Alkali-Cation-Selective Arylation Promoted by Ion Recognition of Foldamers DOI

Chenhao Yao,

Zhaocheng Xu,

Jun Tian

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

To explore alkali-cation selectivity at the chemical reaction level, in this work, we for first time focused on different behaviors of potassium and sodium ions intra- intermolecular arylation. We prepared a series aromatic foldamers based pyridine/oxadiazole alternating sequences as catalysts Our studies revealed that can selectively recognize K+ over Na+ interactions between drive arylation with significant yield. In contrast, no trace product be found Na+. Furthermore, foldamers, biased handedness, afford products optical activity. The balance two enantiomers freely controlled by conformations foldamers.

Language: Английский

Self-assembled K+ ion channel constructed by a Janus-type self-complementary molecule DOI

Shihao Pang,

Chuantao Wang, Tianlong Li

et al.

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Embedding Carbon Nanotubes in Artificial Cells Enhances Probe Transfer DOI Open Access

Junwen Wu,

Xuemin Zeng,

Lina Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Monitoring intracellular biomarkers is crucial for clinical disease diagnosis. However, the majority of signaling molecules face difficulties in slow transference across cell membrane to reach detection sites, limiting their application settings. This study proposes an artificial cell-based signal probe transfer-enhanced sensing strategy effectively detect microRNAs (miRNAs) by embedding carbon nanotubes (CNTs) membranes. The liposome-based constructed protect probes such as nucleic acids, metal ions, and fluorescent dyes. CNTs are embedded membranes employed channels enhance intercellular transduction mass transfer. Through CNTs-mediate cell-cell transmission, pass through liposome interface fuse into target cells, selectively hybridizing with miRNAs, triggering a process resulting enhanced fluorescence signal. Furthermore, molecular dynamics simulations carried out prove enhancement CNTs-mediated fusion. demonstrates excellent analytical performance quantitatively detecting let-7a miRNA visualizing it living colon cancer cells. These findings hold great significance promoting accelerating transmission enabling effective diagnostic purposes.

Language: Английский

Citations

0
Creating Sodium Ion Channels via De Novo Encapsulation of Ionophores for Enhanced Water Energy Harvesting DOI
Qing Guo, Zhiwei Xing,

Huaxi Guo

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Biological ion channels achieve remarkable permselectivity and cation discrimination through the synergy of their intricate architectures specialized ionophores within confined nanospaces, enabling efficient energy conversion. Emulating such selectivity in synthetic nanochannels, however, remains a persistent challenge. To address this, novel host‐guest assembly membrane is developed by incorporating sodium‐selective into β‐ketoenamine‐linked covalent organic framework (COF). This design confers exceptional Na + selectivity, achieving /K /Li ratios 3.6 103, respectively, along with near‐perfect /Cl − under 0.5 M || 0.01 salinity gradient. Notably, dynamically switches its to favor anion transport presence high‐valent cations (e.g., Ca 2+ ), overcoming limitations as uphill diffusion back currents observed conventional cation‐selective membranes. adaptive behavior yields 4.6‐fold increase output power density ‐rich environments. These findings advance biomimetic nanochannels unparalleled enhanced conversion efficiency.

Language: Английский

Citations

0
Aromatic foldamer-derived transmembrane transporters DOI
Danyang Zhang, Wenju Chang, Jie Shen

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

1-2 Sentences highlighting the novelty of work In this review, we provide a very first comprehensive exposition artificial potassium transporters derived from aromatic foldamers mostly over past ten years.

Language: Английский

Citations

3
Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system DOI Creative Commons
Pengyang Xin,

Wenke Ren,

Qiuhui Zhu

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(37), P. 26933 - 26937

Published: Jan. 1, 2024

The carboxyl-modified ion permeation pathway in TRPA1 channel protein was reconstructed an artificial system. transport activity of this is tunable via external pH due to the carboxyl groups pathway.

Language: Английский

Citations

0
Synthetic ion channels in biomembranes DOI Creative Commons
Ai Kohata, Kazushi Kinbara

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 84, P. 102544 - 102544

Published: Nov. 20, 2024

Language: Английский

Citations

0
Biomimetic ion channels: an emerging and promising material for therapeutic ion channelopathies DOI Creative Commons

Shengnan Ren,

Zhanyi Zhang, Zeyuan Dong

et al.

Trends in Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Foldamer-mediated transport across phospholipid bilayers DOI

Iqra Zubair,

Luis Martínez‐Crespo, Simon J. Webb

et al.

Current Opinion in Chemical Biology, Journal Year: 2024, Volume and Issue: 84, P. 102549 - 102549

Published: Nov. 30, 2024

Language: Английский

Citations

0
Alkali-Cation-Selective Arylation Promoted by Ion Recognition of Foldamers DOI

Chenhao Yao,

Zhaocheng Xu,

Jun Tian

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

To explore alkali-cation selectivity at the chemical reaction level, in this work, we for first time focused on different behaviors of potassium and sodium ions intra- intermolecular arylation. We prepared a series aromatic foldamers based pyridine/oxadiazole alternating sequences as catalysts Our studies revealed that can selectively recognize K+ over Na+ interactions between drive arylation with significant yield. In contrast, no trace product be found Na+. Furthermore, foldamers, biased handedness, afford products optical activity. The balance two enantiomers freely controlled by conformations foldamers.

Language: Английский

Citations

0