Combinatorial Ligand Assisted Simultaneous Control of Axial and Central Chirality in Highly Stereoselective C−H Allylation DOI
Trisha Bhattacharya,

Supratim Ghosh,

Subhabrata Dutta

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 136(2)

Published: Nov. 24, 2023

Abstract The significance of stereoselective C−H bond functionalization thrives on its direct application potential to pharmaceuticals or complex chiral molecule synthesis. Complication arises when there are multiple stereogenic elements such as a center and an axis chirality control. Over the years cooperative assistance ligands has been applied control only centers. In this work, we harness essence ligand approach two different in same by atroposelective allylation synthesize axially biaryls from racemic precursor. crucial roles played phosphoric acid amino concert helped us obtain one major stereoisomer out four distinct possibilities.

Language: Английский

Combinatorial Ligand Assisted Simultaneous Control of Axial and Central Chirality in Highly Stereoselective C−H Allylation DOI
Trisha Bhattacharya,

Supratim Ghosh,

Subhabrata Dutta

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 136(2)

Published: Nov. 24, 2023

Abstract The significance of stereoselective C−H bond functionalization thrives on its direct application potential to pharmaceuticals or complex chiral molecule synthesis. Complication arises when there are multiple stereogenic elements such as a center and an axis chirality control. Over the years cooperative assistance ligands has been applied control only centers. In this work, we harness essence ligand approach two different in same by atroposelective allylation synthesize axially biaryls from racemic precursor. crucial roles played phosphoric acid amino concert helped us obtain one major stereoisomer out four distinct possibilities.

Language: Английский

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