Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 11, 2024
Abstract
Trivalent
phosphine
catalysis
is
mostly
utilized
to
activate
the
carbon‐carbon
multiple
bonds
form
carbanion
intermediate
species
and
highly
sensitive
certain
variables.
Random
manual
multi‐variables
are
critical
for
understanding
batch
disabled
regeneration
of
trivalent
chemistry.
We
need
artificial
intelligence‐based
system
which
can
change
variable
based
on
previously
conducted
failed
experiment.
Herein,
we
report
an
auto‐optimized
electro‐micro‐flow
reactor
platform
in‐situ
reduction
stable
P(V)
oxide
P(III)
further
method
Corey‐Fuchs
reaction.
Chemical Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
A
transition-metal-free
protocol
for
the
unsymmetrical
radical
1,3-difunctionalization
of
alkenes
has
been
established
first
time
in
form
1,3-difluoroalkylcarboxylation
by
a
photocatalytic
three-component
reaction
allyl
formates,
trifluoroacetanilides,
and
cesium
formate.
This
employs
formate
as
carboxylating
reagent
trifluoroacetanilide
difluoroalkylating
via
C-F
bond
activation.
As
result,
series
previously
inaccessible
difluorinated
adipic
acid
derivatives
can
be
easily
efficient
prepared.
Mechanism
studies
reveal
that
triple
kinetic-controlled
self-ordering
is
key
to
this
unique
reaction.
sorting
involves
fast
initiation
CO2
anion
its
chemoselective
addition
reduction,
followed
slow
generation
fluoroalkyl
chemo-/regioselective
addition.
Notably,
strategy
also
suitable
cyclic
through
diastereoselectively
constructing
two
or
three
consecutive
stereocenters.
Green Synthesis and Catalysis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Given
the
significance
of
oxacyclic
frameworks
in
molecular
scaffolds
and
drug
discovery,
it
is
intriguing
to
precisely
construct
manipulate
such
ring
systems
chemical
research.
In
this
area,
intermolecular,
multicomponent
cyclization
for
synthesis
diversely
substituted
seven-membered
oxacycles
under
simple
conditions
still
a
challenge.
Here,
we
report
dual
photoredox/Brønsted
acid
relay
catalytic
strategy
situ
generation
ortho-quinone
methides
subsequent
(4+3)
with
2-indolylalcohols.
one-pot
reaction,
two
C-C
one
C-O
bonds
are
formed,
providing
de
novo
access
various
biologically
important
indole-fused,
oxygen-containing
heterocycles.
By
virtue
chiral
phosphoric
acid,
an
asymmetric
version
can
also
be
achieved
good
excellent
levels
enantioselectivity
(up
96:4
er).
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(13), P. 3717 - 3723
Published: Jan. 1, 2024
Visible-light-induced
phosphine-catalyzed
radical
cyclization
of
bromodifluoroacyl
arenes
with
diverse
alkenes,
affording
a
variety
cyclic
gem
-difluoroacyl
scaffolds
in
good
to
excellent
yields.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(41)
Published: July 18, 2024
Abstract
Although
highly
appealing
for
rapid
access
of
molecular
complexity,
multi‐functionalization
alkenes
that
allows
incorporation
more
than
two
functional
groups
remains
a
prominent
challenge.
Herein,
we
report
novel
strategy
merges
dipolar
cycloaddition
with
photoredox
promoted
radical
ring‐opening
remote
C(sp
3
)−H
functionalization,
thus
enabling
smooth
1,2,5‐trifunctionalization
unactivated
alkenes.
A
regioselective
[3+2]
anchors
reaction
trigger
onto
alkene
substrates.
The
subsequent
halogen
atom
transfer
(XAT)
selectively
initiates
process,
which
is
followed
by
series
1,5‐hydrogen
(1,5‐HAT)
and
intermolecular
fluorine
(FAT)
events.
With
this
method,
site‐selective
introduction
three
different
accomplished
broad
spectrum
valuable
β‐hydroxyl‐ϵ‐fluoro‐nitrile
products
are
synthesized
from
readily
available
terminal
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(17), P. 12802 - 12807
Published: Aug. 22, 2023
The
mechanism
of
the
1,2-spin-center
shift
in
carbohydrate
systems
was
studied
with
a
fluorenylcyclopropyl
radical
clock.
1,2-rearrangement
acyl
fluorenylcyclopropane
group
without
opening
cyclopropane
ring
provides
strongest
evidence
that
occurs
through
concerted
transition
state
intermediacy
1,3-dioxolanyl
radical.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(1), P. 148 - 153
Published: Dec. 9, 2023
Abstract
An
EDA
complex
comprising
N
‐allyl
bromodifluoroacetamides
and
tertiary
alkyl
amine
was
exploited
to
facilitate
annulative
difunctionalization
reaction
under
visible‐light
irradiation.
This
external
photocatalyst‐free
methodology
garners
olefin‐olefin
coupling
featuring
a
radical
Truce‐Smiles
rearrangement
produced
long‐chain
functionalized
gem
‐difluoropyrrolidones
from
N‐
substituted
methacryloyl
sulfonamides,
while
simple
‐aryl
methacrylamides
furnished
pyrrolidinone‐oxindole
hybrid
lactams
in
high
yields.
Mechanistic
investigations
substantiate
combined
mechanism,
involving
charge‐transfer
complex‐based
cascade,
alongside
an
α‐aminoalkyl
radical‐triggered
XAT
process,
exhibiting
quantum
yield
value
of
1.48.
