High-selective dopamine electrochemical sensor based on yolk-shell structural composites derived from Ni-MOF@COFTAPB-DVA

Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112987 - 112987

Published: Feb. 6, 2025

Language: Английский

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Electrochemical Sensing Mechanisms and Interfacial Design Strategies of Mesoporous Nanochannel Membranes in Biosensing Applications

Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

ConspectusPrecise and rapid detection of key biomolecules is crucial for early clinical diagnosis. These critical biomarkers are typically present at low concentrations within complex environments, presenting significant challenges their accurate reliable detection. Nowadays, electrochemical sensors based on nanochannel membranes have attracted attention due to high sensitivity, simplicity, response, label-free point-of-care capabilities. The confined arena provided by the nanochannels target recognition interactions facilitates signal amplification, leading enhanced performance. also can act as filters repel interferents enable in more environments. Thus, considered promising platforms biosensing applications. However, such uncontrollable structures unstable performance some materials limit applications theoretical advancements. To investigate relationship between architecture sensing achieve efficient performance, it essential construct with precise nanostructures possessing stable properties. With development nanomaterials technology, mesoporous robust, controllable, ordered mesostructures, along tunable surface properties tailored ion transport dynamics, emerged candidates achieving Additionally, investigating mechanisms influencing factors will provide valuable insights into optimizing sensor enhancing efficiency reliability technologies. In this Account, we highlight substantial advancements membranes, which mainly research work published our group. first section, explore underlying processes, including solid-liquid interfacial nanoconfinement effects (i.e., electrostatic interactions, hydrophilic/hydrophobic steric hindrance effects). We delve parameters geometry, materials, elements, external related impacts particular, point out that three-dimensional interconnected networks facilitate penetration lead an increased number binding sites, contributing sensitivity. composite or multilevel particularly when integrated stimuli pH, light, heat, introduce unexpected properties, understandings fundamental principles pertinent design intelligent, high-quality nanofluidic devices. Furthermore, conduct analysis integrating various strategies, offers opportunities biomedical monitoring, disease diagnosis, pharmaceutical industry. Finally, describe future directions potential commercial adoption. Nanochannel novel structures, functional porous may new trends applications, self-powered wearable monitoring. believe Account holds implications promoting interdisciplinary endeavors encompassing chemistry science nanotechnology well analysis, biosensing, science.

Language: Английский

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Biosensor Strip for Rapid On‐site Assessment of Levodopa Pharmacokinetics along with Motor Performance in Parkinson's Disease

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(27)

Published: April 29, 2024

Abstract While levodopa (L‐Dopa) is the primary treatment for alleviating Parkinson's disease (PD), its efficacy hindered by challenges such as a short half‐life and inconsistent plasma levels. As PD progresses, rising need increased more frequent L‐Dopa doses coupled with symptom fluctuations dyskinesias underscores urgency improved comprehension of interplay between levels motor symptoms. Addressing this critical need, we present decentralized testing method using disposable biosensor strip universal slope (U‐slope) calibration‐free approach. This enables reliable, rapid, simple, cost‐effective measurements from capillary blood. A pilot study persons demonstrates ability to monitor real‐time pharmacokinetics fingerstick blood after oral L‐Dopa‐Carbidopa (C–Dopa) tablet administration. Correlating scores revealed well‐defined inverse correlation temporal fluctuations. We compared resulting dynamic traditional but clinically impractical high‐performance liquid chromatography technique. By providing timely feedback on proper dosing regimen in rapid fashion, new biosensing platform will facilitate tailored optimal dosing, towards improving management enhancing health‐related quality life.

Language: Английский

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ZnO Nanorods Aligned in a Vertical Configuration for Targeted Electrochemical Detection of Aniline

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 7413 - 7428

Published: Oct. 11, 2024

This study demonstrates the synthesis of 1D surface vertically aligned nanorods ZnO on fluorine-doped tin oxide-coated glass substrate (ZnO-VANRs/FTOs) synthesized via a chemical route for targeted electrochemical sensing aniline. The ZnO-VANRs/FTOs were 1.57 ± 0.03 μm in length with excellent crystallinity and high density (1.52 × 1013 rod no./m2). ZnO-VANRs formation increased roughness by 2.4- 4.7-fold compared to bare FTOs seeded (ZnO-seed/FTOs), respectively. electrodes could increase effective area from 0.154 0.384 cm2 about 86.85% reduction charge transfer resistance FTOs. peak current response (at 0.281 V vs Ag/AgCl) aniline deposition was boosted 81.52% rise temperature 15 45 °C. at involved reversible two-electron diffusion control process heterogeneous reaction rate constant (k0) 1.82 s–1 formal potential (E0) 0.289 Ag/AgCl. electrode showed limits detection 0.193 μM (sensitivity 0.198 μA·μM–1·cm–2) 0.588 0.065 between working ranges 0–20 20–160 μM, fabricated sensor unprecedently selective toward sensing, p-nitroaniline, chlorobenzene, chlorpyrifos, Cu2+, Pb2+, Ni2+, Cd2+, albumin bovine, Escherichia coli, ciprofloxacin not interfere its sensitivity. However, marginally decayed 2.63% up 6th cycle. Moreover, catalyzed spiked environmental matrices, conforming well liquid chromatography.

Language: Английский

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Applications of 2D Nanomaterials in Neural Interface

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8615 - 8615

Published: Aug. 7, 2024

Neural interfaces are crucial conduits between neural tissues and external devices, enabling the recording modulation of activity. However, with increasing demand, simple no longer adequate to meet requirements for precision, functionality, safety. There three main challenges in fabricating advanced interfaces: sensitivity, heat management, biocompatibility. The electrical, chemical, optical properties 2D nanomaterials enhance sensitivity various types interfaces, while newly developed do not exhibit adverse reactions terms management Additionally, can further improve functionality these including magnetic resonance imaging (MRI) compatibility, stretchability, drug delivery. In this review, we examine recent applications focusing on their contributions enhancing performance functionality. Finally, summarize advantages disadvantages nanomaterials, analyze importance biocompatibility testing propose that improving developing composite material structures interface will continue lead forefront field.

Language: Английский

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f-p-d Orbital Hybridization Promotes Hydroxyl Intermediate Adsorption for Electrochemical Biomolecular Oxidation and Identification

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

The rational design of efficient hydroxyl intermediate (*OH) adsorption catalysts for dopamine electrooxidation still faces a major challenge. To address this challenge, CeO2-loaded CuO catalyst inspired by the f-p-d orbital hybridization strategy is designed to achieve *OH and improve oxidation. experimental results theoretical calculations demonstrate that regulates electron distribution at Ce–O–Cu interface, which facilitates transfer optimizes *OH, thereby promoting electrochemical sensor exhibits excellent catalytic activity sensitivity, reaching limit detection 3.22 nM. This work provides promising approach designing highly active electrocatalysts with

Language: Английский

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Chemical Sensors and Biosensors Based on Metal–Organic Frameworks (MOFs)

Chemosensors, Journal Year: 2025, Volume and Issue: 13(2), P. 72 - 72

Published: Feb. 17, 2025

Metal–organic frameworks (MOFs), also referred to as porous coordination polymers [...]

Language: Английский

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Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Acute lung injury (ALI) refers to damage related cells, typically caused by an uncontrollable inflammatory response, and over‐generated reactive oxygen species (ROS). Increasing evidence suggests that reprogramming redox homeostasis holds significant potentials for the clinical treatment of ALI. Herein, simple synthesis ultra‐small Pd loaded covalent organic framework (COF) (TP@Pd) is reported, which, when combined with near infrared (NIR) irradiation, exhibits nanozyme functionalities, including multiple enzyme mimicking activities broad spectrum ROS scavenging, thereby promoting tissue repair ALI immunotherapy. Mechanistically, through therapeutic strategy TP@Pd+NIR, damaged cells tissues are ameliorated decreasing intracellular levels (total ROS, ·OH ·O 2 − ), downregulating cytokines (IL‐6, TNF‐α IL‐1β), upregulating antioxidant factor level (SOD2), inducing macrophage M2 directional polarization (downregulation iNOS CD86, upregulation IL‐10 CD206), activating immunoregulation (CD4 + /CD8 ratio increase), (upregulation HSP70 CD31), suppressing NF‐κB signaling pathway phosphorylated p65 IκBα). Furthermore, following intravenous (IV) injection in rats, TP@Pd accumulated 6 h, indicating promising efficacy via this administration route. Notably, TP@Pd+NIR demonstrated excellent synergistic effects alleviating inflammation storms, reducing diffuse alveolar damage, accelerating repair. Summarily, work has designed a novel enhancement amelioration, which may serve as approach other diseases.

Language: Английский

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Flexible Au–Pt–vertical graphene neural microelectrode for the rapid detection of steady-state and transient dopamine in rats

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 278, P. 117282 - 117282

Published: Feb. 22, 2025

Language: Английский

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Confining Spirocyclic Fluorescein in an Asymmetric Solid‐State Nanochannel: A Simple and Versatile Design Concept for Fabricating Integrated Nanofluidic Diodes with Adjustable Surface Chemistry

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Using small molecules to integrate multifunctional surfaces within a nanopore is an effective way endow smart responsibilities of nanofluidic diodes. However, the complex synthesis hinders their further application in achieving surfaces. Here, simple and versatile design concept reported for fabricating bioinspired integrated diodes with adjustable surface chemistry by confining spirocyclic fluorescein derivative, 6‐aminofluorescein (6‐AF), asymmetric track‐etched nanopore. The pH‐dependent open‐close lactone ring 6‐AF allows facile fabrication pH‐gated diode, confirmed finite element simulations. This diode also shows high specificity sensing 3‐nitropropionic acid (3‐NPA), indicating its potential applications food safety. Moreover, three functional are successfully constructed via regioselective Vilsmeier reaction between N‐methylformanilide, electrophilic addition propargyl bromide, highly controllable reduction process NaBH 4 /I 2 . combination nanopores not only expands traditional fluorescent realm electrochemistry but offers valuable insights achievement novel fluorescence‐electrochemical coupling detection methods. Besides, introduction serves as inspiration source explore new concepts devices.

Language: Английский

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