Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 10, 2024
An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.
Language: Английский
Synthesis, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 29, 2024
Abstract We developed a Ni-catalyzed asymmetric reductive spirocyclization of 1,6-enynes with o-haloaryl aldehydes. This approach provides an efficient method for the construction chiral spiroindanone pyrrolidine derivatives in good yields excellent enantio- and diastereoselectivity (up to 99% ee, >20:1 dr). reaction does not require pre-prepared organometallic reagents exhibits substrate compatibility.
Language: Английский
Citations
0
Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 10, 2024
An enantioselective Pd/Cu-catalyzed sequential Heck/Sonogashira reaction of electron-rich enamides is reported, providing various 3-propargyl isoindolinone derivatives bearing quaternary stereogenic centers in good yield and enantioselectivity.
Language: Английский
Citations
0