A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 404 - 416

Published: Feb. 10, 2025

Language: Английский

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Endoplasmic Reticulum-Targeted Polymer-Manganese Nanocomplexes for Tumor Immunotherapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Manganese ions (Mn2+) are an immune activator that enhances the activation of both cGAS and STING proteins. The signaling subsequential responses predominantly associated with endoplasmic reticulum (ER). Therefore, ER targeting Mn2+ in subcellular compartments would promote pathways. Herein, we report design ER-targeted manganese-based nanocomplexes (NCs) by complexation a zwitterionic polymer, poly[2-(N-oxide-N,N-dimethylamino) ethyl methacrylate] (OPDMA). Mn/OPDMA (Mn/OPDMA NCs) keep long blood circulation for tumor accumulation trigger adsorption-mediated transcytosis extravasation deep penetration. Notably, tumor-associated macrophages, NCs can preferentially translocate to their ERs, significantly enhancing cGAS-STING pathway macrophage polarization IFN-β secretion. In mouse colon hepatocellular cancer models, intravenously administrated efficiently remodel microenvironment, greatly retard growths 2.4- 5-fold, prolong survivals compared free Mn2+-treated mice. This study provides delivery achieves robust and, thus, potent systemic inhibition without toxicity Mn2+.

Language: Английский

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Adoptive cell transfer of piezo-activated macrophage rescues immunosuppressed rodents from life-threating bacterial infections

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 4, 2025

Bacterial infections pose a significant threat to human health. Catalytic antibacterial nanoparticles that generate reactive oxygen species (ROS) are emerging, as promising therapeutic approach in treating bacterial infection by boosting the innate immune defenses. However, interaction between cells and these catalytic remains poorly understood. Here, using rodent models of infection, we test antimicrobial properties ultrasound-responsive piezo-catalytic (piezoNP). We show piezoNPs strongly interact with macrophages within subcutaneous abscesses caused Staphylococcus aureus (S. aureus) infections, demonstrate this enhances macrophage-mediated phagocytosis killing activity through intracellular piezocatalysis. Moreover, use piezo-activated (piezoMϕ) adoptive cell therapy (ACT) for various immunosuppressive including sepsis, pneumonia peritonitis. Our study thus highlights potential application alternative conventional treatment effectively modulate responses engineer immunotherapy purposes.

Language: Английский

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An Oxidative Stress Nanoamplifier with Efficient Non-Fenton-Type Hydroxyl Radical Generation and Sulfur Dioxide Release for Synergistic Treatment of Tumor

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Overcoming tumor antioxidant defenses remains a critical challenge for reactive-oxygen-species-mediated therapies. To address this problem, herein, theranostic nanomedicine designated as CCM@MIB has been elaborately constructed. Homologous cancer cell membrane (CCM) camouflage significantly enhances the selective accumulation of at sites. In response to microenvironment (TME), controllably releases Mn ions and sulfur dioxide (SO2) molecules. The released catalyze self-oxidation isoniazid generate highly toxic •OH, while SO2 produced by benzothiazole sulfinate effectively disrupts defense systems. catalase-like activity endowed increased intracellular •O2– level induced further promote •OH production. Therefore, such an intellectual combination non-Fenton-type catalytic therapy gas amplifies oxidative stress efficiently suppresses growth. Additionally, TME-activated magnetic resonance imaging contrast performance is beneficial guiding antitumor treatment. This considerate strategy designed in our work provides ingenious paradigm development efficient

Language: Английский

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Silver niobate/platinum piezoelectric heterojunction enhancing intra-tumoral infiltration of immune cells for transforming “cold tumor” into “hot tumor”

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137303 - 137303

Published: March 12, 2025

Language: Английский

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