Rapid and Differential Diagnosis of Sepsis Stages Using an Advanced 3D Plasmonic Bimetallic Alloy Nanoarchitecture‐Based SERS Biosensor Combined with Machine Learning for Multiple Analyte Identification
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Rapid
and
accurate
differential
diagnosis
of
infections,
sepsis,
septic
shock
is
essential
for
preventing
unnecessary
antibiotic
overuse
improving
the
chance
patient
survival.
To
address
this,
a
3D
gold
nanogranule
decorated
gold‐silver
alloy
nanopillar
(AuNG@Au‐AgNP)
based
surface‐enhanced
Raman
scattering
(SERS)
biosensor
developed,
capable
quantitatively
profiling
immune‐related
soluble
proteins
(interleukin
three
receptor,
alpha
chain:
CD123,
programmed
cell
death
ligand
1:
PD‐L1,
human
leukocyte
antigen–DR
isotype:
HLA‐DR,
chitotriosidase:
ChiT)
in
serum
samples.
The
bimetallic
nanoarchitecture,
fabricated
using
anodized
aluminum
oxide
(AAO),
features
uniform
structure
with
densely
packed
nanogaps
on
heads
Au‐Ag
nanopillars,
enabling
fast,
simple,
replicable
production.
proposed
achieves
results
even
low
detection
limits
(4–6
fM)
high
signal
consistency
(relative
standard
deviation
(RSD)
=
1.79%)
within
one‐step
multi‐analytes
identification
chip
directly
loadable
chamber.
enhance
diagnostic
performance,
support
vector
machine
(SVM)
learning
algorithm
utilized,
achieving
95.0%
accuracy
95.8%
precision
classifying
healthy
controls,
infections
without
shock.
This
advanced
plasmonic
nanoarchitecture‐based
SERS
demonstrates
clinical
usefulness
sepsis
severity
assessment,
providing
timely
personalized
treatment.
Language: Английский
Nanofabrication for Nanophotonics
Younghwan Yang,
No information about this author
Youngsun Jeon,
No information about this author
Zhaogang Dong
No information about this author
et al.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Nanofabrication,
a
pivotal
technology
at
the
intersection
of
nanoscale
engineering
and
high-resolution
patterning,
has
substantially
advanced
over
recent
decades.
This
enables
creation
nanopatterns
on
substrates
crucial
for
developing
nanophotonic
devices
other
applications
in
diverse
fields
including
electronics
biosciences.
Here,
this
mega-review
comprehensively
explores
various
facets
nanofabrication
focusing
its
application
nanophotonics.
It
delves
into
techniques
like
focused
ion
beam
electron
lithography,
methods
3D
complex
structure
fabrication,
scalable
manufacturing
approaches,
material
compatibility
considerations.
Special
attention
is
given
to
emerging
trends
such
as
utilization
two-photon
lithography
structures
materials
phase
change
substances
2D
with
excitonic
properties.
By
highlighting
these
advancements,
review
aims
provide
insights
ongoing
evolution
nanofabrication,
encouraging
further
research
creating
functional
nanostructures.
work
encapsulates
critical
developments
future
perspectives,
offering
detailed
narrative
state-of-the-art
tailored
both
new
researchers
seasoned
experts
field.
Language: Английский
Dual SERS enhancement based on Ag@Au Nanopizza combined with superhydrophobic silicon substrate for the detection of early bladder cancer marker-APOA1
Hangzhuo Li,
No information about this author
Jian Zhu,
No information about this author
Guojun Weng
No information about this author
et al.
Sensors and Actuators B Chemical,
Journal Year:
2024,
Volume and Issue:
unknown, P. 137013 - 137013
Published: Nov. 1, 2024
Language: Английский
Iron ore pellets based-Ag2O nanoparticles as efficient Bi-functional heterogeneous catalyst for the synthesis tetrahydrobenzo[α]xanthens in green media
Frontiers in Chemistry,
Journal Year:
2025,
Volume and Issue:
13
Published: March 19, 2025
Through
the
use
of
a
microwave,
iron
ore
pellets
(IOP)-based
Ag
2
O
nanoparticles
were
successfully
synthesized.
They
then
characterized
by
means
vibrating
sample
magnetometer
(VSM),
Brunauer-Emmett-Teller
(BET)
surface
area
analysis,
energy-dispersive
X-ray
(EDX)
powder
diffraction
(XRD)
EDX
elemental
mapping,
and
field
emission
scanning
electron
microscopy
(FESEM).
High
quantities
tetrahydrobenzo[a]xanthen
derivatives
obtained
in
brief
amount
time
newly
prepared
nanocomposite,
known
as
NP@IOP,
one-pot,
three-component
reaction
involving
different
aryl
aldehydes,
naphthol,
dimedone.
There
is
no
appreciable
loss
catalytic
activity
when
catalyst
recycled
utilized
several
times,
it
can
be
easily
retrieved
using
an
external
magnet.
The
reason
for
functionality
designed
hybrid
related
to
textural
properties
such
desirable
specific
significant
porosity
well
structural
nature
NP@IOP
catalyst.
Language: Английский
Scalable Purification of Gold Nanocubes via Centrifugal Depletion-Induced Flocculation: A Pathway to High-Precision Nanomaterials
ACS Applied Nano Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 21, 2025
Language: Английский
Synthesis of Homogeneous Plasmonic Nanostructures for Generating Uniform and Reproducible Photonic Environments
Yeo Hyung Kim,
No information about this author
Young Sook Kwak,
No information about this author
Ji-Hyeon Choi
No information about this author
et al.
Accounts of Materials Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Language: Английский
Plasmon–Exciton Strong Coupling in Colloidal Au Nanocubes with Layered Molecular J-Aggregates
Nano Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 7, 2024
Strong
coupling
between
light
and
matter
forms
hybrid
states,
such
as
exciton-polaritons,
which
are
crucial
for
advancements
in
quantum
science
technology.
Plasmonic
metal
nanoparticles,
with
their
ultrasmall
mode
volumes,
effective
generating
these
but
the
strength
is
often
limited
by
surface
saturation
of
excitonic
materials.
Additionally,
cubic
can
generate
strong
local
fields,
have
not
been
systematically
explored.
This
study
investigates
Au
nanocubes
(AuNCs)
coupled
J-aggregates,
observing
spectral
splitting
both
extinction
scattering
spectra.
Our
findings
suggest
that
smaller
AuNCs,
higher-quality
resonances
reduced
achieve
stronger
coupling.
Furthermore,
a
layer-by-layer
(LBL)
coating
J-aggregates
on
AuNCs
results
∼21%
increase
strength.
Simulations
reveal
mechanism
behind
enhanced
confirm
layering
method
effectively
increases
coupling,
surpassing
limitations
finite
area
nanoparticles.
Language: Английский