Metabolic Acidity/H2O2 Dual‐Cascade‐Activatable Molecular Imaging Platform toward Metastatic Breast Tumor Malignancy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR-II probes are limited by either being "always on" or responding to one stimulus, leading low signal-to-noise ratios potential false positives. We introduced a dual-lock-controlled probe, HN-PBA, activated both H

Language: Английский

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Donor–Acceptor Type Solvatochromic Flavonoid Materials Fluorphores for Polarity Sensing and Real‐Time Temperature Monitoring

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract Electron donor–acceptor (D–A) molecules are emerging tools for designing sensitive luminogens, attracting significant research attention. However, due to poor quantum yields under certain conditions, current D–A fluorophores often suffer from fluorescence quenching in practical applications. Developing new dyes and functional composites is crucial expanding their Here, a novel type flavonoid dye molecule, namely “AFL”, exhibiting both polarity‐dependent emission wavelength shift viscosity‐dependent intensity change, polarity measurement temperature sensing designed synthesized. Because the intramolecular charge transfer (ICT) can be enhanced by decrease of excited state energy caused high‐polarity organic solvents, AFL undergoes that shows color response solvents different polarities hence differentiates between them. Moreover, actual monitored as‐designed AFL@tetradecanoic acid (AFL@TA) sensor. By combining with TA, viscosity sensitively changes upon change insoluble composites, thus realizing temperature. Remarkable recyclable performance satisfactory mechanical properties integrated. This study provides promising approach developing fluorescent probe furnishes perspectives on potential such material stimuli‐responsive systems focus visualization technology.

Language: Английский

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Nanoprobe Based on Novel NIR‐II Quinolinium Cyanine for Multimodal Imaging

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Abstract NIR‐II imaging has the advantages of high sensitivity, spatiotemporal resolution, and penetration depth, thereby serving as a potential alternative to conventional methods. Herein, novel dye IR‐1010 ( λ ex / em = 1010/1058 nm) is reported with quantum yield (3.08%) good stability, by incorporating p‐methoxyphenyl groups into quinolinium cyanine dye. Then multifunctional nanoprobe, termed IUFP NPs , developed incorporation upconversion (UC) nanoparticles (NPs), perfluoro‐15‐crown‐5‐ether (PFCE), IR‐1010, display performance multimodal imaging. Under single‐wavelength excitation (980 nm), simultaneously emit fluorescence visible UC luminescence UCNPs, thus realize for cells, fluorescence/photoacoustic/ 19 F magnetic resonance blood vessels, lymph nodes tumor in mice. This work affords approach dyes general strategy design probes.

Language: Английский

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A Cascade Activation Probe with Double-Enhanced Near-Infrared Imaging for Monitoring Peroxynitrite Fluctuations in Vivo

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(44), P. 17657 - 17664

Published: Oct. 23, 2024

Monitoring peroxynitrite (ONOO

Language: Английский

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A Superoxide Anion Activatable 7-Azaindole Derived Photoacoustic Probe for High-Contrast Imaging of Drug-Induced Liver Injury

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: unknown, P. 136953 - 136953

Published: Nov. 1, 2024

Language: Английский

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