Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy DOI
Futing Wang, Su-Ping Deng, Choong Eui Song

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

In this work, a multifunctional Pd@Au nanoframe hydrogel was designed to detect uric acid (UA) for in situ monitoring of wound infection and enhance healing by chemo-photothermal strategy. acidic conditions, the hydrogels show high peroxidase-like activity catalyzing H2O2 produce reactive oxygen species (ROS) damage RNAs bacteria antibacterial activity. Under Near-infrared (NIR) laser irradiation, exhibit photothermal conversion performance; i.e., color solution varies from deep blue (0 s, 25.4 °C) red (300 50.1 infrared thermography. After loading mupirocin (M), as-obtained M maximum cumulative release rate exceeding 90% mupirocin, as controlled NIR irradiation. antimicrobial experiments vitro, laser-driven ability; 98% Escherichia coli are effectively killed 10 min. coating rabbit wounds with UA sensing patch hydrogels, status can be monitored real time detecting concentration, leading rapid 4 days new synergistic effect This approach successfully confirms closed-loop strategy, real-time efficiently perform therapy, combining functional pharmaceutical antibacterials.

Language: Английский

Conditional PROTAC: Recent Strategies for Modulating Targeted Protein Degradation DOI Creative Commons
Junhyeong Yim, Jun‐Young Park,

G. H. Kim

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(22)

Published: July 12, 2024

Abstract Proteolysis‐targeting chimeras (PROTACs) have emerged as a promising technology for inducing targeted protein degradation by leveraging the intrinsic ubiquitin‐proteasome system (UPS). While potential druggability of PROTACs toward undruggable proteins has accelerated their rapid development and wide‐range applications across diverse disease contexts, off‐tissue effects side‐effects recently received attentions to improve efficacy. To address these issues, spatial or temporal target been spotlighted. In this review, we explore chemical strategies modulating in cell type‐specific (spatio−) time‐specific (temporal−) manner, thereby offering insights expanding PROTAC overcome current limitations strategy.

Language: Английский

Citations

4
Acid-activatable photosensitizers for photodynamic therapy using self-aggregates of chlorophyll‒peptide conjugates DOI Creative Commons

Miyu Nagatani,

Masaru Yoshikawa, Shinya Tsukiji

et al.

Polymer Journal, Journal Year: 2024, Volume and Issue: 57(1), P. 119 - 128

Published: Sept. 19, 2024

Language: Английский

Citations

4
Biomimetic light-harvesting antennas via the self-assembly of chemically programmed chlorophylls DOI
S. Matsubara, Sunao Shoji, Hitoshi Tamiaki

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This feature article describes strategies for constructing supramolecular aggregates of (semi)synthetic dyes, particularly chlorophyll derivatives to mimic the photosynthetic light-harvesting antennas.

Language: Английский

Citations

4
Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes DOI

Shicheng Pei,

Z. L. Liu,

Qishu Jiao

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Efficacious chemotherapy and real-time therapeutic monitoring remain major challenges in cancer treatment. Traditional systems often lack tumor specificity, limiting efficacy, hindering therapy optimization. Moreover, the absence of can lead to missed opportunities increased risks side effects. Herein, we designed a self-reporting ratiometric AIEgen-peptide nanoprobe (TPE-1(Hyd-DOX)-DEVD) for activatable noninvasive imaging outcomes. When doxorubicin (DOX) is selectively activated acidic microenvironment, ensuing caspase-3 cascade triggers morphological transformation that amplifies TPE fluorescence. This enhancement allows TPE/DOX fluorescence ratio serve as an indicator DOX activation providing feedback. Both vitro vivo studies demonstrated TPE-1(Hyd-DOX)-DEVD exhibited impressive suppression efficacy excellent biocompatibility. study highlights strong potential this valuable tool theranostics, offering hope more effective personalized treatment strategies.

Language: Английский

Citations

0
Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy DOI
Futing Wang, Su-Ping Deng, Choong Eui Song

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

In this work, a multifunctional Pd@Au nanoframe hydrogel was designed to detect uric acid (UA) for in situ monitoring of wound infection and enhance healing by chemo-photothermal strategy. acidic conditions, the hydrogels show high peroxidase-like activity catalyzing H2O2 produce reactive oxygen species (ROS) damage RNAs bacteria antibacterial activity. Under Near-infrared (NIR) laser irradiation, exhibit photothermal conversion performance; i.e., color solution varies from deep blue (0 s, 25.4 °C) red (300 50.1 infrared thermography. After loading mupirocin (M), as-obtained M maximum cumulative release rate exceeding 90% mupirocin, as controlled NIR irradiation. antimicrobial experiments vitro, laser-driven ability; 98% Escherichia coli are effectively killed 10 min. coating rabbit wounds with UA sensing patch hydrogels, status can be monitored real time detecting concentration, leading rapid 4 days new synergistic effect This approach successfully confirms closed-loop strategy, real-time efficiently perform therapy, combining functional pharmaceutical antibacterials.

Language: Английский

Citations

0