ChemCatChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 27, 2024
Abstract
Elevated
levels
of
reactive
oxygen
species
(ROS)
are
a
hallmark
varieties
diseases
such
as
cancer,
inflammation,
and
neurodegenerative
disorders.
Inspired
by
the
discrepancy
ROS
concentrations
between
pathological
tissues
normal
counterparts,
an
increasing
number
ROS‐responsive
theragnostic
prodrugs
developed
in
past
years,
with
particularly
high
proportions
organoboron‐based
that
can
respond
to
H
2
O
.
Unfortunately,
studies
have
demonstrated
intrinsic
(H
)
most
tissue
only
slightly
higher
than
not
adequate
activate
organoboron
prodrugs;
contrast,
several
compounds
been
clinically
approved
which
boronic
acid
acts
electrophilic
warhead.
To
this
end,
developing
more
robust
universal
approaches
for
acid‐prodrug
activation
becomes
highly
attractive.
In
context,
we
discuss
recently
reported
strategies
boron‐caged
particular
focus
on
their
design
principles
mechanisms.
The
perspectives
future
directions
important
research
area
discussed
well.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
The
cell
surface
proteome,
or
surfaceome,
is
the
hub
for
cells
to
interact
and
communicate
with
outside
world.
Many
disease-associated
changes
are
hard-wired
within
yet
approved
drugs
target
less
than
50
proteins.
In
past
decade,
proteomics
community
has
made
significant
strides
in
developing
new
technologies
tailored
studying
surfaceome
all
its
complexity.
this
review,
we
first
dive
into
unique
characteristics
functions
of
emphasizing
necessity
specialized
labeling,
enrichment,
proteomic
approaches.
An
overview
surfaceomics
methods
provided,
detailing
techniques
measure
protein
expression
how
leads
novel
discovery.
Next,
highlight
advances
proximity
labeling
(PLP),
showcasing
various
enzymatic
photoaffinity
can
map
protein-protein
interactions
membrane
complexes
on
surface.
We
then
review
role
extracellular
post-translational
modifications,
focusing
glycosylation,
proteolytic
remodeling,
secretome.
Finally,
discuss
identifying
tumor-specific
peptide
MHC
they
have
shaped
therapeutic
development.
This
emerging
field
neo-protein
epitopes
constantly
evolving,
where
targets
identified
at
proteome
level
encompass
defined
PTMs,
complexes,
dysregulated
cellular
tissue
locations.
Given
functional
importance
biology
therapy,
view
as
a
critical
piece
quest
neo-epitope
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 7, 2025
Herein
we
describe
a
comprehensive
study
of
ligand
effects
on
optoelectronic
properties
series
Ir(III)
catalysts
which
undergo
formally
spin-forbidden
excitation
using
low-energy
light.
We
demonstrate
that
electronic
and
steric
tuning
several
variables
can
be
explained
by
their
impact
the
HOMO
LUMO
energies
complex.
Density
functional
theory
calculations
catalysts'
adiabatic
triplet
agree
with
experimental
results
to
within
0.05
eV
average.
As
many
these
subtle
are
independent
each
other,
merger
them
in
single
complex
tends
have
an
additive
effect
thus
succeeded
developing
family
highly
oxidizing
iridium
photocatalysts
operate
excitation.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Fluorine
and
nitrogen
form
a
successful
partnership
in
organic
synthesis,
medicinal
chemistry,
material
sciences.
Although
fluorine-nitrogen
chemistry
has
long
rich
history,
this
field
received
increasing
interest
made
remarkable
progress
over
the
past
two
decades,
driven
by
recent
advancements
transition
metal
organocatalysis
photochemistry.
This
review,
emphasizing
contributions
from
2015
to
2023,
aims
update
state
of
art
synthesis
applications
nitrogen-based
organofluorine
functional
molecules
chemistry.
In
dedicated
sections,
we
first
focus
on
fluorine-containing
reagents
organized
according
type
groups
attached
nitrogen,
including
N-F,
N-RF,
N-SRF,
N-ORF.
review
also
covers
nitrogen-linked
building
blocks,
catalysts,
pharmaceuticals,
agrochemicals,
underlining
these
components'
broad
applicability
growing
importance
modern
Journal of the American Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Selective
inhibition
of
TrxR1
over
TrxR2
is
a
highly
sought-after
goal,
because
the
two
enzymes
play
distinct
roles
in
cancer
progression.
However,
achieving
targeted
challenging
due
to
their
high
homology
and
identical
active
site
sequence.
Herein
we
report
new
subcellular
photocatalysis
approach
for
by
controllably
activating
organogold(I)
prodrugs
within
cytosol,
exclusive
location
TrxR1.
The
NHC-Au(I)-alkynyl
complexes
are
stable
evenly
distributed
cell;
they
can
meanwhile
be
efficiently
transformed
into
NHC-Au(I)-L
species
(L
=
labile
ligands)
via
radical
mechanism
photocatalysts
released
cytosol
(from
endosome/lysosome)
upon
light
irradiation,
leading
selective
without
affecting
TrxR2.
This
results
strong
cytotoxicity
cells
with
much
higher
selectivity
than
auranofin,
pan
TrxR
inhibitor
that
cannot
discriminate
TrxR1/2,
along
potent
antitumor
activities
multiple
zebrafish
mouse
models.
prodrug
activation
may
thus
suggest
novel
precision
targeting
using
remarkable
spatial
control
photocatalysis.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(27)
Published: May 22, 2024
Abstract
Fluorinated
organic
compounds
represent
an
important
and
growing
family
of
active
ingredients
in
various
fields,
including
material
science,
pharmaceutical
chemistry
biological
science.
Developing
efficient
synthetic
methods
toward
fluorinated
have
attracted
much
attention.
In
recent
years,
transition‐metal
catalyzed
reaction
trifluoro
diazo
were
a
powerful
convenient
approach
to
afford
trifluoromethyl‐
difluoromethyl‐substituted
value.
this
review,
the
progress
on
transition‐metal‐catalyzed
reactions
involving
their
surrogates
via
trifluoromethylated
carbene
complex
is
described
sequence
2,2,2‐trifluorodiazoethane
as
precursor,
ethyl
3‐trifluoro‐2‐diazo‐propionate
trifluoroethylamine
hydrochloride
or
amines
CF
3
CHN
2
surrogate
well
aldehydes/ketones
N‐sulfonylhydrazones
surrogate.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(37), P. 7976 - 7980
Published: Sept. 6, 2024
The
use
of
an
earth-abundant
and
inexpensive
iron
complex
as
a
catalyst,
coupled
with
near-infrared
(NIR)
light
the
energy
source,
for
radical
reactions
alkyl
halides
has
been
far
less
developed.
In
this
study,
we
report
NIR
light-mediated
iron(I)
dimer-catalyzed
cascade
fluoroalkyl
bromides
synthesis
ring-fused
quinazolinones
bearing
difluoromethyl
group.
process,
3-bromo-1,10-phenanthroline
ligand
facilitates
reactivity
[CpFe(CO)
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 23, 2024
Abstract
A
novel
bifunctional
photocatalyst
combining
an
aza-BODIPY
and
a
chiral
oxazoline
has
been
developed.
This
enables
the
asymmetric
hydroxylation
of
β‑ketoesters
under
oxygen
atmosphere
irradiation
with
18-W
red
LEDs.
procedure
offers
convenient
potentially
general
approach
to
obtain
enantioenriched
α-hydroxy-β-dicarbonyl
products.
The
results
reported
in
this
manuscript
demonstrate
promise
new
organic
design
will
help
expand
application
BODIPY-based
photocatalysts.
