but also improve boundaries high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior performance. This review delves into molecular mechanisms (AIE), demonstrating how strategic design unlocks exceptional and contrast, which crucial for distinguishing healthy diseased tissues. highlights key applications AIEgens, such as time-resolved imaging, second near-infrared window (NIR-II), advancement sensitivity to physical biochemical cue-responsive The development AIE technology promises transform healthcare early disease detection targeted therapies, potentially reshaping personalized medicine. paradigm shift biophotonics offers efficient tools decode complexities biological systems at level, bringing us closer a future where invisible becomes visible incurable treatable.

Language: Английский

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Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117252 - 117252

Published: Aug. 25, 2023

Fluorescent biosensors are powerful analytical tools that have been widely employed in a range of vitro and vivo biomedical applications. However, traditional fluorophores exhibit aggregation-caused quenching (ACQs) effects hinder their use the development more advanced fluorescent biosensors. The discovery by Prof. Ben Zhong Tang aggregation-induced emission (AIE) luminogen (AIEgen) opposite to those impacted ACQ provides unique opportunities for design novel "turn-on" These AIEgens thus attracted extensive interest from researchers seeking leverage properties produce effective biosensing molecules, strategies, associated A wide array with structures, functional groups, optical properties, applications developed recent years. In present review, we provide comprehensive overview advances field AIEgen-based biosensor discuss future clinical prospects these molecules. Through discussions, hope strong evidence-based foundation further efforts aimed at producing increasingly

Language: Английский

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Multifunctional Fluorescent Main-Chain Charged Polyelectrolytes Synthesized by Cascade C–H Activation/Annulation Polymerizations

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4208 - 4220

Published: Feb. 10, 2023

Fluorescent polyelectrolytes have attracted enormous attention as functional polymer materials. In contrast with the widely studied conjugated ionic groups in side chains, fluorescent main-chain charged (MCCPs) rarely been explored due to large synthetic difficulty. Herein, we develop a facile and atom-economical

Language: Английский

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Efficient Conversion of Inert Nitriles to Multifunctional Poly(5-amino-1,2,3-triazole)s via Regioselective Click Polymerization with Azide Monomers under Ambient Conditions

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(10), P. 6652 - 6664

Published: Feb. 29, 2024

Nitrile compounds are abundant, stable, cheap, and readily available natural chemical industrial sources. However, the efficient conversion of nitrile monomers to functional polymers is mostly limited due their inert reactivity, developing polymerizations based on under very mild conditions still a big challenge. In this work, facile powerful base-catalyzed acetonitrile-azide click polymerization was successfully established ambient conditions. This also enjoys merits short reaction time (15 min), 100% atom economy, transition-metal-free catalyst system, regioselectivity. A series poly(5-amino-1,2,3-triazole)s (PATAs) with high weight-average molecular weights (Mw, up 204,000) were produced in excellent yields (up 99%). The PATAs containing tetraphenylethene (TPE) moieties exhibit unique aggregation-induced emission (AIE) characteristics, which could be used sensitively detect Fe(III) ions low limit detection (1.205 × 10–7 M) specifically image lysosomes living cells. Notably, facilely post-modified primary amino groups polymer chains even through one-pot tandem reaction. Thus, work not only establishes new convert stable nitriles but generates versatile properties for diverse applications.

Language: Английский

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Rhodium(III)-Catalyzed Intramolecular Annulation and Aromatization for the Synthesis of Pyrrolo[1,2-a]quinolines

Organic Letters, Journal Year: 2023, Volume and Issue: 25(11), P. 1845 - 1849

Published: March 10, 2023

A rhodium(III)-catalyzed protocol for the synthesis of pyrrolo[1,2-a]quinolines through intramolecular annulation o-alkynyl amino aromatic ketones and subsequent aromatization is reported. This transformation builds pyrrole quinoline moieties pyrrolo[1,2-a]quinoline in one pot achieves a flexible introduction different substituent groups at 4- 5-positions on products that were difficult to prepare by other means. The reaction proceeds smoothly gram scale, are amenable downstream synthetic manipulations.

Language: Английский

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Towards non-traditional intrinsic luminescence luminogens from polystyrene derivative C5 skeletal polymers and ladder polymers with well-regulated microstructures

European Polymer Journal, Journal Year: 2024, Volume and Issue: 206, P. 112760 - 112760

Published: Jan. 21, 2024

Language: Английский

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Synthesis of Polycyclic Heteroarenes via Rh(III)-Catalyzed Twofold C-H Activation of 3-Aryl-2H-benzo[b][1,4]oxazines and Annulation with α-Diazo-β-ketoesters

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

An efficient Rh(III)-catalyzed annulation between 3-aryl-2H-benzo[b][1,4]oxazines and α-diazo-β-ketoesters was developed, affording a series of polycyclic heteroarenes in moderate to excellent yields with good functional group compatibility. The procedure featured high efficiency, redox neutrality, twofold ortho-C-H activation, dual [4 + 2] annulation. Moreover, several important intermediates products have been isolated as powerful evidence for the proposed reaction mechanism.

Language: Английский

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Construction of Rings via Metal‐Catalyzed C−H Annulation with Unsymmetrical Internal Alkynes: Selectivity and Applications

ChemCatChem, Journal Year: 2023, Volume and Issue: 15(21)

Published: Aug. 19, 2023

Abstract Selective and concise construction of ring systems that are ubiquitous skeletons across chemistry, drugs materials, is indispensable for human life. Of note, directed C−H annulation with alkynes the expedient delivery holds great importance, featuring step‐ atom‐economy, mild conditions, broad substrate scope. However, regioselectivity issues remained when using unsymmetrical annulation. Herein, we summarized recent achievements towards solving this problem by developing directing groups, metal catalysts, versatile traceless functionality ensure overall regioselectivity, enantioselectivity, efficiency, synthetic application. We hope concept will promote further development precise functional molecules alkynes.

Language: Английский

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Mimicking the light harvesting system for sensitive pattern recognition of monosaccharides

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 385, P. 133677 - 133677

Published: March 16, 2023

Language: Английский

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Ethynyl-Directed Dual C(sp³)–H Activation Polymerization to Construct Regio- and Stereoregular C(sp³)–C(sp³) Bond Polymers

Macromolecules, Journal Year: 2023, Volume and Issue: 57(1), P. 122 - 131

Published: Dec. 20, 2023

The establishment of facile, efficient, and precise synthetic approaches to selectively convert stable C–H bonds functional polymers has great significance in both chemistry material science especially by C(sp3)–H activation. Here, an efficient dual activation polymerization alkynes activated methylenes catalyzed Pd(PPh3)4/benzoic acid was successfully established with a 100% atom economy excellent regio- stereoselectivity. A series high-weight-average molecular-weight (Mw approximately 66,500) poly(aryl butene)s (PABs) sole E configuration were generated remarkable yields (approximately 99%). PABs exhibit good thermal stability, solubility, film-forming ability. In addition, the thin PAB films display high refractive indices (RI) up 1.7126 at 589 nm. Because this strong group tolerance, luminophores can be readily constructed into main chain empower multicolored luminescence various states. Notably, containing tetraphenylethene (TPE) moiety feature unique aggregation-induced emission (AIE) peculiarities, which could specifically sensitively detect Fe(III) ions low limit detection (LOD) 1.585 × 10–6 M.

Language: Английский

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