GalNAc modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma DOI
Yanhua Li,

Yingying Song,

Jiaqi Yin

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(78), P. 10882 - 10885

Published: Jan. 1, 2024

GalNAc-modified ferrous sulfide nanoparticles have been developed to conduct chemodynamic and gas therapy for fighting against orthotopic hepatocellular carcinoma. This nanomedicine owns good liver targeting ability, which takes full advantage of the tumor microenvironment ensure effect improve safety.

Language: Английский

Polydopamine Surface Engineering of Iron Single-Atom Nanozyme: a Novel Strategy for Doxorubicin Immobilization, Tumor Microenvironment Remodeling and Synergistic Multimodel Therapy DOI Creative Commons
Meiling Liu, Jing Liu, Minjuan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract The variation in tumor microenvironment, specifically the levels of cellular H2O2/O2/GSH, plays a crucial role effectiveness cancer therapy nanozyme-drug systems. In this study, bioinspired polydopamine was utilized to surface engineer rhombic dodecahedron morphology iron-based SANzyme (Fe SANzyme), which exhibited multiple mimetic activities including oxidase (OXD)-like, peroxidase (POD)-like, catalase (CAT)-like, and glutathione (GPx)-like activities. Fe SAN-PDA intricately designed as nanoplatform for drug immobilization, remodeling microenvironment (TME) enabling synergistic multimodal therapy. presence abundant quinone structures on PDA facilitated creation conductive immobilization doxorubicin (DOX) through Michael addition/Schiff base reaction. SAN-PDA@DOX can catalyze high level H2O2 TME produce oxygen alleviate hypoxia, convert produced toxic ·OH, deplete intracellular glutathione. Coating with hyaluronic acid (HA) enhanced biocompatibility targeting ability composite. exceptional photothermal performance SAN-PDA@DOX@HA, combined nanozyme catalysis, resulted sustained chemodynamic/photothermal/ chemotherapy is achieved mouse mammary carcinoma model. This research highlights therapeutic effects resulting from combination multi-enzymatic SAN multifunctional PDA, offering novel strategy

Language: Английский

Citations

0
An electrically activable nanochip to intensify gas-ionic-immunotherapy DOI
Gang Wang, Jingrui Li,

Shumin Sun

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Ultralow Ru doping MOF-based sensing probe with interface engineering regulation-triggered detection of hydrogen sulfide and cystathionine γ-lyase activity DOI
Hongyuan Shang, Aiping Zhang, Xiaofei Zhang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 426, P. 136978 - 136978

Published: Dec. 5, 2024

Language: Английский

Citations

0
GalNAc modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma DOI
Yanhua Li,

Yingying Song,

Jiaqi Yin

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: 60(78), P. 10882 - 10885

Published: Jan. 1, 2024

GalNAc-modified ferrous sulfide nanoparticles have been developed to conduct chemodynamic and gas therapy for fighting against orthotopic hepatocellular carcinoma. This nanomedicine owns good liver targeting ability, which takes full advantage of the tumor microenvironment ensure effect improve safety.

Language: Английский

Citations

0