Self‐promoted Controlled Ring‐opening Polymerization via Side Chain‐mediated Proton Transfer for the Synthesis of Tertiary Amine‐pendant Polypeptoids DOI Open Access

Mingzhen Liao,

Yao Yao,

Kunyu Gan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Proton transfer is essential in virtually all biochemical processes, with enzymes facilitating this by optimizing the proximity and orientation of reactants through site‐specific hydrogen bonds. also crucial rate‐determining step for ring‐opening polymerization N ‐carboxyanhydrides (NCAs), widely used to prepare various peptidomimetic materials. This study utilizes side chain‐assisted strategy accelerate rate chain propagation using NCAs tertiary amine pendants. moiety enables bond formation between incoming NCA polymer amino growing end. The forms a proton shuttle, via less constrained transition state, facilitate process. Moreover, chains enable precipitation monomers situ protonation during monomer synthesis. greatly facilitates synthesis these unreported monomers, allowing direct controlled amine‐pendant polypeptoids. chain‐promoted has rarely been reported. Additionally, chains, as functional groups, endow polymers unique properties including pH‐ thermo‐responsiveness, tunable p K s, siRNA transfection capability. self‐promoted synthesis, facile preparation, attractive make polypeptoids promising materials applications.

Language: Английский

Easy access to amphiphilic nitrogenous block copolymers via switchable catalysis DOI Creative Commons
Xue Liang,

Jiachen Lv,

Hongru Qiang

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A key challenge in polymer synthesis is to develop new methods that enable block copolymers be prepared from mixed monomer feedstock. The emerging switchable polymerization catalysis can generate with well-defined structures and tunable properties mixtures. However, constrained by the reactivity of monomers incompatibility different mechanisms, this method usually confined oxygenated monomers. In work, was successfully applied nitrogenous for first time, achieving efficient copolymerization

Language: Английский

Citations

0
Self‐promoted Controlled Ring‐opening Polymerization via Side Chain‐mediated Proton Transfer for the Synthesis of Tertiary Amine‐pendant Polypeptoids DOI Open Access

Mingzhen Liao,

Yao Yao,

Kunyu Gan

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Proton transfer is essential in virtually all biochemical processes, with enzymes facilitating this by optimizing the proximity and orientation of reactants through site‐specific hydrogen bonds. also crucial rate‐determining step for ring‐opening polymerization N ‐carboxyanhydrides (NCAs), widely used to prepare various peptidomimetic materials. This study utilizes side chain‐assisted strategy accelerate rate chain propagation using NCAs tertiary amine pendants. moiety enables bond formation between incoming NCA polymer amino growing end. The forms a proton shuttle, via less constrained transition state, facilitate process. Moreover, chains enable precipitation monomers situ protonation during monomer synthesis. greatly facilitates synthesis these unreported monomers, allowing direct controlled amine‐pendant polypeptoids. chain‐promoted has rarely been reported. Additionally, chains, as functional groups, endow polymers unique properties including pH‐ thermo‐responsiveness, tunable p K s, siRNA transfection capability. self‐promoted synthesis, facile preparation, attractive make polypeptoids promising materials applications.

Language: Английский

Citations

0