BioEssays,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
ABSTRACT
Myotonic
dystrophy
type
1
(DM1)
is
considered
a
progeroid
disease
(i.e.,
causing
premature
aging).
This
hypervariable
affects
multiple
systems,
such
as
the
musculoskeletal,
central
nervous,
gastrointestinal,
and
others.
Despite
advances
in
understanding
underlying
pathogenic
mechanism
of
DM1,
numerous
gaps
persist
our
understanding,
hindering
elucidation
heterogeneity
severity
its
symptoms.
Accumulating
evidence
indicates
that
toxic
intracellular
RNA
accumulation
associated
with
DM1
triggers
cellular
senescence.
These
cells
are
state
irreversible
cell
cycle
arrest
secrete
cocktail
cytokines,
referred
to
senescence‐associated
secretory
phenotype
(SASP),
can
have
harmful
effects
on
neighboring
more
broadly.
We
hypothesize
senescence
contributes
pathophysiology
clearance
senescent
promising
therapeutic
approach
for
DM1.
will
discuss
potential
different
senotherapeutic
drugs,
especially
senolytics
eliminate
cells,
senomorphics
reduce
SASP
expression.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Diabetic
foot
ulcers
(DFUs)
are
a
prevalent
and
profoundly
debilitating
complication
that
afflicts
individuals
with
diabetes
mellitus
(DM).
These
associated
substantial
morbidity,
recurrence
rates,
disability,
mortality,
imposing
economic,
psychological,
medical
burdens.
Timely
detection
intervention
can
mitigate
the
morbidity
disparities
linked
to
DFU.
Nevertheless,
current
therapeutic
approaches
for
DFU
continue
grapple
multifaceted
limitations.
A
growing
body
of
evidence
emphasizes
crucial
role
cellular
senescence
in
pathogenesis
chronic
wounds.
Interventions
try
delay
senescence,
eliminate
senescent
cells
(SnCs),
or
suppress
senescence-associated
secretory
phenotype
(SASP)
have
shown
promise
helping
wounds
heal.
In
this
context,
targeting
emerges
as
novel
strategy
comprehensive
review,
we
look
at
pathology
treatment
systematic
way.
We
also
explain
importance
investigating
SnCs
highlight
great
potential
senotherapeutics
target
treatment.
The
development
efficacious
safe
represents
pioneering
approach
aimed
enhancing
quality
life
affected
by
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 116962 - 116962
Published: June 26, 2024
Metabolic
disorders
are
considered
the
hallmarks
of
cancer
and
metabolic
reprogramming
is
emerging
as
a
new
strategy
for
treatment.
Exogenous
endogenous
stressors
can
induce
cellular
senescence;
interactions
between
senescence
systemic
metabolism
dynamic.
Cellular
disrupts
homeostasis
in
various
tissues,
which
further
promotes
senescence,
creating
vicious
cycle
facilitating
tumor
occurrence,
recurrence,
altered
outcomes
anticancer
treatments.
Therefore,
regulation
related
secretory
phenotypes
breakthrough
therapy;
moreover,
proteins
involved
associated
pathways
prospective
therapeutic
targets.
Although
studies
on
association
tumors
have
emerged
recent
years,
elucidation
this
complex
correlation
required
comprehensive
knowledge.
In
paper,
we
review
research
progress
cell
aging
metabolism,
focusing
strategies
targeting
to
modulate
relevant
context
anti-tumor
therapy.
Finally,
discuss
significance
improving
specificity
safety
anti-senescence
drugs,
potential
challenge
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(72), P. 9692 - 9703
Published: Jan. 1, 2024
Supramolecular
chemistry
focuses
on
the
study
of
species
joined
by
non-covalent
interactions,
and
therefore
dynamic
relatively
ill-defined
structures.
Despite
being
a
well-developed
field,
it
has
to
face
important
challenges
when
dealing
with
selective
recognition
biomolecules
in
highly
competitive
biomimetic
media.
However,
supramolecular
interactions
reside
at
core
chemical
biology
systems,
since
many
processes
nature
are
governed
weak,
non-covalent,
strongly
contacts.
Therefore,
there
is
natural
connection
between
these
two
research
fields,
which
not
frequently
related
or
share
interests.
In
this
feature
article,
I
will
highlight
our
most
recent
results
molecular
biologically
relevant
species,
following
different
conceptual
approaches
from
conventional
design
elaborated
receptors
less
popular
combinatorial
methodology.
Selected
illustrative
examples
other
groups
be
also
included.
The
discussion
been
focused
mainly
systems
potential
biomedical
applications.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(9), P. 4498 - 4509
Published: July 29, 2024
Recent
emphasis
on
the
design
of
drug
delivery
systems
typically
involves
effective
transport
a
pharmaceutical
substance
to
disease
site
with
desired
therapeutic
efficacy
and
minimal
cytotoxicity.
Organelle-targeted
peptides
have
become
an
integral
part
designing
important
class
prodrug/prodrug
assemblies
for
new
supramolecular
therapeutics
owing
their
favorable
biocompatibility,
synthetic
ease,
tunability
aggregation
behavior,
functionalization
site-specificity.
However,
it
is
still
limited
due
low
selectivity.
We
designed
folic
acid-functionalized
β-cyclodextrin
(FA-CD)
as
platform
specific
selective
organelle-targeted
(such
microtubule,
lysosome,
mitochondria)
peptide
chemotherapeutics
folate
receptor
(FR)
overexpressing
cancer
cell
lines.
Low
toxicity
was
found
FA-CD
inclusion
complex
in
FR-negative
normal
cells,
but
superior
inhibition
tumor
growth
no
vivo
xenograft
model.
Macromolecules,
Journal Year:
2024,
Volume and Issue:
57(17), P. 8544 - 8553
Published: Aug. 29, 2024
This
work
presents
the
design
and
synthesis
of
a
functional
epoxide
monomer,
2-(benzylthio)ethyl
glycidyl
ether
(BTGE),
serving
as
versatile
building
block
for
development
redox-responsive
polyethers.
It
details
successful
series
poly(2-(benzylthio)ethyl
ether)
(PBTGE)
homopolymers
ABA-type
triblock
copolymers
(i.e.,
PBTGE-b-PEO-b-PBTGE),
achieved
through
controlled
anionic
ring-opening
polymerization
BTGE
using
poly(ethylene
oxide)
(PEO)
macroinitiator.
Comprehensive
characterization
synthesized
monomers
polymers
was
performed
employing
various
analytical
techniques,
such
1H-
13C
NMR,
GPC,
FT-IR
spectroscopy,
MALDI-ToF
mass
spectrometry.
These
demonstrate
unique
behavior,
characterized
by
an
oxidation-induced
transition
from
hydrophobic
to
hydrophilic
states
reductive
deprotection
generate
free
thiol
groups.
Furthermore,
PBTGE-b-PEO-b-PBTGE
have
been
utilized
form
physically
cross-linked
hydrogels
strong
interactions
end
blocks.
Notably,
these
undergo
gel-to-sol
under
oxidative
conditions,
evidenced
rheological
analysis.
study
highlights
potential
monomer
advanced
materials
with
dual
functionalities.
