Click Reaction-Based Afterglow Signal Activation and Nanoparticle Size Tunability for Precise Lung Cancer Imaging and Therapy

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Language: Английский

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A Kidney-Targeted Rapid Photoacoustic Probe Activated by Sulfur Dioxide for 3D Visual Diagnosis of Iodinated Contrast-Induced Acute Kidney Injury

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Sulfur dioxide (SO2) dysmetabolism is closely associated with various diseases such as acute kidney injury (AKI). Nevertheless, the relationship between SO2 levels and iodinated contrast-induced AKI remains largely unclear. Therefore, accurate imaging of level fluctuations in vivo therefore critically important. However, no photoacoustic (PA) method currently available for detection SO2. To address this gap, we designed synthesized a PA probe toward SO2, namely, Rho-QL, first time performed situ deep tissues vivo. A novel was accordingly developed 3D visual diagnosis based on high spatial resolution. Rho-QL exhibited response 5 s displayed remarkable turn-on absorption changes at 700 nm, making it suitable detecting via imaging. Moreover, an excellent targeting ability to kidney, thereby facilitating kidney. Notably, through real-time imaging, successfully applied visualization detailed distribution resolution revealed increase during process. Based current findings, expected become powerful tool study AKI-related diseases.

Language: Английский

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Medical imaging-based companion diagnostics for solid tumors

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1), P. 100009 - 100009

Published: May 11, 2024

Heterogeneity within the solid tumor microenvironment contributes to a poor prognosis and limited therapeutic responses. Companion diagnostics (CDx), clinical technique that gives doctors vital biomarker information enhance patient outcomes through matching specific treatments patients, is becoming more important. However, most current US Food Drug Administration (FDA)-approved CDx tests have difficulty dynamically reflecting variations in biomarkers because they are used vitro ex vivo. Consequently, new medical imaging-based been widely detect interpatient intrapatient heterogeneity assess intratumoral distribution of variables. They provide stratification for targeted therapies differentiation populations benefit from alternative treatments. This review provides an overview recent advances tumors summarizes various utilized CDx. We believe this offers additional details directions promoting development.

Language: Английский

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Polarity Sensitive and H₂O₂/Lipid Droplets Sequence‐Activated Asymmetric Cyanine Probe Achieves Multi‐marker Imaging of Atherosclerosis

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Comprehensive Summary Atherosclerosis is a lipoprotein‐driven disease. In‐depth understanding of pathology and accurate identification are particularly important in clinical assessment treatment due to the irreversibility atherosclerotic plaque formation. not only accompanied by lipid droplets accumulation but also closely related inflammation, which excessive reactive oxygen species (ROS) changes microenvironment. However, there still lack simple rapid detection platform simultaneously evaluate multiple indicators atherosclerosis channels. In this study, we propose multicolor imaging probe Cy7P‐B for polarity, H 2 O plaques vivo . sensitive environmental polarity can monitor near‐infrared ratio. Moreover, has /lipid dual‐analyte sequential activation characteristics. Based on multifunctional properties , classical biomarkers plaque, up‐regulation oxidative stress effectively detected plaques, more importantly, change aortic was first time. This work provides general molecular design approach multi‐species AS, helpful effective cardiovascular disease stewardship.

Language: Английский

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Electrospinning and electrospun nanofibers: From academic research to industrial production

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101494 - 101494

Published: April 1, 2025

Language: Английский

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