Metal–Organic Frameworks for Sustainable Crop Disease Management: Current Applications, Mechanistic Insights, and Future Challenges

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(42), P. 22985 - 23007

Published: Oct. 9, 2024

Efficient management of crop diseases and yield enhancement are essential for addressing the increasing food demands due to global population growth. Metal-organic frameworks (MOFs), which have rapidly evolved throughout 21st century, notable their vast surface area, porosity, adaptability, establishing them as highly effective vehicles controlled drug delivery. This review methodically categorizes common MOFs employed in disease details effectiveness against various pathogens. Additionally, by critically evaluating existing research, it outlines strategic approaches design drug-delivery explains mechanisms through enhance resistance. Finally, this paper identifies current challenges MOF research suggests directions future research. Through in-depth review, seeks enrich understanding applications offers valuable insights researchers practitioners.

Language: Английский

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Glutathione‐Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 13, 2024

Abstract Radiotherapy plays a crucial role in the treatment of advanced breast cancer, but increased antioxidant system, especially rise glutathione (GSH), presents significant obstacle to its effectiveness. To address this challenge, versatile GSH‐depleted photodynamic nanoadjuvant is developed augment efficacy radiotherapy for cancer treatment. This operates within tumor microenvironment effectively deplete intracellular GSH through sequence cascaded processes, including exhaustion, biosynthetic inhibition, and oxidation. leads notable accumulation lipid peroxides (LPO) subsequent suppression peroxidase 4 (GPX4) activity. Consequently, combined depletion induced by markedly promotes nonferrous ferroptosis, thereby contributing augmentation antitumor efficiency during cancer. work an innovative approach designing synthesizing biocompatible nanoadjuvants with goal improving prospective clinical scenarios.

Language: Английский

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PEGylated BODIPY Photosensitizer for Type I Dominant Photodynamic Therapy and Afterglow Imaging

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(45), P. 61739 - 61750

Published: Oct. 30, 2024

Type I photodynamic therapy (PDT) exhibits outstanding therapeutic effects in hypoxic environments tumors, but the design of type photosensitizers (PSs), especially those with simple structures dramatic properties, remains a challenge. Herein, we report strategy for developing PSs one molecule afterglow luminescence. As proof concept, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) PS (BIP) bearing water-soluble poly(ethylene glycol) (mPEG550) chains is synthesized, and BIP can self-assemble into nanoparticles (BIPNs). Interestingly, BIPNs exhibit an O2•--triggered luminescence, which scarce, BODIPY derivatives. demonstrate dominant PDT at ultralow dose under both normoxic environments, significantly inhibit tumor growth irradiation. This work highlights high-performance luminescence excellent effects, underscoring significant potential versatile clinical theranostics.

Language: Английский

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Deeply Implantable, Shape‐Morphing, 3D MicroLEDs for Pancreatic Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Controlled photooxidation‐mediated disruption of collagens in the tumor microenvironment can reduce desmoplasia and enhance immune responsiveness. However, achieving effective light delivery to solid tumors, particularly those with dynamic volumetric changes like pancreatic ductal adenocarcinoma (PDAC), remains challenging limits repeated sustained photoactivation drugs. Here, 3D, shape‐morphing, implantable photonic devices (IPDs) are introduced that enable tumor‐specific continuous irradiation for metronomic photodynamic therapy (mPDT). This IPD adheres seamlessly surface orthotopic PDAC mitigating issues related mechanical mismatch, delamination, internal lesions. In freely moving mouse models, mPDT using close adhesion significantly reduces desmoplastic volume without causing cytotoxic effects healthy tissues. These promising vivo results underscore potential an adaptable unidirectional design precisely targeting cancerous organs, suggesting a meaningful advance light‐based therapeutic technologies.

Language: Английский

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Liquid Metal Encased in Biomimic Polydopamine Armor to Reinforce Photothermal Conversion and Photothermal Stability

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: 19(6)

Published: Feb. 7, 2024

Abstract Liquid metal (LM) faces numerous obstacles like spontaneous coalescence, prone oxidizability, and deterioration in photothermal conversion, impeding the potential application as agent. To tackle these issues, several studies have focused on surface engineering strategy. Developing a feasible efficient strategy is crucial to prevent aggregation coalescence of LM, while also ensuring exceptional conversion biosecurity. In order achieve goals this work, biomimetic polydopamine (PDA) armor was chosen encase typical LM (eutectic gallium‐indium‐tin alloy) via self‐polymerization. Characterization results showed that PDA encased nanoparticle exhibited enhanced stability, biosecurity, which could be derived from following factors: (1) The protective shell acted an “armor”, isolating dissolved oxygen water, inhibiting heating‐accelerated oxidation shape morphing. (2) near‐infrared absorption conducive conversion. (3) characteristic advantageous for improving Hence, work presented new reinforce application.

Language: Английский

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