Lipophilicity Modulation of Fluorescent Probes for In Situ Imaging of Cellular Microvesicle Dynamics

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Real-time monitoring of dynamic microvesicles (MVs), vesicles associated with living cells, is great significance in deeply understanding their origin, transport, and function. However, specific labeling MVs poses a challenge due to the lack unique biomarkers that differentiate them from other cellular compartments. Here, we present strategy selectively label by evaluating series lipid layer-sensitive cationic indolium-coumarin fluorescent probes (designated as IC-Cn, n ranging 1 18) feature varying aliphatic side chains (CnH2n+1). Through situ cell imaging analysis, found IC-Cn location highly related lipophilicities phospholipid layer hydrophobic microenvironments In detail, IC-C1 IC-C2 specifically localize both inside outside cells. contrast, IC-C3, IC-C4, IC-C5 mitochondria but distinct fluorescence lifetimes. Using these strategically, have discovered that, addition biogenesis plasma membranes damaged mitochondria, newly formed can undergo fusion fission processes. Moreover, mitochondria-derived MVs, beyond being released parent fuse lysosomes facilitate removal dysfunctional mitochondria. The work not only provides new insights into MV physiology also inspires design strategies for used studies.

Language: Английский

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Multi-mode geometrically gated encryption with 4D morphing hydrogel

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 22, 2025

Leveraging the rich stimuli-response of polymers represents a promising direction towards optical communication/encryption. Sign language, which relies on specific geometric change for secured communication, has been widely used same purpose since ancient time. We report strategy that combines both in validated manner with hydrogel not only carries encrypted information but also hidden behavior to morph geometrically. In particular, shape morphing is programmable by controlling oriented state polymer chain thermo-responsive network. Whether positive (bending) or negative (flattening) cannot be predicted when polymerization methods are informed, revealing manner. Through deciphering coupling elastic stresses and thermo-induced deswelling stress, can perform designed diversified 4D evolution 3D geometries time as fourth dimension. Consequently, corresponding gated based these features, thereby decrypting correct permutation information. Our approach utilizes verification offers enhancing security communication ways quite different from existing strategies. Stimuli responsive hydrogels always complex required. Here, authors use

Language: Английский

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Mechanoluminescence from Organic–Inorganic Metal Halide Perovskite Derivative

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Metal halide perovskites and their derivatives are gaining significant attention as photoluminescent materials due to exceptional light-emitting properties. However, most research has concentrated on electroluminescence photoluminescence, there remains a substantial gap in the exploration of mechanoluminescence (ML) properties perovskites, making this field largely uncharted. ML is an ancient intriguing luminescent phenomenon that occurs when material subjected mechanical forces. Here, discovery first organic-inorganic hybrid terbium (Tb3+)-based metal halide, type perovskite derivative, which exhibits notable reported. Through orthogonal design, critical roles played by molecular geometry metal-site ions achieving remarkable halides identified.

Language: Английский

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Optimized Photochromic Performance of Spiropyran through Incorporation into Hydrogen-Bonded Organic Frameworks and Applications in Anticounterfeiting and Information Encryption

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Photostimulus-responsive fluorescent materials are promising for anticounterfeiting and UV printing due to rapid response simple preparation. In this paper, we propose a novel strategy prepare photostimulus-responsive SP@HOF-olefin by integrating the photochromic molecule spiropyran (SP) with postsynthetic modified hydrogen-bonded organic frameworks (HOF-olefin). Compared SP@HOF, composites exhibit enhanced properties, such as fast speed, pronounced color contrast, exceptional fatigue resistance. The improvements can be attributed reduction of residual carboxyl groups in framework, which subsequently decreases polarity framework. Besides, SP loading content was significantly enhanced. Furthermore, HOF-olefin transformed into HOF films via photopolymerization. These demonstrated excellent flexibility, folded twisted at any angle ranging from 0 180°. By utilizing photomask method, letters "Z", "T", "S", "U", along other patterns were successfully imprinted on film. investigated utilization these advanced applications. This work serves representative case demonstrating how functionalized HOFs improved properties SP, showcasing potential applications information encryption.

Language: Английский

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Progress Toward Sustainable Polymer Technologies with Ball-Mill Grinding

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: unknown, P. 101900 - 101900

Published: Oct. 1, 2024

Language: Английский

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Harnessing the enol/keto-form emission of ESIPT: mechanochromism, multi-channel imaging, and detection of a chemical warfare agent mimic

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

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AIE and ICT Synergistic Lysosome-Targeted Ratiometric Fluorescence Sensor for the Detection and Imaging of Th⁴⁺ in the Liver of Zebrafish and Mice

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

The sensitive detection of the radioactive thorium (Th) ion with an oxidation state +4 (Th4+) is great significance for environmental protection and life safety. In this study, five fluorescence sensors regulated donor-acceptor (D-A) interactions were constructed Th4+ based on intramolecular charge transfer aggregation-induced emission mechanisms. Among developed sensors, TPE-D bearing electron-deficient π-bridge weak D-A presented ratiometric behavior toward in aqueous solution due to its characteristics unique D-A-D structures. Moreover, showed excellent selectivity sensitivity detection, limit was as low 8.1 × 10-8 M. sensing mechanism observation revealed that could coordinate hydroxyl, imine, carbonyl groups accompanied by electron process. addition, selectively be enriched lysosome. Both lysosome liver mice zebrafish realized strategy, a mobile-assisted approach actual water samples also established high sensitivity. This first report organelles organs, which provides reliable strategy radionuclide toxicology analysis applications.

Language: Английский

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Balancing the Chain Flexibility and Rigidity of Crosslinked Polyacrylic Acid Toward Optimized Fluorescence Quantum Yield

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

ABSTRACT The balance of chain flexibility and rigidity may improve the fluorescence quantum yields (QYs) unconventional aggregation‐induced emission (AIE) polymers. Herein, we prepared four crosslinked polyacrylic acids (CPAAs) with AIE effect using N,N′ ‐methylene bisacrylamide (MBA) as crosslinker. CPAAs decreases increase MBA contents. These show bright blue under irradiation UV light. maximum excitation wavelengths are not near their absorption peaks because is originated from clustering oxygen atoms carbonyl groups, but ( n , π *) transition atoms. spectra fluorescent lifetime data both validate that all have similar species. Density functional theory calculations suggest comes carboxyl groups. One balanced has an optimized QY 17.7%, which much higher than reported linear PAA 4.5%.

Language: Английский

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The Influence of Endogenous Derivatives on the Self-Assembly of Carbonized Polymer Dots

Solids, Journal Year: 2025, Volume and Issue: 6(1), P. 14 - 14

Published: March 20, 2025

Carbonized polymer dots (CPDs) have emerged as a fascinating class of functional nanomaterials with unique physicochemical properties. However, the mechanisms governing their formation and photoluminescence remain subject intense debate. In this study, we conducted systematic comparison structural, morphological, optical properties CPDs synthesized using various methods, revealing self-assembly characteristics low-molecular-weight relatively complex structures. Through comprehensive analyses, found that fewer endogenous derivatives exhibited pronounced concentration-dependent self-assembly, leading to larger particle sizes enhanced fluorescence emission at higher concentrations. contrast, proportions showed limited due supramolecular interactions between chains. Remarkably, removal ternary solvent extraction method significantly CPDs. These findings highlight critical role in modulating photophysical CPDs, paving way for future advancements field.

Language: Английский

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Triple Effects of Fe³⁺ for the Integration of Mechanical Robustness, Reprocessability, and Unprecedented Thermal Stability into Polydimethylsiloxane

Macromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

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