Structure Tailoring of Hemicyanine Dyes for In Vivo Shortwave Infrared Imaging

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(18), P. 16820 - 16834

Published: Sept. 5, 2024

bioimaging using shortwave infrared (SWIR) (1000-2000 nm) molecular dyes enables deeper penetration and higher contrast compared to visible near-infrared-I (NIR-I, 700-900 dyes. Developing new SWIR molecules is still quite challenging. This study developed

Language: Английский

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Albumin‐Chaperoned Deep‐NIR Triarylmethane Dyes for High‐Contrast In Vivo Imaging and Photothermal Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Fluorophores absorbing/emitting in the deep near-infrared (deep NIR) spectral region, that is, 800 nm and beyond, hold great promise for vivo bioimaging, diagnosis, phototherapy due to deeper tissue penetration. The bottleneck is lack of bright, stable, readily synthesized NIR fluorophores. Here, it reported albumin-chaperon strategy a viable one-for-all address these difficulties. A focused library deep-NIR absorbing dyes (EA5) easily via two-step cascade. They are neither very stable nor bright phosphate buffer propeller-type flexible scaffold. Through screening, EA5_c3 found exhibit high affinity toward bovine serum albumin (BSA). Binding-associated structural rigidification resulted gigantic 26-fold fluorescence enhancement. chaperone also greatly improved stability by shielding bisbenzannulated triarylmethane core from nucleophilic or oxidative species. resulting EA5_c3@BSA exhibits biocompatibility. It offered high-resolution vasculature, lymph systems, tumors, other imaging with its emission. At same time, prominent potential photoacoustic photothermal treatment subcutaneous orthotopic breast tumors. These findings provide insights into robust high-performance fluorophores regions theranostic against aggressive cancers.

Language: Английский

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Long‐Term In Vivo Fluorescence Analyses and Imaging‐Guided Tumor Surgery in the Second Near‐Infrared Window Using a Supramolecular Metallacage

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

ABSTRACT Long‐term in vivo fluorescence analysis is growing into a sparkling frontier gaining deep insights various biological processes. Exploration of such fluorophores with high performance still remains an appealing yet significantly challenging task. In this study, we have elaborately integrated second near‐infrared (NIR‐II) emissive fluorophore the metal Pt self‐assembled prism‐like metallacage M‐DBTP, which enables intravital long‐term tracking through NIR‐II imaging technologies. addition, bioimaging metallacage‐loaded nanoparticles (NPs) indicated extraordinary photographic on mice blood vessels and rapid clearance M‐DBTP NPs from within 7 h. The subsequent transfer to bones retention bone marrow region for up 35 days was revealed by analysis, confirmed distribution metabolism inductively coupled plasma optical emission spectrometer. Moreover, bright them well perform imaging‐guided tumor surgery.

Language: Английский

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Highly Photostable Deep-NIR Chromophore with a Superior Molar Absorptivity for Efficient Photothermal Therapy

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(3), P. 1239 - 1247

Published: Jan. 11, 2024

Organic chromophores, especially those absorbing/emitting in the deep near-infrared region (deep-NIR, i.e., 800 nm and beyond), have prominent potentials photothermal cancer therapy due to tissue penetration good biocompatibility. Although many cyanine/DAD-based agents been successfully used clinical preclinical trials, they are limited poor photostability molar absorptivity. There is still an imperative demand for robust deep-NIR exhibiting high We previously invented a bright push–pull fluorochromic scaffold (EC5) absorbing emitting spectral region. In this work, EC5 was rationally tailored suppress its fluorescence emission promote conversion efficiency. This led design synthesis of EC5PM EC5DP by changing two or four N-alkyl groups headgroups into phenyl groups, respectively. The intensities completely quenched TICT effect associated with N–Ph bonds. particular, maximally absorbs at longer wavelength 879 superior photostability, efficiency 54.8%, extinction coefficient 224,000 M–1 cm–1. Upon encapsulation DSPE-mPEG2000 micelles, phototoxicity showcased 4T1 cells remarkable therapeutic tumors tumor-bearing mouse model. work provides rational strategy ultraphotostable highly organic chromophores therapy.

Language: Английский

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Enhancing the deep-red/near-infrared fluorescence of higher rylene diimides via the chalcogen-annulation strategy

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(4), P. 1324 - 1333

Published: Jan. 5, 2024

Language: Английский

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