Layered Double Hydroxide (LDH)-Based Nanotripod for High-Entropydynamic Therapy Associated with Metabolism Homeostasis DOI
Kai Song, Xueting Yang, Yingying Ren

et al.

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Multielemental transition metal compounds represent a class of promising candidates for the biomedical field due to their unique structure and application potential. However, synthesis process remains challenging, which was subject high-temperature treatment multimetallic elements integrated within one system. Herein, first time, we have fabricated nanotripod,

Language: Английский

New horizons for the therapeutic application of nanozymes in cancer treatment DOI Creative Commons
Pravanjan Malla, Yu‐Ming Wang, Chia‐Hao Su

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Language: Английский

Citations

3
Biomimetic NIR-II Aggregation-Induced Emission Nanoparticles for Targeted Photothermal Therapy of Ovarian Cancer DOI
Ting Jiang, Chunlei Guo, Zhiwei Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Photothermal therapy (PTT) is a cutting-edge technique that harnesses light energy and converts it into heat for precise tumor ablation. By employing photothermal agents to selectively generate target cancer cells, PTT has emerged as promising treatment strategy. Notably, therapies conducted in the second near-infrared (NIR-II) window exhibit superior therapeutic outcomes, owing deeper tissue penetration reduced scattering. In this study, we developed biomimetic NIR-II aggregation-induced emission (AIE) nanoparticles (2TB-NPs@TM) high-efficiency imaging targeted phototherapy of ovarian cancer. The core nanoparticle aggregates (2TB-NPs) display strong fluorescence high conversion efficiency, while outer cell membrane coating facilitates active targeting recognition tissues. This design imparts excellent biocompatibility enhances drug delivery leading potent synergistic effects. Our findings open new avenues advancing targeted, high-performance diagnostics treatment.

Language: Английский

Citations

1
Indacenodithienothiophene-based A-D-A-type phototheranostics for immuno-phototherapy DOI Creative Commons

Yangtian Ye,

Shaojing Zhao,

E Pang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract The development of phototherapeutics with high photothermal conversion efficiency (PCE) and strong ability to generate reactive oxygen species under single near-infrared (NIR) laser irradiation for immuno-phototherapy applications remains a significant challenge. Herein, we optimally selected the molecule IT-4F an acceptor-donor-acceptor (A-D-A) structure prepare water-dispersible nanoparticles (NPs) by assembly DSPE-PEG-NH2. Such NPs have NIR absorption fluorescence peaks at 728 817 nm, respectively. They can singlet (1O2) superoxide anion (O2-·) irradiation, 1O2 generation quantum yield 31.5%. also effectively convert photon-energy into heat PCE 42.8%. outstanding properties enable them be used in imaging guided therapy (PTT), photodynamic (PDT). Moreover, PDT PTT triggered immunogenic cell death PANoptosis tumor cells, which not only inhibited growth metastasis mice model, but induced robust immune response, evidenced increased infiltration CD8+ T CD4+ dendritic decreased presence immunosuppressive cells such as myeloid-derived suppressor regulatory cells. efficacy organoid human breast cancer was verified.

Language: Английский

Citations

0
High Entropy Layered Double Hydroxide Nanozyme for Sensitive Detection of Tetracycline DOI

Lupeng Dou,

Ke Xiao

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: 8(5), P. 2456 - 2465

Published: Jan. 29, 2025

Monitoring and controlling antibiotic residues in the environment are critical for minimizing bacterial resistance, preserving microecological equilibrium, protecting human health. Core competencies of sensor include sensitivity, selectivity, mobility. It is still very difficult to combine these qualities a single effective tetracycline (TC) detection. Herein, flower-like spherical structure high-entropy layered double hydroxide Fe0.45Co0.45Ni0.45Cu0.45Zn0.45-LDH (HE-LDH) was prepared with superior peroxide-like activity convert hydrogen peroxide (H2O2) hydroxyl radicals (•OH) (Km = 0.075 mM H2O2). Because significant reactivity that exists between TC •OH produced catalytic system, simple colorimetric method detection established. As performance, linear range limit were 100–1000 25.6 nM solution mode, respectively. Also, 100–800 32.2 obtained paper mode. The developed also exhibited good selectivity over other antibiotics, amino acids, ions. Furthermore, use actual water sample analysis demonstrated excellent self-calibration satisfactory recovery 95.4–103.1%. This study offers progress toward developing nanozymes enzyme-like detection, accelerating development efficient portable sensors.

Language: Английский

Citations

0
FeCuS multilayer nanoflowers loaded with N-CDs dual-mode method for the detection of uric acid and gout risk prediction with the aid of chemometrics DOI

Rou Cheng,

Chunyan Yan, Zhenggang Xiao

et al.

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127700 - 127700

Published: Feb. 5, 2025

Language: Английский

Citations

0
A Self-Immobilizing Photoacoustic Probe for Ratiometric In Vivo Imaging of Cu(II) in Tumors DOI Creative Commons
Qian Sun, Huan Liu, Ying Yang

et al.

Chemical & Biomedical Imaging, Journal Year: 2025, Volume and Issue: 3(4), P. 260 - 266

Published: March 3, 2025

Cu(II) ions play a critical role in tumor growth and metastasis, making vivo high-resolution imaging of crucial for understanding its pathophysiology. However, designing suitable molecular probes this purpose remains challenging. Herein, we report the development photoacoustic probe specific tumors. This utilizes β-galactoside as targeting group incorporates unique self-immobilization strategy. Upon β-galactosidase-mediated cleavage, generates reactive quinone methide intermediate that covalently binds to intracellular proteins, enabling selective accumulation. The exhibits ratiometric response with high selectivity over other biological species. In vitro studies demonstrated efficacy research provides valuable insights into tumorigenesis may facilitate diagnostic therapeutic approaches cancer.

Language: Английский

Citations

0
Combinatorial Neoadjuvant and Photoinduced Adoptive Cellular Immunotherapy via MXene Nanosphere DOI

Ammavasi Chandran Ambigaibalan,

Sivaraj Mehnath,

Priya Dharshini Krishnan

et al.

ACS Applied Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Defect-Engineered CoFe Layered Double Hydroxide Quantum Dots: Oxygen Vacancy-Driven Boost in Peroxidase-Mimic Catalysis for Multiplex Biomarker Sensing DOI
Zhongwei Yang, Xiaoyu Zhang, Longwei Wang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1777 - 1785

Published: April 8, 2025

Language: Английский

Citations

0
Top-down bioinspired nanotheranostics with AIE luminogens DOI
Xiaoyu Xu,

Luojia Chen,

Yang Liu

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 537, P. 216681 - 216681

Published: April 15, 2025

Language: Английский

Citations

0
Portable colorimetric probe based on high-entropy alloy nanozyme for rapid detection of fruit freshness DOI
Yufeng Liu, J.P. Zhang, Wei Xia

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 483, P. 144345 - 144345

Published: April 14, 2025

Language: Английский

Citations

0