Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(21)
Published: Sept. 14, 2023
Fluorination
reactions
are
important
in
constructing
organofluorine
motifs,
which
contribute
to
favorable
biological
properties
pharmaceuticals
and
agrochemicals.
However,
fluorination
reagents
associated
with
various
problems,
such
as
their
hazardous
nature,
high
exothermicity,
poor
selectivity
scalability.
Continuous
flow
has
emerged
a
transformative
technology
provide
many
advantages
relative
batch
syntheses.
This
review
article
summarizes
recent
continuous
techniques
that
address
the
limitations
challenges
of
reactions.
Approaches
based
on
different
discussed,
including
gas-liquid
reactions,
packed-bed
reactors,
in-line
purifications,
streamlined
multistep
synthesis,
large-scale
well
photoredox-
electrocatalysis.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
11(8)
Published: Oct. 26, 2023
Methane
as
the
main
component
in
natural
gas
is
a
promising
chemical
raw
material
for
synthesizing
value-added
chemicals,
but
its
harsh
conversion
process
often
causes
severe
energy
and
environment
concerns.
Photocatalysis
provides
an
attractive
path
to
active
convert
methane
into
various
products
under
mild
conditions
with
clean
sustainable
solar
energy,
although
many
challenges
remain
at
present.
In
this
review,
recent
advances
photocatalytic
are
systematically
summarized.
As
basis
of
conversion,
activation
first
elucidated
from
structural
molecules.
The
study
committed
categorizing
elucidating
research
progress
laws
intricate
reactions
according
target
products,
including
partial
oxidation,
reforming,
coupling,
combustion,
functionalization.
Advanced
reactor
designs
also
designed
enrich
options
reliability
performance
evaluation.
prospects
discussed,
which
turn
offers
guidelines
methane-conversion-related
photocatalyst
exploration,
reaction
mechanism
investigation,
advanced
photoreactor
design.
The Chemical Record,
Journal Year:
2024,
Volume and Issue:
24(3)
Published: Jan. 22, 2024
Abstract
The
increasing
demand
of
organofluorine
compounds
in
medicine,
agriculture,
and
materials
sciences
makes
sophisticated
methods
for
their
synthesis
ever
more
necessary.
Nowadays,
not
only
the
C−F
bond
formation
but
also
selective
cleavage
readily
available
poly‐
or
perfluorine‐containing
have
become
powerful
tools
effective
compounds.
defluorinative
cross‐coupling
trifluoromethyl
alkenes
with
various
nucleophiles
radical
precursors
an
S
N
2’
manner
is
a
convergent
route
to
access
gem
‐difluoroalkenes,
which
turn
react
via
V‐type
reaction.
If
V
reactions
occur
intramolecularly,
dual
allows
facile
assembly
monofluorinated
cyclic
skeletons
structural
complexity
diversity.
In
this
personal
account,
we
summarized
advances
field
on
basis
coupling
cyclization
partners,
including
binucleophiles,
alkynes,
diradical
bearing
nucleophilic
site.
Accordingly,
annulation
can
be
achieved
by
base‐mediated
sequential
2′/S
reactions,
transition
metal
catalyzed
mediated
photoredox
catalysis,
combination
photocatalytic
context
seminal
works
others
field,
concise
summary
contributions
authors
offered.
ACS Central Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 8, 2024
With
over
10,000
new
reaction
protocols
arising
every
year,
only
a
handful
of
these
procedures
transition
from
academia
to
application.
A
major
reason
for
this
gap
stems
the
lack
comprehensive
knowledge
about
reaction's
scope,
i.e.,
which
substrates
protocol
can
or
cannot
be
applied.
Even
though
chemists
invest
substantial
effort
assess
scope
protocols,
resulting
tables
involve
significant
biases,
reducing
their
expressiveness.
Herein
we
report
standardized
substrate
selection
strategy
designed
mitigate
biases
and
evaluate
applicability,
as
well
limits,
any
chemical
reaction.
Unsupervised
learning
is
utilized
map
space
industrially
relevant
molecules.
Subsequently,
potential
candidates
are
projected
onto
universal
map,
enabling
structurally
diverse
set
with
optimal
relevance
coverage.
By
testing
our
methodology
on
different
reactions,
were
able
demonstrate
its
effectiveness
in
finding
general
reactivity
trends
by
using
few
highly
representative
examples.
The
developed
empowers
showcase
unbiased
applicability
novel
methodologies,
facilitating
practical
applications.
We
hope
that
work
will
trigger
interdisciplinary
discussions
synthetic
chemistry,
leading
improved
data
quality.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 15, 2024
Due
to
the
unique
effect
of
fluorine
atoms,
efficient
construction
high-value
alkyl
fluorides
has
attracted
significant
interest
in
modern
drug
development.
However,
enantioselective
catalytic
strategies
for
assembly
highly
functionalized
chiral
C(sp
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(10)
Published: Jan. 11, 2024
The
synthesis
of
vinyl
fluorides
plays
a
crucial
role
in
various
scientific
disciplines,
including
pharmaceutical
and
materials
sciences.
Herein,
we
present
direct
stereoselective
hydrofluorination
method
for
the
Z
isomers
from
alkynes
containing
unexplored
SF
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(35), P. 19265 - 19273
Published: Aug. 25, 2023
We
report
the
first
one-pot
formal
alkene
carboradiofluorination
reaction
employing
easily
accessible
alkenes
as
both
prosthetic
group
precursors
and
coupling
partners.
The
methodology
features
rapid
sequential
Markovnikov-selective
iodofluorination
photoinduced
Pd(0/I/II)-catalyzed
alkyl
Heck
a
mild
robust
fluorine-18
(18F)
radiochemical
approach
for
positron
emission
tomography
(PET)
imaging
probe
development.
A
new
class
of
groups
PET
synthesis
was
isolated
iodofluorinated
intermediates
in
moderate
to
excellent
yields.
alkenylfluorination
carried
out
produce
over
30
analogues
wide
range
bioactive
molecules.
Further
application
Pd(0/I/II)
manifold
development
illustrated
by
direct
carbo(radio)fluorination
electron-rich
alkenes.
methods
were
successfully
translated
radiolabel
broad
scope
medicinally
relevant
small
molecules
generally
good
conversion.
protocol
further
optimized
accommodate
no-carrier-added
conditions
with
similar
efficiency
future
(pre)clinical
translation.
Moreover,
radiosynthesis
automated
radiochemistry
module
facilitate
its
practical
use
multistep
reactions.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(19), P. 5605 - 5637
Published: Jan. 1, 2024
In
this
review,
we
have
discussed
the
monofluorination
of
natural
products
or
their
derivatives
occurring
via
direct
C–H
functionalization,
late-stage
functionalization
and
functional
group
transformation
from
2011–2023.
