Advances and prospects on production of lactulose and epilactose by cellobiose 2-epimerases: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141283 - 141283

Published: Feb. 19, 2025

Language: Английский

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Precise Synthesis of Complex Si–Si Molecular Frameworks

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: 147(4), P. 2938 - 2959

Published: Jan. 16, 2025

In this Perspective, we highlight the emergence of target-oriented syntheses complex molecules composed Si-Si (oligosilanes) rather than C-C bonds. Saturated oligosilanes structurally resemble alkanes with respect to a tetrahedral geometry, preference for staggered conformation in linear chains, ability form stable small rings, and stereochemistry at asymmetrically functionalized Si centers. There are also critical differences, example, differences multiple bonding penta- hexacoordinated structures, that mean chemical reactivity and, particular, rules stereoselective synthesis do not cleanly translate from carbon silicon. This Perspective will discuss recent achievements precise, controlled comprised mainly bonds mechanistic insights enabling increased molecular complexity. New tools, such as electrochemical catalytic reactions, be discussed well problem controlling relative configuration containing stereogenic-at-silicon These synthetic facilitate discovery new properties, including insight into light absorption, conformation, mechanical properties.

Language: Английский

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Site-selective dimethylation of flavonoids using fusion flavonoid O-methyltransferases

Applied Biological Chemistry, Journal Year: 2025, Volume and Issue: 68(1)

Published: Feb. 8, 2025

Language: Английский

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Bidirectional chemical intelligent net: A unified deep learning–based framework for predicting chemical reaction

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110968 - 110968

Published: Feb. 1, 2025

Language: Английский

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Trypsin-catalyzed asymmetric aldol reactions of isatins with cyclic ketones and the mechanistic insights on activity differences at theoretical level

Journal of Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Recent progress of advanced Nanozymes for targeted oncotherapy and synergistic immunotherapy

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 536, P. 216674 - 216674

Published: April 5, 2025

Language: Английский

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Mechanochemical Radical Transformations in Organic Synthesis

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Organic synthesis has historically relied on solution‐phase, polar transformations to forge new bonds. However, this paradigm is evolving, propelled by the rapid evolution of radical chemistry. Additionally, organic witnessing a simultaneous resurgence in mechanochemistry, formation bonds solid‐state, further contributing shift status quo. The aforementioned advances chemistry have predominantly occurred solution phase, while majority mechanochemical feature transformations. Herein, we discuss rapidly advancing area synthesis: reactions. Solid‐state reactions offer improved green metrics, better reaction outcomes, and access intermediates products that are difficult or impossible reach solution. This review explores these context small molecule synthesis, from early findings current state‐of‐the‐art, underscoring pivotal role solid‐state likely play sustainable chemical synthesis.

Language: Английский

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Exploiting Archaeal/Thermostable Enzymes in Synthetic Chemistry: Back to the Future?

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(21)

Published: July 8, 2024

Abstract Billions of years evolution have led to the selection (hyper)thermophiles capable flourishing at elevated temperatures. The corresponding native (hyper)thermophilic enzymes retain their tertiary and quaternary structures near‐boiling water temperatures naturally catalytically competent conformational dynamics under these conditions. And yet, while hyper/thermophilic offer special opportunities in biocatalysis hybrid bio/chemocatalytic approaches modern synthesis both academia industry, remain underexplored biocatalysis. Among strategic advantages that can be leveraged running biocatalytic transformations higher are included more favorable kinetics, removal volatile byproducts drive reactions forward, improved substrate solubility product separation, accelerated stereodynamics for dynamic kinetic resolutions. These topics discussed illustrated with contemporary examples note, sections organized by stratagem. Finally, reader is alerted particular archaeal proven useful non‐natural synthetic chemistry ventures, same time referred a rich area archaea whose genomes been sequenced but enzymatic activities interest not yet mined. Though hyperthermophilic among most ancient organisms, may hold key many future innovations chemistry–perhaps we really do need go ‘back future’.

Language: Английский

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Bidirectional Chemical Intelligent Net: A unified deep learning–based framework for predicting chemical reactions

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Chemical reactions, which transform one set of substances to another, drive research in chemistry and biology. Recently, computer-aided chemical reaction prediction has spurred rapidly growing interest, various deep learning–based algorithms have been proposed. However, current efforts primarily focus on developing models that support specific applications, with less emphasis building unified frameworks predict reactions. Here, we developed Bidirectional Intelligent Net (BiCINet), a framework based Auto-Regressive Transformers (BARTs), for predicting reactions tasks, including the bidirectional organic synthesis enzyme-mediated This versatile was trained using general achieved top-1 forward backward accuracies 80.6% 48.6%, respectively, public benchmark dataset USPTO_50K. By multitask transfer learning integrating task prompts into model, BiCINet enables retrosynthetic planning metabolic small molecules, as well analysis enzyme-catalyzed product natural products. These results demonstrate superiority our multifunctional comprehensively understanding

Language: Английский

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Overcoming Bottlenecks towards Complete Biocatalytic Conversions and Complete Product Recovery

Reaction Chemistry & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Sustainable processes by completing biocatalytic conversions and recovering products completely.

Language: Английский

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