Strained diradicaloids for σ-bond-insertion reactions: A breakthrough in drug discovery
Yoshio Barrera,
No information about this author
Florian F. Mulks
No information about this author
Chem,
Journal Year:
2025,
Volume and Issue:
unknown, P. 102524 - 102524
Published: March 1, 2025
Language: Английский
Constructing Nitrogen-Rich Fused [5,6,5]-Tricyclic Frameworks Through Rearrangement: Heat-Resistant Zwitterionic Salt Energetic Materials
Xiangyan Miao,
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Jaehoon H. Yu,
No information about this author
Yuchuan Li
No information about this author
et al.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(47), P. 10085 - 10089
Published: Nov. 8, 2024
This
study
synthesized
nitrogen-rich
[5,6,5]
fused
compounds
through
a
novel
rearrangement
reaction.
Owing
to
its
unique
zwitterionic
salt
structure,
product
4-1
exhibits
high
thermal
stability
(Td
>
250
°C),
low
sensitivity
(IS
40
J,
FS
360
N),
and
acceptable
detonation
velocities
pressures
(νD
=
8520
m
s–1
P
32.53
GPa,
respectively),
which
are
better
than
those
of
TNT
TATB.
These
indicate
the
potential
salts
as
thermally
stable
energetic
materials
provide
new
synthesis
strategies
for
constructing
polycyclic
heterocycles
rearrangement.
Language: Английский
Geometric distortion as an enabling tool for organic synthesis
Luca McDermott,
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Zach G. Walters,
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Allison M. Clark
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et al.
Nature Synthesis,
Journal Year:
2025,
Volume and Issue:
4(4), P. 421 - 431
Published: April 9, 2025
Language: Английский
A RhII-Catalyzed [4 + 3]-Cycloaddition via the Stereoselective Cyclopropanation of Vinyl Allenes En Route to Oxepino[b]indoles and Subsequent Elaboration to Spirooxindole Frameworks
Ji-Yoon Kim,
No information about this author
Kevin X. Rodriguez,
No information about this author
Kaitlyn E. Eckert
No information about this author
et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Oxepino[b]indoles
were
obtained
in
good
to
excellent
yields
employing
a
[4
+
3]-cycloaddition
initiated
by
stereo-
and
regioselective,
RhII-catalyzed
cyclopropanation
between
vinyl
allene
diazooxindole
afford
an
intermediate
cyclopropyl
that
engaged
the
oxindole
carbonyl
spontaneous
hetero-[3,3]-rearrangement.
A
survey
of
functional
group
tolerance
revealed
diverse
array
substrates
amenable
oxepino[b]indole
formation.
In
addition
intriguing
architecture
cycloadducts,
exposure
either
Brønsted
acid
or
base
enables
assembly
functionalized
spirroxindoles
via
unusual
conversion
5-7
fused
ring
system
5-5
spirocycle.
Language: Английский
Diels–Alder Cycloadditions of Oxacyclic Allenes and α-Pyrones
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(30), P. 6465 - 6470
Published: July 24, 2024
Reactions
of
α-pyrones
with
oxacyclic
allenes
in
Diels–Alder
trappings
are
described.
We
investigate
regioselectivity
trends
and
perform
competition
experiments
to
assess
the
influence
structural
electronic
features
on
relative
reaction
rates.
also
demonstrate
stereospecific
trapping
an
allene,
which
proceeds
high
optical
yield.
This
study
provides
insight
into
strained
cyclic
allene
reactivity,
as
well
new
synthetic
tools
for
rapid
construction
complex,
heterocyclic
scaffolds.
Language: Английский
Spannende Moleküle
Nachrichten aus der Chemie,
Journal Year:
2024,
Volume and Issue:
72(11), P. 66 - 69
Published: Oct. 31, 2024
Abstract
Es
gibt
viele
Arten,
wie
organische
Moleküle
unter
Spannung
stehen
können.
Setzen
sie
diese
Energie
frei,
kommen
neue
Reaktionen
oder
Strukturen
heraus.
Einige
lassen
sich
nicht
nur
isolieren,
sondern
in
Medikamente
einbauen
–
und
ein
gespannter
Cyclus
war
Grund
für
einen
Nobelpreis.