Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Cell-surface
receptors
are
vital
for
controlling
numerous
cellular
processes
with
their
dysregulation
being
linked
to
disease
states.
Therefore,
it
is
necessary
develop
tools
study
and
the
signaling
pathways
they
control.
This
Review
broadly
describes
molecular
approaches
that
enable
1)
visualization
of
determine
localization
distribution;
2)
sensing
receptor
activation
permanent
readouts
as
well
in
real
time;
3)
perturbing
activity
mimicking
receptor-controlled
learn
more
about
these
processes.
Together,
have
provided
valuable
insight
into
fundamental
biology
helped
characterize
therapeutics
target
receptors.
Chemical Society Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Light
serves
as
an
excellent
external
stimulus
due
to
its
high
spatial
and
temporal
resolution.
The
use
of
light
regulate
biological
processes
has
evolved
into
a
vibrant
field
over
the
past
decade.
Employing
on
chemical
substances
such
bioactive
molecules
drug
delivery
systems
offers
promising
therapeutic
approach
achieve
precise
control
processes.
In
this
review,
we
provide
overview
advancements
in
optochemical
technologies
for
controlling
(photopharmacology)
(photoresponsive
delivery),
with
emphasis
their
relationship
biomedical
applications.
Gaining
deeper
understanding
underlying
mechanisms
emerging
research
will
facilitate
development
optochemically
controlled
photoresponsive
systems,
further
enhancing
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 479 - 479
Published: March 31, 2024
Over
the
past
few
decades,
photodynamic
therapy
(PDT)
has
evolved
as
a
minimally
invasive
treatment
modality
offering
precise
control
over
cancer
and
various
other
diseases.
To
address
inherent
challenges
associated
with
PDT,
researchers
have
been
exploring
two
promising
avenues:
development
of
intelligent
photosensitizers
activated
through
light-induced
energy
transfers,
charges,
or
electron
disruption
photosensitive
bonds.
Moreover,
there
is
growing
emphasis
on
bioorthogonal
delivery
activation
within
tumors,
enabling
targeted
deployment
these
systems
in
specific
tissues,
thus
achieving
highly
PDT.
This
concise
review
highlights
advancements
made
last
decade
realm
light-activated
photosensitizers,
comparing
their
efficacy
shaping
future
directions
advancement
therapy.
Accounts of Chemical Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
ConspectusLight-driven
polymerizations
and
their
application
in
3D
printing
have
revolutionized
manufacturing
across
diverse
sectors,
from
healthcare
to
fine
arts.
Despite
the
popularized
notion
that
with
"imagination
is
only
limit",
we
others
scientific
community
identified
fundamental
hurdles
restrict
our
capabilities
this
space.
Herein,
describe
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 24, 2025
A
material
that
was
able
to
simultaneously
sense
a
bacterial
presence
and
release
antimicrobial
peptides
(AMP)
on
demand
in
tunable
amount
developed.
Simultaneous
sensing
were
achieved
by
the
combination
of
bacteria-sensing
hydrogel
with
antimicrobial-peptide-carrying
mesoporous
silica
particles
or
coatings.
The
mesopore
diameter
22
nm
functionalized
covalently
grafted
green
light-sensitive
linker,
which
attached.
gelatin-based
hydrogel,
contains
C14R-functionalized
particles,
is
designed
respond
as
it
may
occur,
e.g.,
wound's
microbiological
environment.
In
bacteria
0.1%
trypsin,
protease
enzyme
simulating
presence,
deposited
donut
shape,
undergoes
shape
loss
cleave
cross-linking
bonds
within
hydrogel.
When
observing
after
2
h
readout
infection,
subsequent
irradiation
triggers
adjustable
concentration–time
profiles.
on-demand
are
integrated
into
commercially
available
wound
dressing
fabrics,
demonstrating
an
application
proof-of-concept.
Characterization
using
ATR-IR
spectroscopy,
TGA,
BCA
validates
successful
fabrication
release.
H1.6P
composite
released
agents,
reaching
concentrations
up
298
μg/mL
at
pH
7.4
from
300
μL
sample.
efficacy
C14R
against
E.
coli
BL21(DE3)
illustrated.
Overall,
multifunctionality
this
approach
presents
promising
step
toward
care
thus
for
reducing
side
effects
antibiotic
resistance.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 25, 2025
Cell-surface
receptors
are
vital
for
controlling
numerous
cellular
processes
with
their
dysregulation
being
linked
to
disease
states.
Therefore,
it
is
necessary
develop
tools
study
and
the
signaling
pathways
they
control.
This
Review
broadly
describes
molecular
approaches
that
enable
1)
visualization
of
determine
localization
distribution;
2)
sensing
receptor
activation
permanent
readouts
as
well
in
real
time;
3)
perturbing
activity
mimicking
receptor-controlled
learn
more
about
these
processes.
Together,
have
provided
valuable
insight
into
fundamental
biology
helped
characterize
therapeutics
target
receptors.
