Enantioselective Synthesis of Aminals Via Nickel-Catalyzed Hydroamination of 2-Azadienes with Indoles and N-Heterocycles DOI
Ya Du,

Shengzu Duan,

Shuntao Huang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(45), P. 30947 - 30957

Published: Oct. 30, 2024

New methods for the enantioselective synthesis of N-alkylated indoles and their derivatives are great interest because pivotal structural elements in biologically active molecules natural products. They also versatile intermediates organic synthesis. Among well-established asymmetric hydroamination methods, with indole-based substrates is a formidable challenge. This observation likely due to reduced nucleophilicity indole nitrogen. Herein, unique nickel-catalyzed enantio- branched-selective 2-azadienes structurally related N-heterocycles reported generation enantioenriched

Language: Английский

Photoinduced Pd-Catalyzed Formal Asymmetric Allylic Substitution of Piperidine Scaffolds DOI

Weidong Lu,

Zhilin Liu,

Zi‐Hao Liao

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 4384 - 4393

Published: Feb. 26, 2025

Language: Английский

Citations

1
Regioselective 1,4-Hydroamination of 1,3-Dienes by Photoredox/Cobalt Dual Catalysis DOI

Pei-Ting Li,

Quansheng Mou, Wei Yu

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Herein, we report a visible-light-driven and cobalt-mediated 1,4-hydroamination reaction of 1,3-dienes with arylmines as the nucleophiles. The involves regioselective addition [CoIII]–H to 1,3-diene, followed by oxidation nucleophilic substitution amines. Using Ir(ppy)3 photocatalyst enables cobalt redox cycle be implemented without using an external oxidant hydride regent. This protocol can applied well forge carbon–oxygen carbon–sulfur bonds in analogous way.

Language: Английский

Citations

0
Enantioselective 1,2-Carboamination of 1,3-Dienes with N-Hydroxyphthalimide (NHP) Esters Enabled by a Photoinduced Pd Catalysis DOI
Zhilin Liu,

Jia-Le Yan,

Kai Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Herein, a photoinduced, Pd-catalyzed direct 1,2-carboamination of conjugated 1,3-dienes has been successfully achieved. Sequential regioselective C-C bond and enantioselective C-N formation allows rapid assembly wide range value-added chiral allylic amines from readily available

Language: Английский

Citations

3
Enantioselective Synthesis of Aminals Via Nickel-Catalyzed Hydroamination of 2-Azadienes with Indoles and N-Heterocycles DOI
Ya Du,

Shengzu Duan,

Shuntao Huang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(45), P. 30947 - 30957

Published: Oct. 30, 2024

New methods for the enantioselective synthesis of N-alkylated indoles and their derivatives are great interest because pivotal structural elements in biologically active molecules natural products. They also versatile intermediates organic synthesis. Among well-established asymmetric hydroamination methods, with indole-based substrates is a formidable challenge. This observation likely due to reduced nucleophilicity indole nitrogen. Herein, unique nickel-catalyzed enantio- branched-selective 2-azadienes structurally related N-heterocycles reported generation enantioenriched

Language: Английский

Citations

0