Directed Cell Growth of C2C12 Cells on ECM Free Bioprinted Nano/Micro Scaffolds

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Skeletal muscle cell growth impairment can result in severe health issues, such as reduced mobility, metabolic problems, and cardiovascular which significantly impact an individual's overall lifestyle. To address this issue, it is essential to adopt a multi-faceted approach. Conventional 2D culture methods fail replicate the critical features of vivo micro/nanoarchitecture, crucial for skeletal cells. In study, directed mouse myoblasts (C2C12) cells on ECM-free biocompatible scaffolds demonstrated fabricated using two-photon lithography (TPL). These are 3D have nano/micro-features derived from chitosan-based carbon quantum dots (Ch-CQDs). Ch-CQDs act initiators TPL also provide with adequate mechanical strength specific binding sites. support cellular adhesion without need ECM coating. The nano/micro mimic microenvironment, enabling surfaces. tunable ranging 0.09 0.75 GPa. By Ch-CQDs, created that promote alignment, growth.

Language: Английский

Photon-driven radical hydro-phosphoniumylation of unactivated olefins

Chem Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 101219 - 101219

Published: Dec. 1, 2024

Language: Английский