The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(11), P. 8267 - 8271
Published: May 16, 2024
A
fluorescence
lifetime
imaging
microscopy
(FLIM)
technique
characterizes
surfactant-dependent
partitioning
of
organics
in
a
system
that
mimics
Negishi-like
cross-coupling
reaction
water,
under
synthetic
concentrations,
with
emulsion
droplets.
Experimental
data
were
not
predictable
from
simple
hydrophilic–lipophilic
balances.
The
ionic
surfactant
cetrimonium
chloride
suppressed
the
reactivity
metallic
zinc
surface,
presumably
through
competitive
binding
and
concurrent
coating,
finding
may
contribute
to
reduced
performance
surfactants
bench-scale
coupling
reaction.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(2), P. 301 - 317
Published: Jan. 16, 2024
Water
is
considered
to
be
the
most
sustainable
and
safest
solvent.
Micellar
catalysis
a
significant
contributor
chemistry
in
water.
It
promotes
pathways
involving
water-sensitive
intermediates
transient
catalytic
species
under
micelles'
shielding
effect
while
also
replacing
costly
ligands
dipolar-aprotic
solvents.
However,
there
lack
of
critical
information
about
micellar
catalysis.
This
includes
why
it
works
better
than
traditional
organic
solvents,
specific
rules
differ
from
those
conventional
catalysis,
how
limitations
can
addressed
future.
Perspective
aims
highlight
current
gaps
our
understanding
provide
an
analysis
designer
surfactants'
origin
essential
components.
will
fundamental
including
aqueous
micelles
simultaneously
perform
multiple
functions
such
as
solvent,
ligand,
reaction
promoter.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(8), P. 5678 - 5692
Published: Feb. 15, 2024
The
rapid
and
controlled
synthesis
of
high-molecular-weight
(HMW)
polysarcosine
(pSar),
a
potential
polyethylene
glycol
(PEG)
alternative,
via
the
ring-opening
polymerization
(ROP)
N-carboxyanhydride
(NCA)
is
rare
challenging.
Here,
we
report
well-controlled
ROP
sarcosine
NCA
(Sar-NCA)
that
catalyzed
by
various
carboxylic
acids,
which
accelerate
rate
up
to
50
times,
enables
robust
pSar
with
an
unprecedented
ultrahigh
molecular
weight
(UHMW)
586
kDa
(DP
∼
8200)
exceptionally
narrow
dispersity
(D̵)
below
1.05.
Mechanistic
experiments
density
functional
theory
calculations
together
elucidate
role
acid
as
bifunctional
catalyst
significantly
facilitates
proton
transfer
processes
avoids
charge
separation
suggest
ring
opening
NCA,
rather
than
decarboxylation,
rate-determining
step.
UHMW
demonstrates
improved
thermal
mechanical
properties
over
low-molecular-weight
counterparts.
This
work
provides
simple
yet
highly
efficient
approach
generates
new
fundamental
understanding
useful
not
only
for
Sar-NCA
but
also
other
NCAs.
Russian Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
92(12), P. RCR5104 - RCR5104
Published: Dec. 1, 2023
After
the
appearance
of
green
chemistry
concept,
which
was
introduced
in
vocabulary
early
1990s,
its
main
statements
have
been
continuously
developed
and
modified.
Currently,
there
are
10–12
cornerstones
that
should
form
basis
for
an
ideal
chemical
process.
This
review
analyzes
accumulated
experience
achievements
towards
design
products
processes
reduce
or
eliminate
use
generation
hazardous
substances.
The
presents
views
leading
Russian
scientists
specializing
various
fields
this
subject,
including
homogeneous
heterogeneous
catalysis,
fine
basic
organic
synthesis,
electrochemistry,
polymer
chemistry,
based
on
bio-renewable
feedstocks
energetic
compounds
materials.
A
new
approach
to
quantitative
evaluation
environmental
friendliness
by
authors
is
described.
<br>
bibliography
includes
1761.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(12), P. 4809 - 4809
Published: June 16, 2023
Many
years
ago,
twelve
principles
were
defined
for
carrying
out
chemical
reactions
and
processes
from
a
green
chemistry
perspective.
It
is
everyone’s
endeavor
to
take
these
points
into
account
as
far
possible
when
developing
new
or
improving
existing
ones.
Especially
in
the
field
of
organic
synthesis,
area
research
has
thus
been
established:
micellar
catalysis.
This
review
article
addresses
question
whether
catalysis
by
applying
reaction
media.
The
shows
that
many
can
be
transferred
an
solvent
medium,
but
surfactant
also
crucial
role
solubilizer.
Thus,
carried
much
more
environmentally
friendly
manner
with
less
risk.
Moreover,
surfactants
are
being
reformulated
their
design,
degradation
add
extra
advantages
match
all
chemistry.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 816 - 830
Published: March 14, 2024
From
the
context
of
sustainability,
contemporary
synthetic
organic
chemistry
practices
require
significant
transformation,
as
indicated
by
various
sustainability
matrices
like
atom
economy,
process
mass
intensity
(PMI),
E-factor,
and
DOZN.
These
factors
have
evidently
unveiled
inherent
inefficiencies
intrinsic
to
conventional
protocols
identified
solvents
principal
causative
agent.
In
response,
utilization
water
a
primary
reaction
medium
for
transformations
has
emerged
an
appealing
alternative.
This
approach
flourished
with
emergence
micellar
catalysis,
where
amphiphilic
molecules
alter
bulk
aqueous
medium's
solvation
properties
promote
desired
chemical
transformation
under
milder
sustainable
conditions.
After
2010,
this
technology
gained
considerable
momentum
established
foundational
framework
performing
reactions
conditions,
consequently
mitigating
dependency
on
hazardous
solvents.
perspective,
recent
advances
in
field
catalysis
will
be
discussed
industrial
applications,
along
future
directions
challenges
associated
regime.
JACS Au,
Journal Year:
2024,
Volume and Issue:
4(2), P. 680 - 689
Published: Feb. 12, 2024
Sustainable
technology
for
constructing
Pd-catalyzed
C–N
bonds
involving
aliphatic
amines
is
reported.
A
catalytic
system
that
relies
on
low
levels
of
recyclable
precious
metal,
a
known
and
commercially
available
ligand,
aqueous
medium
are
combined,
leading
to
newly
developed
procedure.
This
new
can
be
used
in
ocean
water
with
equal
effectiveness.
Applications
highly
challenging
reaction
partners
constituting
late-stage
functionalization
documented,
as
short
but
efficient
synthesis
the
drug
naftopidil.
Comparisons
existing
aminations
highlight
many
advances
being
offered.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2024,
Volume and Issue:
12(5), P. 1997 - 2008
Published: Jan. 22, 2024
A
general
protocol
employing
heterogeneous
catalysis
has
been
developed
that
enables
ppm
of
Pd-catalyzed
C-N
cross-coupling
reactions
under
aqueous
micellar
catalysis.
new
nanoparticle
catalyst
containing
specifically
ligated
Pd,
in
combination
with
nanoreactors
composed
the
designer
surfactant
Savie,
a
biodegradable
amphiphile,
catalyzes
bond
formations
recyclable
water.
variety
coupling
partners,
ranging
from
highly
functionalized
pharmaceutically
relevant
APIs
to
educts
Merck
Informer
Library,
readily
participate
these
environmentally
responsible,
sustainable
reaction
conditions.
Other
key
features
associated
this
report
include
low
levels
residual
Pd
found
products,
recyclability
medium,
use
ocean
water
as
an
alternative
source
options
for
pseudohalides
and
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
28(4), P. 978 - 1002
Published: March 15, 2024
Despite
the
reported
successes
and
advantages
involving
use
of
amphiphilic
surfactants,
most
notably
TPGS-750-M,
to
enable
a
multitude
synthetic
transformations
be
conducted
in
water,
implementation
this
methodology
within
pharmaceutical
industry
has
been
relatively
limited.
In
paper,
we
will
disclose
key
results
learnings
from
multicompany
collaboration
focused
on
reproducibility
study
some
commonly
used
reaction
types
industry,
specifically
amidation,
SNAr,
nitro
reduction,
reductive
amination,
multiple
Pd-catalyzed
water.
The
presentation
not
just
originally
TPGS-750-M
conditions
but
also
under
water-only
control
with
three
different
as
well
both
small
(i.e.,
≤500
mg)
mid
(∼10
g)
scales.
