Visible Light‐Induced Radical Tandem Cyclization of o‐Isocyanodiaryl Amines with Arylthiodifluoroalkyl 2‐Pyridyl Sulfones or Difluormethyl‐ Bromides

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(41)

Published: Aug. 6, 2024

Abstract A visible‐light‐induced photoredox‐catalyzed radical tandem cyclization of o ‐isocyanodiaryl amines with arylthiodifluoroalkyl 2‐pyridyl sulfones or difluormethyl bromides has been realized for the first time. The reaction works a broad range substrates and provides simple efficient method synthesis 11‐difluoromethyl‐substituted dibenzodiazepines from easily available starting materials in very mild conditions.

Language: Английский

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Palladium-catalyzed difluorocarbene transfer enables access to enantioenriched chiral spirooxindoles

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 1, 2024

Language: Английский

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Some fluorine-containing and sulfur-containing functional new reagents

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(21), P. 1785 - 1807

Published: Aug. 17, 2024

The research and development of new reagents play a crucial role for organic synthesis. In recent years, numerous with universal applicability have been reported. Recent progress selected fluorine-containing sulfur-containing difluoromethylation, trifluoromethylation thiotrifluoromethylation are summarized. Additionally, some provided, as reagent, Na2S2O4-t-butylhydroperoxide (TBHP) is reagent selective oxidation aromatic alcohols to aldehydes.

Language: Английский

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Facile double O-difluoromethylations of diphenols with TMSCF2Br

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 152, P. 155335 - 155335

Published: Oct. 18, 2024

Language: Английский

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