Photocages Made to Order: Late-Stage Caging Protocol Enables Anti-Cancer Control with Near-Infrared Light

Published: July 24, 2024

Nature has perfected the reversible control over activity of molecules and biomolecules in human body. Photocages aim to mimic this space time using light as a trigger, field witnessed many excellent contributions that extend their use tissue-penetrating region. Yet little attention been paid developing simple caging strategies which are crucial translate photocages into widely accepted tool beyond chemical space. Here, we report robust user-friendly protocol enables installation amine, thiol phenol payloads single step under mild conditions bench-stable intermediates. The displays compatibility with payloads, manifested by hormones, neurotransmitters, tripeptide highly complex FDA-approved drugs, including antibiotics or anti-cancer agents. In proof-of-concept study, utilize strategy cage clinically used CDK4/6 inhibitor palbociclib tumor suppressing retinoblastoma protein breast cancer cells near-infrared (NIR) light. We anticipate normalizing access NIR-absorbing through will empower research across various scientific disciplines.

Language: Английский

Surfing the Limits of Cyanine Photocages One Step at a Time

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Near-infrared light-activated photocages enable controlling molecules with tissue penetrating light.

Language: Английский