Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(18)
Published: May 1, 2024
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
cancer
treatment
that,
despite
its
significant
attention,
faces
limitations
in
penetration
depth,
which
restrict
effectiveness.
Herein,
it
found
that
gold
nanobipyramid
(AuNBs)
coated
with
TiO
Small,
Journal Year:
2023,
Volume and Issue:
20(20)
Published: Dec. 10, 2023
Due
to
the
inherent
low
immunogenicity
and
immunosuppressive
tumor
microenvironment
(TME)
of
malignant
cancers,
clinical
efficacy
application
immunotherapy
have
been
limited.
Herein,
a
bimetallic
drug-gene
co-loading
network
(Cu/ZIF-8@U-104@siNFS1-HA)
is
developed
that
increased
intracellular
labile
iron
pool
(LIP)
enhanced
weakly
acidic
TME
by
co-suppressing
dual
enzymatic
activities
carbonic
anhydrase
IX
(CA
IX)
cysteine
desulfurylase
(NFS1),
inducing
safe
efficient
initial
immunogenic
ferroptosis.
During
this
process,
Cu
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(18)
Published: May 1, 2024
Photodynamic
therapy
(PDT)
is
a
minimally
invasive
cancer
treatment
that,
despite
its
significant
attention,
faces
limitations
in
penetration
depth,
which
restrict
effectiveness.
Herein,
it
found
that
gold
nanobipyramid
(AuNBs)
coated
with
TiO