Abstract
Developing
targeted
treatment
strategies
for
glioblastoma
(GBM)
is
of
significant
importance
but
remains
highly
challenging.
Herein,
we
propose
a
novel
size-variable
self-feedback
nanorobot
system
tailored
GBM
treatment,
leveraging
the
unique
high-calcium
microenvironment
GBM.
These
nanomotors
consist
three
main
components:
degradable
lipid
shell,
core
with
motion
ability,
and
drug
curcumin
(inhibiting
efflux
Ca2+).
The
shell
incorporates
nitric
oxide-releasing
(NOR)
NO-responsive
(NOD).
NOR
catalyzed
by
inducible
oxide
synthase
(iNOS)
to
release
NO.
NOD
degrades
in
response
self-released
composed
L-arginine
(L-Arg)
derivatives
zwitterionic
monomers
rich
carboxyl
groups
(facilitating
Ca2+
recruitment)
(PAC
NMs).
Initially,
larger
(~
500
nm)
can
penetrate
blood-brain
barrier
through
chemotaxis,
driven
high
expression
iNOS
microenvironment.
During
gradually
as
NO
accumulates,
releasing
smaller
PAC
NMs
50
nm).
target
mitochondria,
where
they
recruit
Ca²⁺
induce
mitochondrial
mineralization
conjunction
curcumin,
ultimately
leading
tumor
cell
death
inhibiting
progression.
This
work
may
provide
new
strategy
development
GBM-specific
methods.
