Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
The
uranyl
ion
(UO22+)
is
the
most
stable
form
of
uranium,
which
exhibits
high
toxicity
and
bioavailability
posing
a
severe
risk
to
human
health.
construction
ultrasensitive,
reliable,
robust
sensing
techniques
for
UO22+
detection
in
water
soil
samples
remains
challenge.
Herein,
DNA
network
biosensor
was
fabricated
using
DNAzyme
as
heavy
metal
recognition
element
double-loop
hairpin
probes
assembly
materials.
UO22+-activated
specific
cleavage
will
liberate
triggered
fragment,
can
be
utilized
launch
probe
among
Hab,
Hbc,
Hca.
Through
multiple
cyclic
cross-hybridization
reactions,
hexagonal
duplex
nanostructures
(n[Hab•Hbc•Hca])
were
formed.
This
system
generates
fluorescence
response
monitoring.
with
limit
2
pM.
also
displays
an
excellent
selectivity
robustness,
enabling
work
even
complex
accuracy
reliability.
With
advantages
enzyme-free
operation,
outstanding
specificity,
sensitivity,
our
proposed
provides
simple,
method
trace
levels
environmental
samples.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(36)
Published: June 14, 2024
Abstract
Mitochondria,
one
of
the
most
important
organelles,
represent
a
crucial
subcellular
target
for
fundamental
research
and
biomedical
applications.
Despite
significant
advances
in
design
DNA
nanotechnologies
variety
bio‐applications,
dearth
strategies
that
enable
mitochondria
targeting
molecular
imaging
therapy
remains
an
outstanding
challenge
this
field.
In
Minireview,
we
summarize
recent
progresses
on
emerging
application
nanotechnology
mitochondria‐targeted
tumor
treatment.
We
first
highlight
engineering
mitochondria‐localized
nanosensors
situ
detection
diverse
key
molecules
are
essential
to
maintain
mitochondrial
functions,
including
microRNA,
enzymes,
small
molecules,
metal
ions.
Then,
compile
developments
anti‐tumor
therapy,
modularly
designed
nanodevices
delivery
therapeutic
agents,
programmed
assembly
interference.
will
place
emphasis
clarification
chemical
principles
how
nanobiotechnology
can
be
various
Finally,
remaining
challenges
future
directions
field
discussed,
hoping
inspire
further
development
advanced
toolkits
both
academic
clinical
regarding
mitochondria.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(44), P. 30224 - 30246
Published: Oct. 23, 2024
Each
organelle
referring
to
a
complex
multiorder
architecture
executes
respective
biological
processes
via
its
distinct
spatial
organization
and
internal
microenvironment.
As
the
assembly
of
biomolecules
is
structural
basis
living
cells,
creating
synthetic
nanoassemblies
with
specific
physicochemical
morphological
properties
in
cells
interfere
or
couple
natural
architectures
has
attracted
great
attention
precision
therapeutics
cancers.
In
this
review,
we
give
an
overview
latest
advances
for
precise
regulation,
including
formation
mechanisms,
triggering
strategies,
biomedical
applications
therapeutics.
We
summarize
emerging
material
systems,
polymers,
peptides,
deoxyribonucleic
acids
(DNAs),
their
intermolecular
interactions
intercellular
nanoassemblies,
highlight
design
principles
constructing
precursors
that
assemble
into
targeting
organelles
cellular
environment.
further
showcase
developed
intracellular
mitochondria,
endoplasmic
reticulum,
lysosome,
Golgi
apparatus,
nucleus
describe
underlying
mechanisms
regulation
cancer.
Last,
essential
challenges
field
prospects
future
are
discussed.
This
review
should
facilitate
rational
organelle-targeting
comprehensive
recognition
by
materials
contribute
deep
understanding
application
Fundamental Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
self-assembly
of
artificial
structures
within
living
cells
provides
valuable
insights
into
cellular
mechanisms
and
control
functions,
thereby
contributing
to
advancements
in
biomedicine
synthetic
biology.
To
precisely
the
intracellular
assembly
process,
exogenous
active
substances
have
been
introduced,
which
respond
natural
environments.
Deoxyribonucleic
acid
(DNA)
is
a
versatile
biological
macromolecule
that
has
great
potential
as
building
block
construct
biomaterials
addition
genetic
material.
Through
rational
sequence
design,
DNA
molecules
can
form
variety
functional
structures,
enabling
precise
efficient
assembly.
These
properties
greatly
enrich
forms
expand
applications
molecules.
In
this
review,
we
summarize
controlled
DNA-based
materials
under
various
stimulating
conditions.
We
highlight
three
main
materials.
First,
interact
with
alter
environment
influence
cell
behavior
fate.
Second,
assemblies
affect
subcellular
interfere
functions.
Third,
modules
enable
diagnosis
treatment
cancers
by
recognizing
for
tumor
detection,
imaging,
drug
delivery.
From
effects,
review
comprehensively
summarizes
dynamic
envisages
challenges
future
research
prospects
field.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 6, 2024
The
uranyl
ion
(UO22+)
is
the
most
stable
form
of
uranium,
which
exhibits
high
toxicity
and
bioavailability
posing
a
severe
risk
to
human
health.
construction
ultrasensitive,
reliable,
robust
sensing
techniques
for
UO22+
detection
in
water
soil
samples
remains
challenge.
Herein,
DNA
network
biosensor
was
fabricated
using
DNAzyme
as
heavy
metal
recognition
element
double-loop
hairpin
probes
assembly
materials.
UO22+-activated
specific
cleavage
will
liberate
triggered
fragment,
can
be
utilized
launch
probe
among
Hab,
Hbc,
Hca.
Through
multiple
cyclic
cross-hybridization
reactions,
hexagonal
duplex
nanostructures
(n[Hab•Hbc•Hca])
were
formed.
This
system
generates
fluorescence
response
monitoring.
with
limit
2
pM.
also
displays
an
excellent
selectivity
robustness,
enabling
work
even
complex
accuracy
reliability.
With
advantages
enzyme-free
operation,
outstanding
specificity,
sensitivity,
our
proposed
provides
simple,
method
trace
levels
environmental
samples.
