Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy DOI

Guanjie Shi,

Yongxuan Zhang,

Wenting Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Considering the strong electron‐donating ability and superior biocompatibility, integration of zero‐valent iron nanostructure Fe 0 (electron‐reservoir) boron B offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, controlled facile synthesis alloyed nanostructure‐FeB nanometallic glasses (NMGs) has remained a long‐standing challenge. Herein, complexion‐reduction strategy is proposed FeB NMGs with greater electron donating capacity to activate molecular oxygen improved therapy. In‐depth mechanism reveales that effectively prevent long‐range diffusion , resulting in amorphous nanoparticles (FeB NPs). The NPs display stronger capability transfer rate 9.4 times higher than NPs, which produce ∙O 2 − H O ∙OH. vitro cellular experiments confirm FeB‐ss‐SiO₂ (encapsulation SiO outlayer containing ‐S‐S‐ bonds) demonstrates enhanced ferroptosis. tumor‐bearing mice models shows exhibited biocompatibility tumor inhibition effect (inhibition 73%), improve overall survival 30 days post‐treatment. This study will provide an innovative way design therapeutic nanoagents cancer treatments.

Language: Английский

Nanoparticle Vaccine Triggers Interferon-Gamma Production and Confers Protective Immunity against Porcine Reproductive and Respiratory Syndrome Virus DOI

Yangyang Sun,

Yanni Gao,

Tongjian Su

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

The swine industry annually suffers significant economic losses caused by porcine reproductive and respiratory syndrome virus (PRRSV). Because the available commercial vaccines have limited protective efficacy against epidemic PRRSV, there is an urgent need for innovative solutions. Nanoparticle induce robust immune responses become a promising direction in vaccine development. In this study, we designed produced self-assembling nanoparticle derived from thermophilic archaeal ferritin to combat PRRSV. First, multiple T cell epitopes targeting viral structural proteins were identified IFN-γ screening after PRRSV infection. Three different self-assembled nanoparticles with GP3, GP4, GP5 constructed mixed generate FeCocktail vaccine. Experiments showed that effectively activated CD4+ CD8+ cells effector memory mice. Piglets immunized generated specific antibodies exhibited increased levels of PRRSV-specific functional cells. also provided challenge, including mitigation clinical symptoms, reduction loads serum lungs, alleviation lung tissue damage. conclusion, study offers candidate combating affirms utility protein as platform next-generation

Language: Английский

Citations

1
Strategies for engineering biomimetic materials for tumor therapy DOI
Zhaoyu Ma, Kai Zhang,

Yanli Zhao

et al.

Matter, Journal Year: 2025, Volume and Issue: 8(1), P. 101899 - 101899

Published: Jan. 1, 2025

Language: Английский

Citations

0
Regulation of ferroptosis by nanotechnology for enhanced cancer immunotherapy DOI
Haohan Zhou, Yiyun Cheng,

Quan Huang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2024, Volume and Issue: 21(6), P. 921 - 943

Published: June 2, 2024

Introduction This review explores the innovative intersection of ferroptosis, a form iron-dependent cell death, with cancer immunotherapy. Traditional treatments face limitations in efficacy and specificity. Ferroptosis as new paradigm biology, targets metabolic peculiarities cells may potentially overcome such limitations, enhancing

Language: Английский

Citations

3
Induced Ferroptosis Pathway by Regulating Cellular Lipid Peroxidation With Peroxynitrite Generator for Reversing “Cold” Tumors DOI
Ruipeng Li, Haitao Yuan,

Chuangxin Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Overcoming the resistance of tumor cells to apoptosis and immunosuppression is an important challenge improve immunotherapy. Non‐apoptotic death mode ferroptosis has been regarded as a new strategy enhance immunotherapy against drug‐resistant cancers. The lethal accumulation lipid peroxides (LPO) determines progress ferroptosis. high susceptibleness provides opportunity for combating triple‐negative breast cancer. Reactive nitrogen species (RNS) produced by nitric oxide (NO) reactive oxygen (ROS) more than ROS cells. Herein, RNS‐mediated inducing pathway proposed improving LPO accumulation, constructed multifunctional liposome (Lipo‐MT‐SNAP) comprised peroxynitrite (ONOO − ) generator, targeted group, inhibiting glutathione peroxidase 4 (GPX4), basic units (dipalmitoyl phosphatidylcholine cholesterol). significant enhancement resulted from intense oxidative damage ONOO impaired synthesis GPX4 depleting glutathione, which further amplified triggered immunogenic cell death. In vivo, photoimmunotherapy can promote polarization M2 M1 macrophages dendritic maturation, infiltrate T cells, regulate secretion inflammatory factors, reprogram microenvironment. powerful induces strong immunogenicity effectively inhibit proliferation.

Language: Английский

Citations

2
Current progress in the regulation of endogenous molecules for enhanced chemodynamic therapy DOI Creative Commons
Jun Wang, Yina Liu, Tingting Cui

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(26), P. 9915 - 9926

Published: Jan. 1, 2024

A comprehensive summary of how different endogenous molecules' metabolic processes (including H 2 O , iron, lactate, GSH, and lipid metabolisms) impact Fenton chemistry is provided in this perspective for advancing chemodynamic therapy against cancer.

Language: Английский

Citations

1
Ferrocene-Conjugated Paclitaxel Prodrug for Combined Chemo-Ferroptosis Therapy of Cancer DOI

Shaojin Lu,

Dengyuan Hao,

Qian Meng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(36), P. 47325 - 47336

Published: Aug. 27, 2024

Herein, we developed a paclitaxel prodrug (PSFc) through the conjugation of (PTX) and ferrocene

Language: Английский

Citations

1
Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy DOI
Hong Deng, Jiayu Chen, Huimin Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 351, P. 123123 - 123123

Published: Dec. 6, 2024

Language: Английский

Citations

0
Controlled Synthesis of the FeB Nanometallic Glasses with Stronger Electron Donating Capability to Activate Molecular Oxygen for the Enhanced Ferroptosis Therapy DOI

Guanjie Shi,

Yongxuan Zhang,

Wenting Wang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 8, 2024

Abstract Considering the strong electron‐donating ability and superior biocompatibility, integration of zero‐valent iron nanostructure Fe 0 (electron‐reservoir) boron B offers great promise for fabricating novel ferroptosis nanoagents. Nevertheless, controlled facile synthesis alloyed nanostructure‐FeB nanometallic glasses (NMGs) has remained a long‐standing challenge. Herein, complexion‐reduction strategy is proposed FeB NMGs with greater electron donating capacity to activate molecular oxygen improved therapy. In‐depth mechanism reveales that effectively prevent long‐range diffusion , resulting in amorphous nanoparticles (FeB NPs). The NPs display stronger capability transfer rate 9.4 times higher than NPs, which produce ∙O 2 − H O ∙OH. vitro cellular experiments confirm FeB‐ss‐SiO₂ (encapsulation SiO outlayer containing ‐S‐S‐ bonds) demonstrates enhanced ferroptosis. tumor‐bearing mice models shows exhibited biocompatibility tumor inhibition effect (inhibition 73%), improve overall survival 30 days post‐treatment. This study will provide an innovative way design therapeutic nanoagents cancer treatments.

Language: Английский

Citations

0