Chemical and Pharmaceutical Bulletin,
Journal Year:
2024,
Volume and Issue:
72(3), P. 311 - 312
Published: March 15, 2024
An
improvement
of
the
two-photon
excitation
was
achieved
using
8-azacoumarin-type
caged
compounds,
which
showed
large
values
uncaging
action
cross-section
(δu
>0.1
Goeppert–Mayer
(GM)).
In
particular,
7-hydroxy-6-iodo-8-azacoumarin
(8-aza-Ihc)-caged
compound
an
excellent
value
=
1.28
GM).
Therefore,
photolabile
protecting
groups
(PPGs)
can
be
used
as
sources.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 479 - 479
Published: March 31, 2024
Over
the
past
few
decades,
photodynamic
therapy
(PDT)
has
evolved
as
a
minimally
invasive
treatment
modality
offering
precise
control
over
cancer
and
various
other
diseases.
To
address
inherent
challenges
associated
with
PDT,
researchers
have
been
exploring
two
promising
avenues:
development
of
intelligent
photosensitizers
activated
through
light-induced
energy
transfers,
charges,
or
electron
disruption
photosensitive
bonds.
Moreover,
there
is
growing
emphasis
on
bioorthogonal
delivery
activation
within
tumors,
enabling
targeted
deployment
these
systems
in
specific
tissues,
thus
achieving
highly
PDT.
This
concise
review
highlights
advancements
made
last
decade
realm
light-activated
photosensitizers,
comparing
their
efficacy
shaping
future
directions
advancement
therapy.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Feb. 19, 2025
Abstract
The
ability
to
control
the
activity
of
kinases
spatially
and
temporally
is
essential
elucidate
role
signalling
pathways
in
development
physiology.
Progress
this
direction
has
been
hampered
by
lack
tools
manipulate
kinase
a
highly
controlled
manner
vivo.
Here
we
report
strategy
modify
BI2536,
well
characterized
inhibitor
conserved
mitotic
Polo-like
1
(Plk1).
We
introduce
same
coumarin
photolabile
protecting
group
(PPG)
at
two
positions
inhibitor.
At
one
position,
prevents
interaction
with
Plk1,
second
it
masks
an
added
carboxylic
acid,
important
for
cellular
retention.
Exposure
light
results
removal
both
PPGs,
leading
activation
its
trapping
inside
cells.
demonstrate
efficacy
caged
three-dimensional
spheroid
cultures:
uncaging
single
pulse,
can
inhibit
Plk1
arrest
cell
division,
dynamic
process,
spatio-temporal
control.
Our
design
be
applied
other
small
molecules,
providing
solution
their
living
cells
unprecedented
precision.
RSC Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
covers
the
history
of
light
therapy,
emergence
photopharmacology,
its
methods,
and
challenges.
Current
advancements
show
promise
for
treating
diseases
like
cancer
with
precision
minimal
side
effects.
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
68(9), P. 9741 - 9754
Published: April 28, 2025
Photocleavable
protecting
groups
hold
great
promise
in
photopharmacology
to
control
the
release
of
bioactive
molecules
from
their
caged
precursors
within
specific
subcellular
compartments.
Herein,
we
describe
a
series
photocages
based
on
COUPY
scaffold,
incorporating
chlorambucil
(CLB)
and
4-phenylbutyric
acid
(4-PBA)
as
payloads
that
can
be
efficiently
activated
with
visible
light.
Confocal
microscopy
confirmed
preferential
accumulation
CLB
4-PBA
N-hexyl
mitochondria,
which
exhibited
remarkable
phototoxicity
against
cancer
cells
upon
green-yellow
light
irradiation,
IC50
values
nanomolar
range.
This
effect
was
attributed
synergistic
mechanism
involving
photorelease
intrinsic
photogeneration
Type
I
II
ROS
by
scaffold
mitochondria.
Thus,
COUPY-caged
derivatives
underscore
potential
COUPY-caging
versatile
platform
develop
innovative
light-activated
agents
operating
simultaneously
through
photodynamic
therapy
photoactivated
chemotherapy.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(33), P. 23376 - 23386
Published: Aug. 8, 2024
Photocontrolled
deprotection
of
specific
functional
groups
has
garnered
significant
interest
over
the
past
two
decades.
Notably,
selective
distinct
based
on
wavelength
emerged
as
a
prominent
focus
in
recent
research.
The
achievement
this
objective
primarily
involved
utilization
linker-based
bichromophoric
systems
and
diverse
cocktail
mixtures
photoresponsive
protecting
(PRPGs),
each
responsive
to
varying
wavelengths
light.
Herein,
we
present
first
wavelength-selective
monochromophoric
system
hydroxanthene
moiety,
enabling
release
functionalities
under
450
600
nm
light,
respectively.
mechanism
photodegradation
was
thoroughly
investigated
by
1H
NMR,
UV–vis,
fluorescence
spectroscopy,
suggesting
proton-coupled
electron
transfer
photorelease
step
arylmethyl
type
second
step.
utility
xanthene-based
PRPGs
demonstrated
multistep
degradation
microparticles
dual-color
tuning
polymer
chain
architecture,
thus
opening
an
avenue
design
advanced
photoreactive
wavelength-controlled
for
applications
soft
matter
materials.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 7128 - 7140
Published: May 20, 2023
Releasing
bioactive
molecules
in
specific
subcellular
locations
from
the
corresponding
caged
precursors
offers
great
potential
photopharmacology,
especially
when
using
biologically
compatible
visible
light.
By
taking
advantage
of
intrinsic
preference
COUPY
coumarins
for
mitochondria
and
their
long
wavelength
absorption
region,
we
have
synthesized
fully
characterized
a
series
COUPY-caged
model
compounds
to
investigate
how
structure
coumarin
caging
group
affects
rate
efficiency
photolysis
process.
Uncaging
studies
yellow
(560
nm)
red
light
(620
phosphate-buffered
saline
medium
demonstrated
that
incorporation
methyl
position
adjacent
photocleavable
bond
is
particularly
important
fine-tune
photochemical
properties
group.
Additionally,
use
version
protonophore
2,4-dinitrophenol
allowed
us
confirm
by
confocal
microscopy
photoactivation
can
occur
within
living
HeLa
cells
upon
irradiation
with
low
doses
The
new
photolabile
protecting
groups
presented
here
complement
toolbox
therapeutic
applications
since
they
will
facilitate
delivery
photocages
active
into
mitochondria.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(18), P. 6897 - 6905
Published: Jan. 1, 2024
An
all-photonic
method
is
described,
in
which
(i)
the
release
of
an
active
kinase
inhibitor
controlled
externally
with
light;
and
(ii)
fluorescence
employed
to
report
both
binding
its
corresponding
target.
