Fluoroalcohols for chemical modification of biomolecules DOI Creative Commons
Md. Nuruzzaman, Zeinab M. Nizam, Jun Ohata

et al.

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: 11, P. 100088 - 100088

Published: Aug. 1, 2024

While their broad utility in various chemistry fields were well recognized for decades, fluoroalcohols have recently emerged as a unique solvent system bioconjugation development. This review describes examples and roles of such trifluoroethanol (TFE) hexafluoroisopropanol (HFIP) chemical modification biomolecules polypeptides, nucleic acids, saccharides. Many processes facilitated by notable functions those proton shuttle, reversible adduct formation with reactive species, compatibility electrochemistry/photochemistry. The usefulness the fluoroalcohol solvents can be even promoted its combination different reaction enhancement protein stabilization. collection transformations this is an indication rapid growth solvent-assisted field.

Language: Английский

Fluoroalcohols for chemical modification of biomolecules DOI Creative Commons
Md. Nuruzzaman, Zeinab M. Nizam, Jun Ohata

et al.

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: 11, P. 100088 - 100088

Published: Aug. 1, 2024

While their broad utility in various chemistry fields were well recognized for decades, fluoroalcohols have recently emerged as a unique solvent system bioconjugation development. This review describes examples and roles of such trifluoroethanol (TFE) hexafluoroisopropanol (HFIP) chemical modification biomolecules polypeptides, nucleic acids, saccharides. Many processes facilitated by notable functions those proton shuttle, reversible adduct formation with reactive species, compatibility electrochemistry/photochemistry. The usefulness the fluoroalcohol solvents can be even promoted its combination different reaction enhancement protein stabilization. collection transformations this is an indication rapid growth solvent-assisted field.

Language: Английский

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