Synlett,
Journal Year:
2023,
Volume and Issue:
35(04), P. 445 - 450
Published: Aug. 1, 2023
Abstract
Cooperative
NHC
and
photoredox
catalysis
has
gained
significant
attention
as
an
emerging
research
field
in
recent
years.
Herein,
we
report
a
cyclizing
aminoacylation
of
alkenes,
which
is
enabled
through
the
combination
these
two
catalytic
modes.
The
key
step
radical/radical
cross-coupling
between
persistent
ketyl
radical
transient
benzylic
or
aliphatic
C-radical,
generated
cyclization
oxidatively
formed
amidyl
radical.
Several
carbamates,
amides
sulfonamides
containing
alkene
moiety
different
acyl
fluorides
can
be
used
substrates.
resulting
products
are
obtained
moderate
to
good
yields.
ACS Catalysis,
Journal Year:
2023,
Volume and Issue:
14(1), P. 547 - 553
Published: Dec. 26, 2023
Direct
transformations
of
readily
available
amines
or
amides
via
C–H
bond
functionalization
could
provide
a
fast
route
for
accessing
complex
molecules.
While
various
groups
have
been
successfully
incorporated
into
the
α
position
nitrogen
atom
with
photoredox
system
activation,
couplings
functionalized
alkyl
halides
are
still
very
challenging.
Herein,
we
report
direct
and
convenient
protocol
β-amino
boronates
through
C(sp3)–C(sp3)
coupling
α-bromoboronates.
The
mild
conditions
allow
good
functional
group
tolerance
broad
scope.
application
method
in
late-stage
modification
molecules
further
demonstrates
its
great
potential
organic
synthesis.
Mechanistic
studies
were
also
conducted,
catalytic
cycle
is
proposed.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(4), P. 790 - 790
Published: Feb. 8, 2024
Monofluoromethyl
(CH2F)
motifs
exhibit
unique
bioactivities
and
are
considered
privileged
units
in
drug
discovery.
The
radical
monofluoromethylative
difunctionalization
of
alkenes
stands
out
as
an
appealing
approach
to
access
CH2F-containing
compounds.
However,
this
strategy
remains
largely
underdeveloped,
particularly
under
metal-free
conditions.
In
study,
we
report
on
visible
light-mediated
three-component
monofluoromethylation/acylation
styrene
derivatives
employing
NHC
organic
photocatalyst
dual
catalysis.
A
diverse
array
α-aryl-β-monofluoromethyl
ketones
was
successfully
synthesized
with
excellent
functional
group
tolerance
selectivity.
mild
CH2F
generation
from
NaSO2CFH2
holds
potential
for
further
applications
fluoroalkyl
chemistry.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(8), P. 4289 - 4289
Published: April 12, 2024
Dyes
based
on
quinoline
and
quinoxaline
skeletons
were
designed
for
application
as
visible
light
photoinitiators.
The
obtained
compounds
absorb
electromagnetic
radiation
the
border
between
ultraviolet
light,
which
allows
use
of
dental
lamps
sources
during
initiation
photopolymerization
reaction.
Their
another
desirable
feature
is
ability
to
create
a
long-lived
excited
state,
enables
chain
reaction
proceed
through
mechanism
intermolecular
electron
transfer.
In
two-component
photoinitiating
systems,
in
presence
an
donor
or
hydrogen
atom
donor,
synthesized
show
excellent
abilities
photoinitiate
polymerization
acrylates.
control
tests,
efficiency
using
modified
derivatives
comparable
that
typical,
commercial
photoinitiator
dentistry,
camphorquinone.
Moreover,
tested
requires
small
amount
(only
0.04%
by
weight)
initiate
research
also
showed
significant
acceleration
process
shortening
time.
practice,
this
means
new
initiating
systems
can
be
used
much
lower
concentrations
without
slowing
down
speed
obtaining
polymer
materials.
It
worth
emphasizing
these
two
features
system
allow
cost
reduction
reducing
financial
outlays
both
materials
(photoinitiators)
electricity.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(26), P. 17566 - 17572
Published: June 17, 2024
Acceptorless
dehydrogenative
coupling
reactions
between
C-H
bonds
offer
straightforward
and
atom-economical
methods
connecting
readily
available
materials
while
liberating
gaseous
hydrogen
as
the
sole
byproduct.
Despite
growing
interest
in
such
transformations,
their
realization
still
poses
a
significant
challenge.
Here
we
report
photoinduced
reaction
of
alkylamines
with
primary
alcohols.
adjacent
to
nitrogen
oxygen
are
site-selectively
cleaved,
C-C
bond
is
created
carbon
atoms
cross-selective
manner
produce
α-amino
ketones.
Diverse
polar
functionalities
esters,
amides,
carboxylic
acids
survived,
demonstrating
broad
applicability
present
method.
Synlett,
Journal Year:
2023,
Volume and Issue:
35(04), P. 445 - 450
Published: Aug. 1, 2023
Abstract
Cooperative
NHC
and
photoredox
catalysis
has
gained
significant
attention
as
an
emerging
research
field
in
recent
years.
Herein,
we
report
a
cyclizing
aminoacylation
of
alkenes,
which
is
enabled
through
the
combination
these
two
catalytic
modes.
The
key
step
radical/radical
cross-coupling
between
persistent
ketyl
radical
transient
benzylic
or
aliphatic
C-radical,
generated
cyclization
oxidatively
formed
amidyl
radical.
Several
carbamates,
amides
sulfonamides
containing
alkene
moiety
different
acyl
fluorides
can
be
used
substrates.
resulting
products
are
obtained
moderate
to
good
yields.
