Interactions Between Radiotherapy Resistance Mechanisms and the Tumor Microenvironment DOI
Dengxiong Li, Jie Wang, Xinrui Li

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705

Published: March 1, 2025

Language: Английский

Genetically Engineered Magnesium/Manganese Nanoparticles for Cancer Radioimmunotherapy DOI

Jicheng Wu,

Yangtao Xu, Yunjing Zhang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mitochondrion‐Targeted Type I Photodynamic Therapy for Agonist Independent cGAS‐STING Activation DOI
Yin Xu,

Dongmin An,

Tian Zhang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

CGAS-STING agonists generally lead to hyperimmunity and systemic toxicity, hindering their immunotherapeutic outcomes. Herein, a mitochondrion-targeted nanoagonist (termed HABH) containing boron dipyrromethene (BODIPY)-derived type I photosensitizer (BDP) Au nanoparticle-engineered hollow mesoporous silica (HMSN/AuNPs) has been fabricated for light-controlled mitochondrial stress-inducing agonist-independent cGAS-STING pathway activation. The HABH can actively target tumor tissues release the BDP. Under light illumination, BDP achieves photodynamic therapy (PDT) in mitochondria, generating massive hydroxyl radicals (•OH) inducing stress an oxygen-independent manner, promoting of DNA (mtDNA). Simultaneously, HMSN/AuNPs act as dual nanozymes derive cascade reactions •OH production, elevating intracellular oxidative state, together with BDP-induced stress, finally evoking facilitating interferon. In orthotopic breast models, achieved intratumoral immunoactivation eradicating primary tumors preventing metastasis tumors. Therefore, constructed enabled activation, providing paradigm photoimmunotherapy.

Language: Английский

Citations

0
Acidity-Unlocked Glucose Oxidase as Drug Vector to Boost Intratumor Copper Homeostatic Imbalance-Enhanced Cuproptosis for Metastasis Inhibition and Anti-Tumor Immunity DOI
Junrong Wang, Yulin Xie, Guo‐Qing Zhu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 319, P. 123207 - 123207

Published: Feb. 28, 2025

Language: Английский

Citations

0
Oxygen-regulated enzymatic nanoplatform for synchronous intervention in glycolysis and oxidative phosphorylation to augment antitumor therapy DOI
Shanshan Jiang, Wanyu Li, Yifan Zhang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113594 - 113594

Published: Feb. 28, 2025

Language: Английский

Citations

0
Interactions Between Radiotherapy Resistance Mechanisms and the Tumor Microenvironment DOI
Dengxiong Li, Jie Wang, Xinrui Li

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705

Published: March 1, 2025

Language: Английский

Citations

0